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Maternal food consumption during pregnancy and the longitudinal development of childhood asthma.
Am J Respir Crit Care Med 2008; 178(2):124-31AJ

Abstract

RATIONALE

Maternal diet during pregnancy has the potential to affect airway development and to promote T-helper-2-cell responses during fetal life. This might increase the risk of developing childhood asthma or allergy.

OBJECTIVES

We investigated the influence of maternal food consumption during pregnancy on childhood asthma outcomes from 1 to 8 years of age.

METHODS

A birth cohort study consisting of a baseline of 4,146 pregnant women (1,327 atopic and 2,819 nonatopic). These women were asked about their frequency of consumption of fruit, vegetables, fish, egg, milk, milk products, nuts, and nut products during the last month. Their children were followed until 8 years of age. Longitudinal analyses were conducted to assess associations between maternal diet during pregnancy and childhood asthma outcomes over 8 years.

MEASUREMENTS AND MAIN RESULTS

Complete data were obtained for 2,832 children. There were no associations between maternal vegetable, fish, egg, milk or milk products, and nut consumption and longitudinal childhood outcomes. Daily consumption of nut products increased the risk of childhood wheeze (odds ratio [OR] daily versus rare consumption, 1.42; 95% confidence interval [95% CI], 1.06-1.89), dyspnea (OR, 1.58; 95% CI, 1.16-2.15), steroid use (OR, 1.62; 95% CI, 1.06-2.46), and asthma symptoms (OR, 1.47; 95% CI, 1.08-1.99).

CONCLUSIONS

Results of this study indicate an increased risk of daily versus rare consumption of nut products during pregnancy on childhood asthma outcomes. These findings need to be replicated by other studies before dietary advice can be given to pregnant women.

Authors+Show Affiliations

Institute for Risk Assessment Sciences, Division of Environmental Epidemiology, Utrecht University, P.O. Box 80178, 3508 TD Utrecht, The Netherlands. s.m.willers@uu.nlNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18403722

Citation

Willers, Saskia M., et al. "Maternal Food Consumption During Pregnancy and the Longitudinal Development of Childhood Asthma." American Journal of Respiratory and Critical Care Medicine, vol. 178, no. 2, 2008, pp. 124-31.
Willers SM, Wijga AH, Brunekreef B, et al. Maternal food consumption during pregnancy and the longitudinal development of childhood asthma. Am J Respir Crit Care Med. 2008;178(2):124-31.
Willers, S. M., Wijga, A. H., Brunekreef, B., Kerkhof, M., Gerritsen, J., Hoekstra, M. O., ... Smit, H. A. (2008). Maternal food consumption during pregnancy and the longitudinal development of childhood asthma. American Journal of Respiratory and Critical Care Medicine, 178(2), pp. 124-31. doi:10.1164/rccm.200710-1544OC.
Willers SM, et al. Maternal Food Consumption During Pregnancy and the Longitudinal Development of Childhood Asthma. Am J Respir Crit Care Med. 2008 Jul 15;178(2):124-31. PubMed PMID: 18403722.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Maternal food consumption during pregnancy and the longitudinal development of childhood asthma. AU - Willers,Saskia M, AU - Wijga,Alet H, AU - Brunekreef,Bert, AU - Kerkhof,Marjan, AU - Gerritsen,Jorrit, AU - Hoekstra,Maarten O, AU - de Jongste,Johan C, AU - Smit,Henriette A, Y1 - 2008/04/10/ PY - 2008/4/12/pubmed PY - 2008/8/14/medline PY - 2008/4/12/entrez SP - 124 EP - 31 JF - American journal of respiratory and critical care medicine JO - Am. J. Respir. Crit. Care Med. VL - 178 IS - 2 N2 - RATIONALE: Maternal diet during pregnancy has the potential to affect airway development and to promote T-helper-2-cell responses during fetal life. This might increase the risk of developing childhood asthma or allergy. OBJECTIVES: We investigated the influence of maternal food consumption during pregnancy on childhood asthma outcomes from 1 to 8 years of age. METHODS: A birth cohort study consisting of a baseline of 4,146 pregnant women (1,327 atopic and 2,819 nonatopic). These women were asked about their frequency of consumption of fruit, vegetables, fish, egg, milk, milk products, nuts, and nut products during the last month. Their children were followed until 8 years of age. Longitudinal analyses were conducted to assess associations between maternal diet during pregnancy and childhood asthma outcomes over 8 years. MEASUREMENTS AND MAIN RESULTS: Complete data were obtained for 2,832 children. There were no associations between maternal vegetable, fish, egg, milk or milk products, and nut consumption and longitudinal childhood outcomes. Daily consumption of nut products increased the risk of childhood wheeze (odds ratio [OR] daily versus rare consumption, 1.42; 95% confidence interval [95% CI], 1.06-1.89), dyspnea (OR, 1.58; 95% CI, 1.16-2.15), steroid use (OR, 1.62; 95% CI, 1.06-2.46), and asthma symptoms (OR, 1.47; 95% CI, 1.08-1.99). CONCLUSIONS: Results of this study indicate an increased risk of daily versus rare consumption of nut products during pregnancy on childhood asthma outcomes. These findings need to be replicated by other studies before dietary advice can be given to pregnant women. SN - 1535-4970 UR - https://www.unboundmedicine.com/medline/citation/18403722/Maternal_food_consumption_during_pregnancy_and_the_longitudinal_development_of_childhood_asthma_ L2 - http://www.atsjournals.org/doi/full/10.1164/rccm.200710-1544OC?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -