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High-sensitivity C-reactive protein and coronary heart disease in a general population of Japanese: the Hisayama study.
Arterioscler Thromb Vasc Biol. 2008 Jul; 28(7):1385-91.AT

Abstract

OBJECTIVE

The purpose of this study was to investigate the effects of high-sensitivity C-reactive protein (hs-CRP) on the risks of coronary heart disease (CHD) in a general population of Japanese.

METHODS AND RESULTS

The Hisayama study is a population-based prospective cohort study. A total of 2589 participants aged 40 years or older were followed up for 14 years. Outcomes are incident CHD (myocardial infarction, coronary revascularization, and sudden cardiac death). The median hs-CRP level was 0.43 mg/L at baseline. During the follow-up period, 129 coronary events were observed. Age- and sex-adjusted annual incidence rates of CHD rose progressively with higher hs-CRP levels: 1.6, 3.3, 4.5, and 7.4 per 1000 person-years for quartile groups defined by hs-CRP levels of <0.21, 0.21 to 0.43, 0.44 to 1.02, and >1.02 mg/L, respectively (P<0.0001 for trend). The risk of CHD in the highest quartile group was 2.98-fold (95% CI, 1.53 to 5.82) higher than that in the lowest group even after controlling for other cardiovascular risk factors.

CONCLUSIONS

hs-CRP levels were clearly associated with future CHD events in a general population of Japanese. In Japanese populations, the hs-CRP cut-off point for high-risk of future development of CHD is likely to be >1.0 mg/L, which is much lower than that for Western populations.

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Authors+Show Affiliations

Arima H
Department of Environmental Medicine, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan. harima@envmed.med.kyushu-u.ac.jp
Kubo M
No affiliation info available
Yonemoto K
No affiliation info available
Doi Y
No affiliation info available
Ninomiya T
No affiliation info available
Tanizaki Y
No affiliation info available
Hata J
No affiliation info available
Matsumura K
No affiliation info available
Iida M
No affiliation info available
Kiyohara Y
No affiliation info available

MeSH

AdultAgedAsian Continental Ancestry GroupBiomarkersC-Reactive ProteinCoronary DiseaseFemaleFollow-Up StudiesHumansIncidenceInflammationJapanMaleMiddle AgedOdds RatioPopulation SurveillanceProspective StudiesRisk AssessmentRisk FactorsTime FactorsUp-Regulation

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18403728

Citation

Arima, Hisatomi, et al. "High-sensitivity C-reactive Protein and Coronary Heart Disease in a General Population of Japanese: the Hisayama Study." Arteriosclerosis, Thrombosis, and Vascular Biology, vol. 28, no. 7, 2008, pp. 1385-91.
Arima H, Kubo M, Yonemoto K, et al. High-sensitivity C-reactive protein and coronary heart disease in a general population of Japanese: the Hisayama study. Arterioscler Thromb Vasc Biol. 2008;28(7):1385-91.
Arima, H., Kubo, M., Yonemoto, K., Doi, Y., Ninomiya, T., Tanizaki, Y., Hata, J., Matsumura, K., Iida, M., & Kiyohara, Y. (2008). High-sensitivity C-reactive protein and coronary heart disease in a general population of Japanese: the Hisayama study. Arteriosclerosis, Thrombosis, and Vascular Biology, 28(7), 1385-91. https://doi.org/10.1161/ATVBAHA.107.157164
Arima H, et al. High-sensitivity C-reactive Protein and Coronary Heart Disease in a General Population of Japanese: the Hisayama Study. Arterioscler Thromb Vasc Biol. 2008;28(7):1385-91. PubMed PMID: 18403728.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - High-sensitivity C-reactive protein and coronary heart disease in a general population of Japanese: the Hisayama study. AU - Arima,Hisatomi, AU - Kubo,Michiaki, AU - Yonemoto,Koji, AU - Doi,Yasufumi, AU - Ninomiya,Toshiharu, AU - Tanizaki,Yumihiro, AU - Hata,Jun, AU - Matsumura,Kiyoshi, AU - Iida,Mitsuo, AU - Kiyohara,Yutaka, Y1 - 2008/04/10/ PY - 2008/4/12/pubmed PY - 2008/7/4/medline PY - 2008/4/12/entrez SP - 1385 EP - 91 JF - Arteriosclerosis, thrombosis, and vascular biology JO - Arterioscler Thromb Vasc Biol VL - 28 IS - 7 N2 - OBJECTIVE: The purpose of this study was to investigate the effects of high-sensitivity C-reactive protein (hs-CRP) on the risks of coronary heart disease (CHD) in a general population of Japanese. METHODS AND RESULTS: The Hisayama study is a population-based prospective cohort study. A total of 2589 participants aged 40 years or older were followed up for 14 years. Outcomes are incident CHD (myocardial infarction, coronary revascularization, and sudden cardiac death). The median hs-CRP level was 0.43 mg/L at baseline. During the follow-up period, 129 coronary events were observed. Age- and sex-adjusted annual incidence rates of CHD rose progressively with higher hs-CRP levels: 1.6, 3.3, 4.5, and 7.4 per 1000 person-years for quartile groups defined by hs-CRP levels of <0.21, 0.21 to 0.43, 0.44 to 1.02, and >1.02 mg/L, respectively (P<0.0001 for trend). The risk of CHD in the highest quartile group was 2.98-fold (95% CI, 1.53 to 5.82) higher than that in the lowest group even after controlling for other cardiovascular risk factors. CONCLUSIONS: hs-CRP levels were clearly associated with future CHD events in a general population of Japanese. In Japanese populations, the hs-CRP cut-off point for high-risk of future development of CHD is likely to be >1.0 mg/L, which is much lower than that for Western populations. SN - 1524-4636 UR - https://www.unboundmedicine.com/medline/citation/18403728/High_sensitivity_C_reactive_protein_and_coronary_heart_disease_in_a_general_population_of_Japanese:_the_Hisayama_study_ L2 - https://www.ahajournals.org/doi/10.1161/ATVBAHA.107.157164?url_ver=Z39.88-2003&amp;rfr_id=ori:rid:crossref.org&amp;rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -
Grapherence [↓41]

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