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High-sensitivity C-reactive protein and coronary heart disease in a general population of Japanese: the Hisayama study.
Arterioscler Thromb Vasc Biol. 2008 Jul; 28(7):1385-91.AT

Abstract

OBJECTIVE

The purpose of this study was to investigate the effects of high-sensitivity C-reactive protein (hs-CRP) on the risks of coronary heart disease (CHD) in a general population of Japanese.

METHODS AND RESULTS

The Hisayama study is a population-based prospective cohort study. A total of 2589 participants aged 40 years or older were followed up for 14 years. Outcomes are incident CHD (myocardial infarction, coronary revascularization, and sudden cardiac death). The median hs-CRP level was 0.43 mg/L at baseline. During the follow-up period, 129 coronary events were observed. Age- and sex-adjusted annual incidence rates of CHD rose progressively with higher hs-CRP levels: 1.6, 3.3, 4.5, and 7.4 per 1000 person-years for quartile groups defined by hs-CRP levels of <0.21, 0.21 to 0.43, 0.44 to 1.02, and >1.02 mg/L, respectively (P<0.0001 for trend). The risk of CHD in the highest quartile group was 2.98-fold (95% CI, 1.53 to 5.82) higher than that in the lowest group even after controlling for other cardiovascular risk factors.

CONCLUSIONS

hs-CRP levels were clearly associated with future CHD events in a general population of Japanese. In Japanese populations, the hs-CRP cut-off point for high-risk of future development of CHD is likely to be >1.0 mg/L, which is much lower than that for Western populations.

Authors+Show Affiliations

Department of Environmental Medicine, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan. harima@envmed.med.kyushu-u.ac.jpNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18403728

Citation

Arima, Hisatomi, et al. "High-sensitivity C-reactive Protein and Coronary Heart Disease in a General Population of Japanese: the Hisayama Study." Arteriosclerosis, Thrombosis, and Vascular Biology, vol. 28, no. 7, 2008, pp. 1385-91.
Arima H, Kubo M, Yonemoto K, et al. High-sensitivity C-reactive protein and coronary heart disease in a general population of Japanese: the Hisayama study. Arterioscler Thromb Vasc Biol. 2008;28(7):1385-91.
Arima, H., Kubo, M., Yonemoto, K., Doi, Y., Ninomiya, T., Tanizaki, Y., Hata, J., Matsumura, K., Iida, M., & Kiyohara, Y. (2008). High-sensitivity C-reactive protein and coronary heart disease in a general population of Japanese: the Hisayama study. Arteriosclerosis, Thrombosis, and Vascular Biology, 28(7), 1385-91. https://doi.org/10.1161/ATVBAHA.107.157164
Arima H, et al. High-sensitivity C-reactive Protein and Coronary Heart Disease in a General Population of Japanese: the Hisayama Study. Arterioscler Thromb Vasc Biol. 2008;28(7):1385-91. PubMed PMID: 18403728.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - High-sensitivity C-reactive protein and coronary heart disease in a general population of Japanese: the Hisayama study. AU - Arima,Hisatomi, AU - Kubo,Michiaki, AU - Yonemoto,Koji, AU - Doi,Yasufumi, AU - Ninomiya,Toshiharu, AU - Tanizaki,Yumihiro, AU - Hata,Jun, AU - Matsumura,Kiyoshi, AU - Iida,Mitsuo, AU - Kiyohara,Yutaka, Y1 - 2008/04/10/ PY - 2008/4/12/pubmed PY - 2008/7/4/medline PY - 2008/4/12/entrez SP - 1385 EP - 91 JF - Arteriosclerosis, thrombosis, and vascular biology JO - Arterioscler Thromb Vasc Biol VL - 28 IS - 7 N2 - OBJECTIVE: The purpose of this study was to investigate the effects of high-sensitivity C-reactive protein (hs-CRP) on the risks of coronary heart disease (CHD) in a general population of Japanese. METHODS AND RESULTS: The Hisayama study is a population-based prospective cohort study. A total of 2589 participants aged 40 years or older were followed up for 14 years. Outcomes are incident CHD (myocardial infarction, coronary revascularization, and sudden cardiac death). The median hs-CRP level was 0.43 mg/L at baseline. During the follow-up period, 129 coronary events were observed. Age- and sex-adjusted annual incidence rates of CHD rose progressively with higher hs-CRP levels: 1.6, 3.3, 4.5, and 7.4 per 1000 person-years for quartile groups defined by hs-CRP levels of <0.21, 0.21 to 0.43, 0.44 to 1.02, and >1.02 mg/L, respectively (P<0.0001 for trend). The risk of CHD in the highest quartile group was 2.98-fold (95% CI, 1.53 to 5.82) higher than that in the lowest group even after controlling for other cardiovascular risk factors. CONCLUSIONS: hs-CRP levels were clearly associated with future CHD events in a general population of Japanese. In Japanese populations, the hs-CRP cut-off point for high-risk of future development of CHD is likely to be >1.0 mg/L, which is much lower than that for Western populations. SN - 1524-4636 UR - https://www.unboundmedicine.com/medline/citation/18403728/High_sensitivity_C_reactive_protein_and_coronary_heart_disease_in_a_general_population_of_Japanese:_the_Hisayama_study_ L2 - https://www.ahajournals.org/doi/10.1161/ATVBAHA.107.157164?url_ver=Z39.88-2003&amp;rfr_id=ori:rid:crossref.org&amp;rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -