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The role of nutrition in hepatic encephalopathy.

Abstract

PURPOSE OF REVIEW

Protein-calorie malnutrition may be observed in all clinical stages of liver disease. Nutritional management in these patients is imperative. It is crucial that protein intake is not restricted ad hoc. Administration of vegetable proteins for patients who cannot tolerate standard proteins and, if necessary, branched-chain amino acid-enriched formulae can be an option to these patients. This issue, however, remains controversial.

RECENT FINDINGS

This study is an update on the nutritional management of hepatic encephalopathy based on several studies of the last decades, involving dietary protein intake and branched-chain amino acid supplementation.

SUMMARY

Malnutrition is a common complication of liver disease and it adversely affects patient outcome. Inadequate dietary protein intake has a very deleterious effect on hepatic encephalopathy, nutritional status, and clinical outcome in these patients and must be avoided. The administration of branched-chain amino acids stimulates hepatic protein synthesis, reduces postinjury catabolism and therefore improves nutritional status. Conflicting results in various different trials, however, exist, and this issue remains unclear.

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  • Publisher Full Text
  • Authors+Show Affiliations

    ,

    Department of Digestive Surgery, Federal University of Parana, Curitiba, Parana, Brazil. gjschulz@hotmail.com

    ,

    Source

    MeSH

    Amino Acids, Branched-Chain
    Dietary Proteins
    Dietary Supplements
    Hepatic Encephalopathy
    Humans
    Nutritional Status
    Nutritional Support
    Protein-Energy Malnutrition
    Treatment Outcome

    Pub Type(s)

    Journal Article
    Review

    Language

    eng

    PubMed ID

    18403924

    Citation

    Schulz, Gustavo Justo, et al. "The Role of Nutrition in Hepatic Encephalopathy." Current Opinion in Clinical Nutrition and Metabolic Care, vol. 11, no. 3, 2008, pp. 275-80.
    Schulz GJ, Campos AC, Coelho JC. The role of nutrition in hepatic encephalopathy. Curr Opin Clin Nutr Metab Care. 2008;11(3):275-80.
    Schulz, G. J., Campos, A. C., & Coelho, J. C. (2008). The role of nutrition in hepatic encephalopathy. Current Opinion in Clinical Nutrition and Metabolic Care, 11(3), pp. 275-80. doi:10.1097/MCO.0b013e3282f9e870.
    Schulz GJ, Campos AC, Coelho JC. The Role of Nutrition in Hepatic Encephalopathy. Curr Opin Clin Nutr Metab Care. 2008;11(3):275-80. PubMed PMID: 18403924.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - The role of nutrition in hepatic encephalopathy. AU - Schulz,Gustavo Justo, AU - Campos,Antônio Carlos Ligocki, AU - Coelho,Julio Cezar Uili, PY - 2008/4/12/pubmed PY - 2008/9/10/medline PY - 2008/4/12/entrez SP - 275 EP - 80 JF - Current opinion in clinical nutrition and metabolic care JO - Curr Opin Clin Nutr Metab Care VL - 11 IS - 3 N2 - PURPOSE OF REVIEW: Protein-calorie malnutrition may be observed in all clinical stages of liver disease. Nutritional management in these patients is imperative. It is crucial that protein intake is not restricted ad hoc. Administration of vegetable proteins for patients who cannot tolerate standard proteins and, if necessary, branched-chain amino acid-enriched formulae can be an option to these patients. This issue, however, remains controversial. RECENT FINDINGS: This study is an update on the nutritional management of hepatic encephalopathy based on several studies of the last decades, involving dietary protein intake and branched-chain amino acid supplementation. SUMMARY: Malnutrition is a common complication of liver disease and it adversely affects patient outcome. Inadequate dietary protein intake has a very deleterious effect on hepatic encephalopathy, nutritional status, and clinical outcome in these patients and must be avoided. The administration of branched-chain amino acids stimulates hepatic protein synthesis, reduces postinjury catabolism and therefore improves nutritional status. Conflicting results in various different trials, however, exist, and this issue remains unclear. SN - 1363-1950 UR - https://www.unboundmedicine.com/medline/citation/18403924/The_role_of_nutrition_in_hepatic_encephalopathy_ L2 - http://Insights.ovid.com/pubmed?pmid=18403924 DB - PRIME DP - Unbound Medicine ER -