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Issues related to gluten-free diet in coeliac disease.
Curr Opin Clin Nutr Metab Care 2008; 11(3):329-33CO

Abstract

PURPOSE OF REVIEW

In the last few years, knowledge about coeliac disease has significantly improved, resulting in a better understanding of disease pathogenesis, diagnosis and therapy. This review describes the latest progress in research concerning treatment with gluten-free diet in patients with coeliac disease.

RECENT FINDINGS

Gluten-free diet is generally admitted as effective therapy in symptomatic patients, but a life-long dietary treatment in some challenging cases such as 'silent' and 'latent' patients is under discussion. Tolerance to gluten may be acquired later in life, but, as latency may be transient, a strict follow-up is necessary in these patients. The composition of gluten-free diet needs a better definition; latest evidence demonstrates that oats are tolerated by most patients with coeliac disease. Finally, the amount of gluten permitted in gluten-free products is still a matter of debate; significant progress has been made in the sensitivity of techniques for gluten detection, but the daily amount of gluten that can be safely consumed is not yet defined.

SUMMARY

Gluten-free diet remains the cornerstone of therapy of coeliac disease. More studies addressing the need of gluten-free diet for cases of 'potential' coeliac disease are necessary, as well as studies linking the best available analytical detection of gluten to the clinical threshold of tolerance.

Authors+Show Affiliations

Department of Pediatrics and European Laboratory for the Investigation of Food-Induced Diseases, University Federico II, Naples, Italy. troncone@unina.itNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

18403932

Citation

Troncone, Riccardo, et al. "Issues Related to Gluten-free Diet in Coeliac Disease." Current Opinion in Clinical Nutrition and Metabolic Care, vol. 11, no. 3, 2008, pp. 329-33.
Troncone R, Auricchio R, Granata V. Issues related to gluten-free diet in coeliac disease. Curr Opin Clin Nutr Metab Care. 2008;11(3):329-33.
Troncone, R., Auricchio, R., & Granata, V. (2008). Issues related to gluten-free diet in coeliac disease. Current Opinion in Clinical Nutrition and Metabolic Care, 11(3), pp. 329-33. doi:10.1097/MCO.0b013e3282f795f8.
Troncone R, Auricchio R, Granata V. Issues Related to Gluten-free Diet in Coeliac Disease. Curr Opin Clin Nutr Metab Care. 2008;11(3):329-33. PubMed PMID: 18403932.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Issues related to gluten-free diet in coeliac disease. AU - Troncone,Riccardo, AU - Auricchio,Renata, AU - Granata,Viviana, PY - 2008/4/12/pubmed PY - 2008/9/10/medline PY - 2008/4/12/entrez SP - 329 EP - 33 JF - Current opinion in clinical nutrition and metabolic care JO - Curr Opin Clin Nutr Metab Care VL - 11 IS - 3 N2 - PURPOSE OF REVIEW: In the last few years, knowledge about coeliac disease has significantly improved, resulting in a better understanding of disease pathogenesis, diagnosis and therapy. This review describes the latest progress in research concerning treatment with gluten-free diet in patients with coeliac disease. RECENT FINDINGS: Gluten-free diet is generally admitted as effective therapy in symptomatic patients, but a life-long dietary treatment in some challenging cases such as 'silent' and 'latent' patients is under discussion. Tolerance to gluten may be acquired later in life, but, as latency may be transient, a strict follow-up is necessary in these patients. The composition of gluten-free diet needs a better definition; latest evidence demonstrates that oats are tolerated by most patients with coeliac disease. Finally, the amount of gluten permitted in gluten-free products is still a matter of debate; significant progress has been made in the sensitivity of techniques for gluten detection, but the daily amount of gluten that can be safely consumed is not yet defined. SUMMARY: Gluten-free diet remains the cornerstone of therapy of coeliac disease. More studies addressing the need of gluten-free diet for cases of 'potential' coeliac disease are necessary, as well as studies linking the best available analytical detection of gluten to the clinical threshold of tolerance. SN - 1363-1950 UR - https://www.unboundmedicine.com/medline/citation/18403932/Issues_related_to_gluten_free_diet_in_coeliac_disease_ L2 - http://Insights.ovid.com/pubmed?pmid=18403932 DB - PRIME DP - Unbound Medicine ER -