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Risk factors associated with nonalcoholic fatty liver disease and its relationship with the hepatic histological changes.
Eur J Gastroenterol Hepatol 2008; 20(5):399-403EJ

Abstract

OBJECTIVE

The objective of this study is to determine the association between risk factors and nonalcoholic fatty liver disease (NAFLD), and to establish the relationship between risk factors and hepatic histological changes in obese women.

METHODS

A case-control design study. Women with NAFLD (cases) were compared with a control group of obese women without NAFLD matched by age, body mass index, waist circumference, and body fat. Irrespective of serum aminotransferases levels, diagnosis of NAFLD was established by the presence of type II diabetes, hypertriglyceridemia, and ultrasonographic changes of hepatic steatosis. Diagnosis of nonalcoholic steatohepatitis was performed by a liver biopsy. Women with an aspartate aminotransferase/alanine aminotransferase (ALT) ratio of at least 1 underwent liver biopsy. Alcohol consumption, hepatitis, and drugs that promote cholestasis or liver injury were the exclusion criteria. Multiple regression analysis was used to compute the association between the risk factors and NAFLD, and Spearman's analysis was used to examine its relationship with histological hepatic changes.

RESULTS

A total of 108 obese women were enrolled. The frequency of high blood pressure, hypertriglyceridemia, and diabetes was similar between the groups. ALT (54.4+/-33.3 and 39.8+/-29.8, P=0.03) but not aspartate aminotransferase (45.4+/-23.1 and 36.7+/-21.2, P=0.06) was significantly higher in the women with NAFLD. The multivariate regression analysis showed a significant association of ALT (odds ratio 2.7; 95% confidence interval, 1.3-10.4), but not other variables with NAFLD. Type II diabetes was strongly correlated with ballooning and inflammation, and ALT with inflammation and fibrosis.

CONCLUSION

Obese women with similar metabolic alterations exhibit different hepatic outcomes. Elevation of ALT, but not other risk factors, was associated with NAFLD. Diabetes and ALT correlate with histological hepatic changes.

Authors+Show Affiliations

Biomedical Research Unit, Mexican Social Security Institute, General Hospital of the Mexican Social Security Institute, Durango, Mexico.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18403941

Citation

Rodríguez-Hernández, Heriberto, et al. "Risk Factors Associated With Nonalcoholic Fatty Liver Disease and Its Relationship With the Hepatic Histological Changes." European Journal of Gastroenterology & Hepatology, vol. 20, no. 5, 2008, pp. 399-403.
Rodríguez-Hernández H, Gonzalez JL, Márquez-Ramirez MD, et al. Risk factors associated with nonalcoholic fatty liver disease and its relationship with the hepatic histological changes. Eur J Gastroenterol Hepatol. 2008;20(5):399-403.
Rodríguez-Hernández, H., Gonzalez, J. L., Márquez-Ramirez, M. D., Flores-Hernandez, M., Rodríguez-Morán, M., & Guerrero-Romero, F. (2008). Risk factors associated with nonalcoholic fatty liver disease and its relationship with the hepatic histological changes. European Journal of Gastroenterology & Hepatology, 20(5), pp. 399-403. doi:10.1097/MEG.0b013e3282f448af.
Rodríguez-Hernández H, et al. Risk Factors Associated With Nonalcoholic Fatty Liver Disease and Its Relationship With the Hepatic Histological Changes. Eur J Gastroenterol Hepatol. 2008;20(5):399-403. PubMed PMID: 18403941.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Risk factors associated with nonalcoholic fatty liver disease and its relationship with the hepatic histological changes. AU - Rodríguez-Hernández,Heriberto, AU - Gonzalez,José L, AU - Márquez-Ramirez,Maria Dolores, AU - Flores-Hernandez,Marissa, AU - Rodríguez-Morán,Martha, AU - Guerrero-Romero,Fernando, PY - 2008/4/12/pubmed PY - 2008/8/22/medline PY - 2008/4/12/entrez SP - 399 EP - 403 JF - European journal of gastroenterology & hepatology JO - Eur J Gastroenterol Hepatol VL - 20 IS - 5 N2 - OBJECTIVE: The objective of this study is to determine the association between risk factors and nonalcoholic fatty liver disease (NAFLD), and to establish the relationship between risk factors and hepatic histological changes in obese women. METHODS: A case-control design study. Women with NAFLD (cases) were compared with a control group of obese women without NAFLD matched by age, body mass index, waist circumference, and body fat. Irrespective of serum aminotransferases levels, diagnosis of NAFLD was established by the presence of type II diabetes, hypertriglyceridemia, and ultrasonographic changes of hepatic steatosis. Diagnosis of nonalcoholic steatohepatitis was performed by a liver biopsy. Women with an aspartate aminotransferase/alanine aminotransferase (ALT) ratio of at least 1 underwent liver biopsy. Alcohol consumption, hepatitis, and drugs that promote cholestasis or liver injury were the exclusion criteria. Multiple regression analysis was used to compute the association between the risk factors and NAFLD, and Spearman's analysis was used to examine its relationship with histological hepatic changes. RESULTS: A total of 108 obese women were enrolled. The frequency of high blood pressure, hypertriglyceridemia, and diabetes was similar between the groups. ALT (54.4+/-33.3 and 39.8+/-29.8, P=0.03) but not aspartate aminotransferase (45.4+/-23.1 and 36.7+/-21.2, P=0.06) was significantly higher in the women with NAFLD. The multivariate regression analysis showed a significant association of ALT (odds ratio 2.7; 95% confidence interval, 1.3-10.4), but not other variables with NAFLD. Type II diabetes was strongly correlated with ballooning and inflammation, and ALT with inflammation and fibrosis. CONCLUSION: Obese women with similar metabolic alterations exhibit different hepatic outcomes. Elevation of ALT, but not other risk factors, was associated with NAFLD. Diabetes and ALT correlate with histological hepatic changes. SN - 0954-691X UR - https://www.unboundmedicine.com/medline/citation/18403941/Risk_factors_associated_with_nonalcoholic_fatty_liver_disease_and_its_relationship_with_the_hepatic_histological_changes_ L2 - http://Insights.ovid.com/pubmed?pmid=18403941 DB - PRIME DP - Unbound Medicine ER -