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Antinociceptive, anti-inflammatory, and antipyretic properties of an aqueous extract of Dicranopteris linearis leaves in experimental animal models.
J Nat Med. 2008 Apr; 62(2):179-87.JN

Abstract

This study was performed out to establish the antinociceptive, anti-inflammatory, and antipyretic properties of an aqueous extract of Dicranopteris linearis leaves in experimental animals. The antinociceptive activity was measured using the abdominal constriction, hot plate, and formalin tests. The anti-inflammatory and antipyretic activities were measured using the carrageenan-induced paw edema and brewer's yeast-induced pyrexia tests, respectively. The extract, obtained after 72 h soaking of the air-dried leaves in distilled water and then prepared in the doses of 13.2, 66.0, 132.0, and 660.0 mg/kg, was administered subcutaneously 30 min before subjecting the animals to the assays mentioned above. Generally, the extract, at all doses used, was found to have significant (P < 0.05) concentration-independent antinociceptive, anti-inflammatory, and anti-pyretic activity. In conclusion, the aqueous extract of D. linearis has antinociceptive, anti-inflammatory, and antipyretic activity, supporting previous claims of its traditional use by the Malays to treat various ailments, particularly fever.

Authors+Show Affiliations

Faculty of Pharmacy, Universiti Teknologi MARA, 40450, Shah Alam, Selangor, Malaysia. shaza8174@yahoo.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18404320

Citation

Zakaria, Zainul Amiruddin, et al. "Antinociceptive, Anti-inflammatory, and Antipyretic Properties of an Aqueous Extract of Dicranopteris Linearis Leaves in Experimental Animal Models." Journal of Natural Medicines, vol. 62, no. 2, 2008, pp. 179-87.
Zakaria ZA, Ghani ZD, Nor RN, et al. Antinociceptive, anti-inflammatory, and antipyretic properties of an aqueous extract of Dicranopteris linearis leaves in experimental animal models. J Nat Med. 2008;62(2):179-87.
Zakaria, Z. A., Ghani, Z. D., Nor, R. N., Gopalan, H. K., Sulaiman, M. R., Jais, A. M., Somchit, M. N., Kader, A. A., & Ripin, J. (2008). Antinociceptive, anti-inflammatory, and antipyretic properties of an aqueous extract of Dicranopteris linearis leaves in experimental animal models. Journal of Natural Medicines, 62(2), 179-87. https://doi.org/10.1007/s11418-007-0224-x
Zakaria ZA, et al. Antinociceptive, Anti-inflammatory, and Antipyretic Properties of an Aqueous Extract of Dicranopteris Linearis Leaves in Experimental Animal Models. J Nat Med. 2008;62(2):179-87. PubMed PMID: 18404320.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Antinociceptive, anti-inflammatory, and antipyretic properties of an aqueous extract of Dicranopteris linearis leaves in experimental animal models. AU - Zakaria,Zainul Amiruddin, AU - Ghani,Zuleen Delina Fasya Abdul, AU - Nor,Raden Nur Suraya Raden Mohd, AU - Gopalan,Hanan Kumar, AU - Sulaiman,Mohd Roslan, AU - Jais,Abdul Manan Mat, AU - Somchit,Muhammad Nazrul, AU - Kader,Arifah Abdul, AU - Ripin,Johari, Y1 - 2008/01/12/ PY - 2007/02/26/received PY - 2007/12/10/accepted PY - 2008/4/12/pubmed PY - 2008/7/9/medline PY - 2008/4/12/entrez SP - 179 EP - 87 JF - Journal of natural medicines JO - J Nat Med VL - 62 IS - 2 N2 - This study was performed out to establish the antinociceptive, anti-inflammatory, and antipyretic properties of an aqueous extract of Dicranopteris linearis leaves in experimental animals. The antinociceptive activity was measured using the abdominal constriction, hot plate, and formalin tests. The anti-inflammatory and antipyretic activities were measured using the carrageenan-induced paw edema and brewer's yeast-induced pyrexia tests, respectively. The extract, obtained after 72 h soaking of the air-dried leaves in distilled water and then prepared in the doses of 13.2, 66.0, 132.0, and 660.0 mg/kg, was administered subcutaneously 30 min before subjecting the animals to the assays mentioned above. Generally, the extract, at all doses used, was found to have significant (P < 0.05) concentration-independent antinociceptive, anti-inflammatory, and anti-pyretic activity. In conclusion, the aqueous extract of D. linearis has antinociceptive, anti-inflammatory, and antipyretic activity, supporting previous claims of its traditional use by the Malays to treat various ailments, particularly fever. SN - 1861-0293 UR - https://www.unboundmedicine.com/medline/citation/18404320/Antinociceptive_anti_inflammatory_and_antipyretic_properties_of_an_aqueous_extract_of_Dicranopteris_linearis_leaves_in_experimental_animal_models_ L2 - https://dx.doi.org/10.1007/s11418-007-0224-x DB - PRIME DP - Unbound Medicine ER -