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Antinociceptive and anti-inflammatory activities of the aqueous extract of Kaempferia galanga leaves in animal models.
J Nat Med. 2008 Apr; 62(2):221-7.JN

Abstract

This study was performed to determine the antinociceptive and anti-inflammatory activities of aqueous extract of Kaempferia galanga leaves using various animal models. The extract, in the doses of 30, 100, and 300 mg/kg, was prepared by soaking (1:10; w/v) the air-dried powdered leaves (40 g) in distilled water (dH(2)O) for 72 h and administered subcutaneously in mice/rats 30 min prior to the tests. The extract exhibited significant (P < 0.05) antinociceptive activity when assessed using the abdominal constriction, hot-plate and formalin tests, with activity observed in all tests occurring in a dose-dependent manner. Furthermore, the antinociceptive activity of K. galanga extract was significantly (P < 0.05) reversed when prechallenged with 10 mg/kg naloxone. The extract also produced a significantly (P < 0.05) dose-dependent anti-inflammatory activity when assessed using the carrageenan-induced paw-edema test. In conclusion, this study demonstrated that K. galanga leaves possessed antinociceptive and anti-inflammatory activities and thus supports the Malay's traditional uses of the plant for treatments of mouth ulcer, headache, sore throat, etc.

Authors+Show Affiliations

Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, 43400 UPM Serdang, Selangor, Malaysia. mrs@medic.upm.edu.myNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18404328

Citation

Sulaiman, M R., et al. "Antinociceptive and Anti-inflammatory Activities of the Aqueous Extract of Kaempferia Galanga Leaves in Animal Models." Journal of Natural Medicines, vol. 62, no. 2, 2008, pp. 221-7.
Sulaiman MR, Zakaria ZA, Daud IA, et al. Antinociceptive and anti-inflammatory activities of the aqueous extract of Kaempferia galanga leaves in animal models. J Nat Med. 2008;62(2):221-7.
Sulaiman, M. R., Zakaria, Z. A., Daud, I. A., Ng, F. N., Ng, Y. C., & Hidayat, M. T. (2008). Antinociceptive and anti-inflammatory activities of the aqueous extract of Kaempferia galanga leaves in animal models. Journal of Natural Medicines, 62(2), 221-7. https://doi.org/10.1007/s11418-007-0210-3
Sulaiman MR, et al. Antinociceptive and Anti-inflammatory Activities of the Aqueous Extract of Kaempferia Galanga Leaves in Animal Models. J Nat Med. 2008;62(2):221-7. PubMed PMID: 18404328.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Antinociceptive and anti-inflammatory activities of the aqueous extract of Kaempferia galanga leaves in animal models. AU - Sulaiman,M R, AU - Zakaria,Z A, AU - Daud,I A, AU - Ng,F N, AU - Ng,Y C, AU - Hidayat,M T, Y1 - 2007/11/29/ PY - 2007/06/11/received PY - 2007/10/19/accepted PY - 2008/4/12/pubmed PY - 2008/7/9/medline PY - 2008/4/12/entrez SP - 221 EP - 7 JF - Journal of natural medicines JO - J Nat Med VL - 62 IS - 2 N2 - This study was performed to determine the antinociceptive and anti-inflammatory activities of aqueous extract of Kaempferia galanga leaves using various animal models. The extract, in the doses of 30, 100, and 300 mg/kg, was prepared by soaking (1:10; w/v) the air-dried powdered leaves (40 g) in distilled water (dH(2)O) for 72 h and administered subcutaneously in mice/rats 30 min prior to the tests. The extract exhibited significant (P < 0.05) antinociceptive activity when assessed using the abdominal constriction, hot-plate and formalin tests, with activity observed in all tests occurring in a dose-dependent manner. Furthermore, the antinociceptive activity of K. galanga extract was significantly (P < 0.05) reversed when prechallenged with 10 mg/kg naloxone. The extract also produced a significantly (P < 0.05) dose-dependent anti-inflammatory activity when assessed using the carrageenan-induced paw-edema test. In conclusion, this study demonstrated that K. galanga leaves possessed antinociceptive and anti-inflammatory activities and thus supports the Malay's traditional uses of the plant for treatments of mouth ulcer, headache, sore throat, etc. SN - 1861-0293 UR - https://www.unboundmedicine.com/medline/citation/18404328/Antinociceptive_and_anti_inflammatory_activities_of_the_aqueous_extract_of_Kaempferia_galanga_leaves_in_animal_models_ L2 - https://dx.doi.org/10.1007/s11418-007-0210-3 DB - PRIME DP - Unbound Medicine ER -