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The role of elastin and collagen in cutaneous aging: intrinsic aging versus photoexposure.
J Drugs Dermatol. 2008 Feb; 7(2 Suppl):s12-6.JD

Abstract

Cutaneous aging occurs through 2 biologically distinct processes: intrinsic and extrinsic aging. The first is a naturally occurring process that results from slow tissue degeneration. In human dermis, intrinsic aging is characterized by 3 features: atrophy of the dermis due to loss of collagen, degeneration in the elastic fiber network, and loss of hydration. In contrast to intrinsic aging, extrinsic aging is due to environmental factors. Since ultraviolet (UV) exposure is the principal cause of extrinsic aging, it is often referred to as photoaging. At the microscopic level, the distinguishing feature of photoaging is a massive accumulation of elastotic material in the upper and middle dermis, a process termed solar elastosis. Using recombinant DNA technology, it has become possible to demonstrate that UV radiation can activate the human elastin promoter. This provides a mechanism for enhanced elastin biosynthesis, which contributes to the clinical and morphologic changes observed in photoaged skin.

Authors+Show Affiliations

Department of Dermatology and Cutaneous Biology, Jefferson Medical College, Philadelphia, PA, USA.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

18404866

Citation

Uitto, Jouni. "The Role of Elastin and Collagen in Cutaneous Aging: Intrinsic Aging Versus Photoexposure." Journal of Drugs in Dermatology : JDD, vol. 7, no. 2 Suppl, 2008, pp. s12-6.
Uitto J. The role of elastin and collagen in cutaneous aging: intrinsic aging versus photoexposure. J Drugs Dermatol. 2008;7(2 Suppl):s12-6.
Uitto, J. (2008). The role of elastin and collagen in cutaneous aging: intrinsic aging versus photoexposure. Journal of Drugs in Dermatology : JDD, 7(2 Suppl), s12-6.
Uitto J. The Role of Elastin and Collagen in Cutaneous Aging: Intrinsic Aging Versus Photoexposure. J Drugs Dermatol. 2008;7(2 Suppl):s12-6. PubMed PMID: 18404866.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The role of elastin and collagen in cutaneous aging: intrinsic aging versus photoexposure. A1 - Uitto,Jouni, PY - 2008/4/15/pubmed PY - 2008/5/13/medline PY - 2008/4/15/entrez SP - s12 EP - 6 JF - Journal of drugs in dermatology : JDD JO - J Drugs Dermatol VL - 7 IS - 2 Suppl N2 - Cutaneous aging occurs through 2 biologically distinct processes: intrinsic and extrinsic aging. The first is a naturally occurring process that results from slow tissue degeneration. In human dermis, intrinsic aging is characterized by 3 features: atrophy of the dermis due to loss of collagen, degeneration in the elastic fiber network, and loss of hydration. In contrast to intrinsic aging, extrinsic aging is due to environmental factors. Since ultraviolet (UV) exposure is the principal cause of extrinsic aging, it is often referred to as photoaging. At the microscopic level, the distinguishing feature of photoaging is a massive accumulation of elastotic material in the upper and middle dermis, a process termed solar elastosis. Using recombinant DNA technology, it has become possible to demonstrate that UV radiation can activate the human elastin promoter. This provides a mechanism for enhanced elastin biosynthesis, which contributes to the clinical and morphologic changes observed in photoaged skin. SN - 1545-9616 UR - https://www.unboundmedicine.com/medline/citation/18404866/The_role_of_elastin_and_collagen_in_cutaneous_aging:_intrinsic_aging_versus_photoexposure_ L2 - https://medlineplus.gov/skinaging.html DB - PRIME DP - Unbound Medicine ER -
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