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[Effect of Helicobacter pylori eradication on iron deficiency anemia of unknown origin].
Gastroenterol Hepatol. 2008 Apr; 31(4):213-6.GH

Abstract

Iron deficiency anemia of unknown origin is a frequent cause of anemia in which etiological diagnosis is often not achieved, despite currently available diagnostic techniques. Recent studies suggest that, in the absence of digestive tract lesions, Helicobacter pylori infection could be the cause of iron deficiency anemia, due to the alterations produced in gastric iron absorption.

OBJECTIVES

To evaluate whether H. pylori eradication resolves iron deficiency anemia and removes the need for oral iron administration.

PATIENTS AND METHODS

We performed an observational descriptive study in patients with iron deficiency anemia refractory to treatment with oral iron administration and with out causes that could explain their anemia. Gastroscopy, ileocolonoscopy, intestinal transit study and/or endoscopic capsule were performed. Female patients also underwent gynecological study. All patients were H. pylori-positive and standard eradication therapy was administered until elimination was achieved. The patients were followed-up for a minimum of 3 months after H. pylori eradication and the need for oral iron intake after eradication was evaluated.

RESULTS

Ten patients, aged 53+/-8.2 years, were included. Hemoglobin (Hbg) before treatment was 10.06+/-0.53 mg/dl, mean corpuscular volume (MCV) was 75.43+/-6.02 fl and ferritin was 6.1+/-3.28 ng/ml. Eradication therapy was administered until elimination of H. pylori. The mean time before disappearance of anemia was 4.5 months. Laboratory parameters after treatment were as follows: Hgb 12.86+/-0.75 mg/dl, MCV 85.02+/-4.8 fl and ferritin 28+/-22.19 ng/dl.

CONCLUSIONS

In the absence of lesions that could explain iron deficiency anemia, this disease can be related to H. pylori infection. Eradication of this infection is closely followed by disappearance of anemia and ferropenia.

Authors+Show Affiliations

Servicio de Aparato Digestivo, Hospital General La Mancha Centro, Alcázar de San Juan, Ciudad Real, Spain. perezrold@teleline.esNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Evaluation Study
Journal Article

Language

spa

PubMed ID

18405485

Citation

Pérez Roldán, Francisco, et al. "[Effect of Helicobacter Pylori Eradication On Iron Deficiency Anemia of Unknown Origin]." Gastroenterologia Y Hepatologia, vol. 31, no. 4, 2008, pp. 213-6.
Pérez Roldán F, Castellanos Monedero JJ, González Carro P, et al. [Effect of Helicobacter pylori eradication on iron deficiency anemia of unknown origin]. Gastroenterol Hepatol. 2008;31(4):213-6.
Pérez Roldán, F., Castellanos Monedero, J. J., González Carro, P., Villafáñez García, M. C., Roncero García-Escribano, O., Legaz Huidobro, M. L., & Ruiz Carrillo, F. (2008). [Effect of Helicobacter pylori eradication on iron deficiency anemia of unknown origin]. Gastroenterologia Y Hepatologia, 31(4), 213-6.
Pérez Roldán F, et al. [Effect of Helicobacter Pylori Eradication On Iron Deficiency Anemia of Unknown Origin]. Gastroenterol Hepatol. 2008;31(4):213-6. PubMed PMID: 18405485.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Effect of Helicobacter pylori eradication on iron deficiency anemia of unknown origin]. AU - Pérez Roldán,Francisco, AU - Castellanos Monedero,Jesús Javier, AU - González Carro,Pedro, AU - Villafáñez García,María Concepción, AU - Roncero García-Escribano,Oscar, AU - Legaz Huidobro,María Luisa, AU - Ruiz Carrillo,Francisco, PY - 2008/4/15/pubmed PY - 2008/10/10/medline PY - 2008/4/15/entrez SP - 213 EP - 6 JF - Gastroenterologia y hepatologia JO - Gastroenterol Hepatol VL - 31 IS - 4 N2 - UNLABELLED: Iron deficiency anemia of unknown origin is a frequent cause of anemia in which etiological diagnosis is often not achieved, despite currently available diagnostic techniques. Recent studies suggest that, in the absence of digestive tract lesions, Helicobacter pylori infection could be the cause of iron deficiency anemia, due to the alterations produced in gastric iron absorption. OBJECTIVES: To evaluate whether H. pylori eradication resolves iron deficiency anemia and removes the need for oral iron administration. PATIENTS AND METHODS: We performed an observational descriptive study in patients with iron deficiency anemia refractory to treatment with oral iron administration and with out causes that could explain their anemia. Gastroscopy, ileocolonoscopy, intestinal transit study and/or endoscopic capsule were performed. Female patients also underwent gynecological study. All patients were H. pylori-positive and standard eradication therapy was administered until elimination was achieved. The patients were followed-up for a minimum of 3 months after H. pylori eradication and the need for oral iron intake after eradication was evaluated. RESULTS: Ten patients, aged 53+/-8.2 years, were included. Hemoglobin (Hbg) before treatment was 10.06+/-0.53 mg/dl, mean corpuscular volume (MCV) was 75.43+/-6.02 fl and ferritin was 6.1+/-3.28 ng/ml. Eradication therapy was administered until elimination of H. pylori. The mean time before disappearance of anemia was 4.5 months. Laboratory parameters after treatment were as follows: Hgb 12.86+/-0.75 mg/dl, MCV 85.02+/-4.8 fl and ferritin 28+/-22.19 ng/dl. CONCLUSIONS: In the absence of lesions that could explain iron deficiency anemia, this disease can be related to H. pylori infection. Eradication of this infection is closely followed by disappearance of anemia and ferropenia. SN - 0210-5705 UR - https://www.unboundmedicine.com/medline/citation/18405485/[Effect_of_Helicobacter_pylori_eradication_on_iron_deficiency_anemia_of_unknown_origin]_ L2 - http://www.elsevier.es/en/linksolver/ft/ivp/0210-5705/31/213 DB - PRIME DP - Unbound Medicine ER -