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Gallstones, cholecystectomy and irritable bowel syndrome (IBS) MICOL population-based study.
Dig Liver Dis 2008; 40(12):944-50DL

Abstract

BACKGROUND

Subjects with irritable bowel syndrome may undergo an excess of cholecystectomy. It is not known, however, whether the cholecystectomy rate parallels an increased risk of gallstones.

AIM

Aim was to assess the prevalence and the incidence of gallstones and cholecystectomy in subjects with irritable bowel syndrome symptoms.

SUBJECTS AND METHODS

In this population-based study, 29,139 subjects (63.2% of 46,139 randomly selected subjects, age 30-69 years) underwent a physical examination, an interview on gastrointestinal symptoms and an upper abdominal ultrasonography. An identical survey was carried out 7.8+/-1.0 (M+/-S.D.) years later on 8460 gallstone-free subjects at the first survey. Prevalence and incidence of gallstones and cholecystectomy were assessed in subjects with (1) irritable bowel syndrome; (2) abdominal pain and normal bowel; (3) altered bowel and no abdominal pain and (4) asymptomatic controls; univariate and multivariate regression logistic models were used for statistical analysis.

RESULTS

Prevalence odds of gallstones and cholecystectomy were significantly higher in irritable bowel syndrome and abdominal pain and normal bowel than in controls. Irritable bowel syndrome and abdominal pain and normal bowel subjects were more aware of gallstones than controls (p<0.001), and the prevalence of gallstones in irritable bowel syndrome subjects unaware of their gallbladder status was not significantly different from the controls. The incidence of gallstone disease in irritable bowel syndrome, abdominal pain and normal bowel, and altered bowel and no abdominal pain subjects did not differ from the controls. The incidence of cholecystectomy was higher in irritable bowel syndrome and abdominal pain and normal bowel groups than in controls and altered bowel and no abdominal pain group.

CONCLUSIONS

Irritable bowel syndrome subjects have an increased risk of cholecystectomy that is not due to an increased risk of gallstones, but rather to abdominal pain, awareness of having gallstones, and inappropriate surgical indications.

Authors+Show Affiliations

Department of Clinical Science, University Sapienza, Rome, Italy. enrico.corazziari@uniroma1.itNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

18406218

Citation

Corazziari, E, et al. "Gallstones, Cholecystectomy and Irritable Bowel Syndrome (IBS) MICOL Population-based Study." Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver, vol. 40, no. 12, 2008, pp. 944-50.
Corazziari E, Attili AF, Angeletti C, et al. Gallstones, cholecystectomy and irritable bowel syndrome (IBS) MICOL population-based study. Dig Liver Dis. 2008;40(12):944-50.
Corazziari, E., Attili, A. F., Angeletti, C., & De Santis, A. (2008). Gallstones, cholecystectomy and irritable bowel syndrome (IBS) MICOL population-based study. Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver, 40(12), pp. 944-50. doi:10.1016/j.dld.2008.02.013.
Corazziari E, et al. Gallstones, Cholecystectomy and Irritable Bowel Syndrome (IBS) MICOL Population-based Study. Dig Liver Dis. 2008;40(12):944-50. PubMed PMID: 18406218.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Gallstones, cholecystectomy and irritable bowel syndrome (IBS) MICOL population-based study. AU - Corazziari,E, AU - Attili,A F, AU - Angeletti,C, AU - De Santis,A, Y1 - 2008/04/10/ PY - 2005/12/20/received PY - 2008/02/14/revised PY - 2008/02/15/accepted PY - 2008/4/15/pubmed PY - 2009/3/26/medline PY - 2008/4/15/entrez SP - 944 EP - 50 JF - Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver JO - Dig Liver Dis VL - 40 IS - 12 N2 - BACKGROUND: Subjects with irritable bowel syndrome may undergo an excess of cholecystectomy. It is not known, however, whether the cholecystectomy rate parallels an increased risk of gallstones. AIM: Aim was to assess the prevalence and the incidence of gallstones and cholecystectomy in subjects with irritable bowel syndrome symptoms. SUBJECTS AND METHODS: In this population-based study, 29,139 subjects (63.2% of 46,139 randomly selected subjects, age 30-69 years) underwent a physical examination, an interview on gastrointestinal symptoms and an upper abdominal ultrasonography. An identical survey was carried out 7.8+/-1.0 (M+/-S.D.) years later on 8460 gallstone-free subjects at the first survey. Prevalence and incidence of gallstones and cholecystectomy were assessed in subjects with (1) irritable bowel syndrome; (2) abdominal pain and normal bowel; (3) altered bowel and no abdominal pain and (4) asymptomatic controls; univariate and multivariate regression logistic models were used for statistical analysis. RESULTS: Prevalence odds of gallstones and cholecystectomy were significantly higher in irritable bowel syndrome and abdominal pain and normal bowel than in controls. Irritable bowel syndrome and abdominal pain and normal bowel subjects were more aware of gallstones than controls (p<0.001), and the prevalence of gallstones in irritable bowel syndrome subjects unaware of their gallbladder status was not significantly different from the controls. The incidence of gallstone disease in irritable bowel syndrome, abdominal pain and normal bowel, and altered bowel and no abdominal pain subjects did not differ from the controls. The incidence of cholecystectomy was higher in irritable bowel syndrome and abdominal pain and normal bowel groups than in controls and altered bowel and no abdominal pain group. CONCLUSIONS: Irritable bowel syndrome subjects have an increased risk of cholecystectomy that is not due to an increased risk of gallstones, but rather to abdominal pain, awareness of having gallstones, and inappropriate surgical indications. SN - 1878-3562 UR - https://www.unboundmedicine.com/medline/citation/18406218/Gallstones_cholecystectomy_and_irritable_bowel_syndrome__IBS__MICOL_population_based_study_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1590-8658(08)00071-6 DB - PRIME DP - Unbound Medicine ER -