Tags

Type your tag names separated by a space and hit enter

Low plasma brain-derived neurotrophic factor and childhood physical neglect are associated with verbal memory impairment in major depression--a preliminary report.
Biol Psychiatry. 2008 Aug 15; 64(4):281-5.BP

Abstract

BACKGROUND

Early life stress has been suggested to mediate vulnerability to affective disorders. Animal models of repeated maternal separation have shown reduced brain-derived neurotrophic factor (BDNF) levels in specific brain regions implicated with hypothalamic-pituitary-adrenal axis and memory formation. In addition, BDNF levels are also reduced in major depressive disorder (MDD) and bipolar disorder. The aim of this study was to investigate whether childhood physical neglect (CPN) and plasma BDNF levels would impact on memory performance in adult female subjects with recurrent major depression.

METHODS

Recurrent female MDD outpatients with CPN (MDD + CPN, n = 17) and without CPN (MDD, n = 17) and healthy control subjects (n = 15) were assessed for plasma BDNF content and verbal memory performance. Memory was assessed through the logical memory component of the Weschler Memory Scale-Revised for immediate and delayed recall. Brain-derived neurotrophic factor was assessed with enzyme-linked immunosorbent assays (ELISAs).

RESULTS

Major depressive disorder patients showed lower plasma BDNF concentrations than healthy control subjects (p < .001). Major depressive disorder + CPN had even lower BDNF levels compared with control subjects and MDD (p < .05). Brain-derived neurotrophic factor levels were negatively related to psychological morbidity and positively correlated to memory performance. Regression models showed that severity of self-reported CPN and low plasma BDNF predicted impairment on immediate verbal recall. Delayed recall impairment was predicted by severity of CPN and depression and memory retention by posttraumatic stress disorder (PTSD) severity symptoms.

CONCLUSIONS

Our data suggest that CPN and plasma BDNF are important factors associated with depression and verbal memory performance, particularly with encoding processes.

Links

Publisher Full Text (DOI)

Authors+Show Affiliations

Grassi-Oliveira R
Faculty of Psychology, Pontifical Catholic University of Rio Grande do Sul (PUCRS), Porto Alegre, Brazil.
Stein LM
No affiliation info available
Lopes RP
No affiliation info available
Teixeira AL
No affiliation info available
Bauer ME
No affiliation info available

MeSH

AdultAnalysis of VarianceBrain-Derived Neurotrophic FactorChildChild AbuseDepressive Disorder, MajorEnzyme-Linked Immunosorbent AssayFemaleHumansMemory DisordersMiddle AgedNeuropsychological TestsOutpatientsSurveys and QuestionnairesVerbal Learning

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18406398

Citation

Grassi-Oliveira, Rodrigo, et al. "Low Plasma Brain-derived Neurotrophic Factor and Childhood Physical Neglect Are Associated With Verbal Memory Impairment in Major Depression--a Preliminary Report." Biological Psychiatry, vol. 64, no. 4, 2008, pp. 281-5.
Grassi-Oliveira R, Stein LM, Lopes RP, et al. Low plasma brain-derived neurotrophic factor and childhood physical neglect are associated with verbal memory impairment in major depression--a preliminary report. Biol Psychiatry. 2008;64(4):281-5.
Grassi-Oliveira, R., Stein, L. M., Lopes, R. P., Teixeira, A. L., & Bauer, M. E. (2008). Low plasma brain-derived neurotrophic factor and childhood physical neglect are associated with verbal memory impairment in major depression--a preliminary report. Biological Psychiatry, 64(4), 281-5. https://doi.org/10.1016/j.biopsych.2008.02.023
Grassi-Oliveira R, et al. Low Plasma Brain-derived Neurotrophic Factor and Childhood Physical Neglect Are Associated With Verbal Memory Impairment in Major Depression--a Preliminary Report. Biol Psychiatry. 2008 Aug 15;64(4):281-5. PubMed PMID: 18406398.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Low plasma brain-derived neurotrophic factor and childhood physical neglect are associated with verbal memory impairment in major depression--a preliminary report. AU - Grassi-Oliveira,Rodrigo, AU - Stein,Lilian Milnitsky, AU - Lopes,Rodrigo Pestana, AU - Teixeira,Antonio L, AU - Bauer,Moisés Evandro, Y1 - 2008/04/11/ PY - 2007/10/05/received PY - 2008/01/29/revised PY - 2008/02/22/accepted PY - 2008/4/15/pubmed PY - 2008/11/4/medline PY - 2008/4/15/entrez SP - 281 EP - 5 JF - Biological psychiatry JO - Biol Psychiatry VL - 64 IS - 4 N2 - BACKGROUND: Early life stress has been suggested to mediate vulnerability to affective disorders. Animal models of repeated maternal separation have shown reduced brain-derived neurotrophic factor (BDNF) levels in specific brain regions implicated with hypothalamic-pituitary-adrenal axis and memory formation. In addition, BDNF levels are also reduced in major depressive disorder (MDD) and bipolar disorder. The aim of this study was to investigate whether childhood physical neglect (CPN) and plasma BDNF levels would impact on memory performance in adult female subjects with recurrent major depression. METHODS: Recurrent female MDD outpatients with CPN (MDD + CPN, n = 17) and without CPN (MDD, n = 17) and healthy control subjects (n = 15) were assessed for plasma BDNF content and verbal memory performance. Memory was assessed through the logical memory component of the Weschler Memory Scale-Revised for immediate and delayed recall. Brain-derived neurotrophic factor was assessed with enzyme-linked immunosorbent assays (ELISAs). RESULTS: Major depressive disorder patients showed lower plasma BDNF concentrations than healthy control subjects (p < .001). Major depressive disorder + CPN had even lower BDNF levels compared with control subjects and MDD (p < .05). Brain-derived neurotrophic factor levels were negatively related to psychological morbidity and positively correlated to memory performance. Regression models showed that severity of self-reported CPN and low plasma BDNF predicted impairment on immediate verbal recall. Delayed recall impairment was predicted by severity of CPN and depression and memory retention by posttraumatic stress disorder (PTSD) severity symptoms. CONCLUSIONS: Our data suggest that CPN and plasma BDNF are important factors associated with depression and verbal memory performance, particularly with encoding processes. SN - 1873-2402 UR - https://www.unboundmedicine.com/medline/citation/18406398/Low_plasma_brain_derived_neurotrophic_factor_and_childhood_physical_neglect_are_associated_with_verbal_memory_impairment_in_major_depression__a_preliminary_report_ DB - PRIME DP - Unbound Medicine ER -