Tags

Type your tag names separated by a space and hit enter

Combined antipsychotic treatment involving clozapine and aripiprazole.
Prog Neuropsychopharmacol Biol Psychiatry. 2008 Aug 01; 32(6):1386-92.PN

Abstract

Treatment resistance is considered a challenging problem of antipsychotic pharmacotherapy. In such cases, combination approaches are commonly used, for instance the add-on of aripiprazole to clozapine. This review aims at giving an overview of the present knowledge on this strategy. We performed a keyword-based screening of databases (including November 2007) and evaluated the data in a systematic manner. The courses of 94 patients were reported in 11 publications. At a mean dosage of 20.5 mg/day, aripiprazole achieved clinical improvement of psychotic symptoms and facilitated a dose reduction of clozapine from 476.7 to 425.1 mg/day. In parallel, clozapine serum levels decreased from 611 to 523 ng/ml. No pharmacokinetic interactions were reported, and clozapine-induced side effects ameliorated. However, single cases of extrapyramidal side effects occurred. The combination of clozapine and aripiprazole follows a neurobiological rationale and appears to be effective and tolerable. The results of placebo-controlled trials might allow further insight into the benefits and risks of this strategy.

Authors+Show Affiliations

Central Institute of Mental Health, Department of Psychiatry and Psychotherapy, University of Heidelberg, Mannheim, Germany.No affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

18407391

Citation

Englisch, Susanne, and Mathias Zink. "Combined Antipsychotic Treatment Involving Clozapine and Aripiprazole." Progress in Neuro-psychopharmacology & Biological Psychiatry, vol. 32, no. 6, 2008, pp. 1386-92.
Englisch S, Zink M. Combined antipsychotic treatment involving clozapine and aripiprazole. Prog Neuropsychopharmacol Biol Psychiatry. 2008;32(6):1386-92.
Englisch, S., & Zink, M. (2008). Combined antipsychotic treatment involving clozapine and aripiprazole. Progress in Neuro-psychopharmacology & Biological Psychiatry, 32(6), 1386-92. https://doi.org/10.1016/j.pnpbp.2008.02.010
Englisch S, Zink M. Combined Antipsychotic Treatment Involving Clozapine and Aripiprazole. Prog Neuropsychopharmacol Biol Psychiatry. 2008 Aug 1;32(6):1386-92. PubMed PMID: 18407391.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Combined antipsychotic treatment involving clozapine and aripiprazole. AU - Englisch,Susanne, AU - Zink,Mathias, Y1 - 2008/02/29/ PY - 2008/01/18/received PY - 2008/02/18/revised PY - 2008/02/21/accepted PY - 2008/4/15/pubmed PY - 2008/10/23/medline PY - 2008/4/15/entrez SP - 1386 EP - 92 JF - Progress in neuro-psychopharmacology & biological psychiatry JO - Prog Neuropsychopharmacol Biol Psychiatry VL - 32 IS - 6 N2 - Treatment resistance is considered a challenging problem of antipsychotic pharmacotherapy. In such cases, combination approaches are commonly used, for instance the add-on of aripiprazole to clozapine. This review aims at giving an overview of the present knowledge on this strategy. We performed a keyword-based screening of databases (including November 2007) and evaluated the data in a systematic manner. The courses of 94 patients were reported in 11 publications. At a mean dosage of 20.5 mg/day, aripiprazole achieved clinical improvement of psychotic symptoms and facilitated a dose reduction of clozapine from 476.7 to 425.1 mg/day. In parallel, clozapine serum levels decreased from 611 to 523 ng/ml. No pharmacokinetic interactions were reported, and clozapine-induced side effects ameliorated. However, single cases of extrapyramidal side effects occurred. The combination of clozapine and aripiprazole follows a neurobiological rationale and appears to be effective and tolerable. The results of placebo-controlled trials might allow further insight into the benefits and risks of this strategy. SN - 0278-5846 UR - https://www.unboundmedicine.com/medline/citation/18407391/Combined_antipsychotic_treatment_involving_clozapine_and_aripiprazole_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0278-5846(08)00071-7 DB - PRIME DP - Unbound Medicine ER -