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Double dissociation of 'what' and 'where' processing in auditory cortex.
Nat Neurosci. 2008 May; 11(5):609-16.NN

Abstract

Studies of cortical connections or neuronal function in different cerebral areas support the hypothesis that parallel cortical processing streams, similar to those identified in visual cortex, may exist in the auditory system. However, this model has not yet been behaviorally tested. We used reversible cooling deactivation to investigate whether the individual regions in cat nonprimary auditory cortex that are responsible for processing the pattern of an acoustic stimulus or localizing a sound in space could be doubly dissociated in the same animal. We found that bilateral deactivation of the posterior auditory field resulted in deficits in a sound-localization task, whereas bilateral deactivation of the anterior auditory field resulted in deficits in a pattern-discrimination task, but not vice versa. These findings support a model of cortical organization that proposes that identifying an acoustic stimulus ('what') and its spatial location ('where') are processed in separate streams in auditory cortex.

Authors+Show Affiliations

Centre for Brain and Mind, Department of Physiology and Pharmacology, Schulich School of Medicine and Dentistry, University of Western Ontario, Middlesex Road, London, Ontario N6A 5K8, Canada. steve.lomber@uwo.caNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18408717

Citation

Lomber, Stephen G., and Shveta Malhotra. "Double Dissociation of 'what' and 'where' Processing in Auditory Cortex." Nature Neuroscience, vol. 11, no. 5, 2008, pp. 609-16.
Lomber SG, Malhotra S. Double dissociation of 'what' and 'where' processing in auditory cortex. Nat Neurosci. 2008;11(5):609-16.
Lomber, S. G., & Malhotra, S. (2008). Double dissociation of 'what' and 'where' processing in auditory cortex. Nature Neuroscience, 11(5), 609-16. https://doi.org/10.1038/nn.2108
Lomber SG, Malhotra S. Double Dissociation of 'what' and 'where' Processing in Auditory Cortex. Nat Neurosci. 2008;11(5):609-16. PubMed PMID: 18408717.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Double dissociation of 'what' and 'where' processing in auditory cortex. AU - Lomber,Stephen G, AU - Malhotra,Shveta, Y1 - 2008/04/13/ PY - 2008/02/01/received PY - 2008/03/13/accepted PY - 2008/4/15/pubmed PY - 2008/7/1/medline PY - 2008/4/15/entrez SP - 609 EP - 16 JF - Nature neuroscience JO - Nat Neurosci VL - 11 IS - 5 N2 - Studies of cortical connections or neuronal function in different cerebral areas support the hypothesis that parallel cortical processing streams, similar to those identified in visual cortex, may exist in the auditory system. However, this model has not yet been behaviorally tested. We used reversible cooling deactivation to investigate whether the individual regions in cat nonprimary auditory cortex that are responsible for processing the pattern of an acoustic stimulus or localizing a sound in space could be doubly dissociated in the same animal. We found that bilateral deactivation of the posterior auditory field resulted in deficits in a sound-localization task, whereas bilateral deactivation of the anterior auditory field resulted in deficits in a pattern-discrimination task, but not vice versa. These findings support a model of cortical organization that proposes that identifying an acoustic stimulus ('what') and its spatial location ('where') are processed in separate streams in auditory cortex. SN - 1097-6256 UR - https://www.unboundmedicine.com/medline/citation/18408717/Double_dissociation_of_'what'_and_'where'_processing_in_auditory_cortex_ L2 - https://doi.org/10.1038/nn.2108 DB - PRIME DP - Unbound Medicine ER -