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[Idiopathic hyperuricemia with overproduction of uric acid].
Nihon Rinsho. 2008 Apr; 66(4):675-8.NR

Abstract

Idiopathic hyperuricemia is generally defined as hyperuricemia caused by unknown origin. Idiopathic hyperuricemia is categorized as overproducing or underexcretion of uric acid. Overproduced uric acid is caused by increased biosynthesis of purine bodies, hypermetabolization of purine bodies, or increased intake of dietary purine bodies. Idiopathic hyperuricemia with overproducing uric acid can be diagnosed by amount of excreted uric acid in the urine. Recently it has been identified that hypertension are frequently associated with myogenic hyperuricemia converted from overproduced hypoxanthine in the skeletal muscles. Some anti-hypertensive drugs including alpha1 blocker, ACE inhibitor, alphabeta blocker, or long-acting Ca blocker attenuated the myogenic hyperuricemia. Thus, these drugs may be helpful in the management of hypertension with hyperuricemia.

Authors+Show Affiliations

Division of Molecular Medicine and Therapeutics, Department of Multidisciplinary Internal Medicine, Tottori University Faculty of Medicine.No affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article
Review

Language

jpn

PubMed ID

18409513

Citation

Mizuta, Einosuke, et al. "[Idiopathic Hyperuricemia With Overproduction of Uric Acid]." Nihon Rinsho. Japanese Journal of Clinical Medicine, vol. 66, no. 4, 2008, pp. 675-8.
Mizuta E, Igawa O, Hisatome I. [Idiopathic hyperuricemia with overproduction of uric acid]. Nihon Rinsho. 2008;66(4):675-8.
Mizuta, E., Igawa, O., & Hisatome, I. (2008). [Idiopathic hyperuricemia with overproduction of uric acid]. Nihon Rinsho. Japanese Journal of Clinical Medicine, 66(4), 675-8.
Mizuta E, Igawa O, Hisatome I. [Idiopathic Hyperuricemia With Overproduction of Uric Acid]. Nihon Rinsho. 2008;66(4):675-8. PubMed PMID: 18409513.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Idiopathic hyperuricemia with overproduction of uric acid]. AU - Mizuta,Einosuke, AU - Igawa,Osamu, AU - Hisatome,Ichiro, PY - 2008/4/16/pubmed PY - 2008/5/31/medline PY - 2008/4/16/entrez SP - 675 EP - 8 JF - Nihon rinsho. Japanese journal of clinical medicine JO - Nihon Rinsho VL - 66 IS - 4 N2 - Idiopathic hyperuricemia is generally defined as hyperuricemia caused by unknown origin. Idiopathic hyperuricemia is categorized as overproducing or underexcretion of uric acid. Overproduced uric acid is caused by increased biosynthesis of purine bodies, hypermetabolization of purine bodies, or increased intake of dietary purine bodies. Idiopathic hyperuricemia with overproducing uric acid can be diagnosed by amount of excreted uric acid in the urine. Recently it has been identified that hypertension are frequently associated with myogenic hyperuricemia converted from overproduced hypoxanthine in the skeletal muscles. Some anti-hypertensive drugs including alpha1 blocker, ACE inhibitor, alphabeta blocker, or long-acting Ca blocker attenuated the myogenic hyperuricemia. Thus, these drugs may be helpful in the management of hypertension with hyperuricemia. SN - 0047-1852 UR - https://www.unboundmedicine.com/medline/citation/18409513/[Idiopathic_hyperuricemia_with_overproduction_of_uric_acid]_ DB - PRIME DP - Unbound Medicine ER -
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