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Longitudinal analysis of resting energy expenditure in patients with cystic fibrosis.
J Pediatr 2008; 152(5):703-8JPed

Abstract

OBJECTIVE

To assess whether elevated resting energy expenditure (REE) in female patients with cystic fibrosis (CF) persists longitudinally during late childhood and puberty.

STUDY DESIGN

REE and body composition were measured 3 times in 2 years in 86 children with CF. Pubertal status, bacterial colonization, liver disease, pancreatic and pulmonary function, and genotype were determined, and linear mixed model analyses were used to determine predictors and changes in REE longitudinally.

RESULTS

REE did not change with time allowing for fat free mass, pancreatic insufficiency (PI), or severe mutations. Pulmonary function and liver disease were not significant predictors of REE. Percentage predicted REE compared with control data was higher (P = .002) in female patients with CF (109.5%) and lower in male patients with CF (104%) and persisted with time. In post-menarchal female patients with CF, REE adjusted for fat free mass was 366 kJ/d lower than in pre-menarchal female patients, but still 112% predicted.

CONCLUSIONS

This longitudinal study demonstrates that REE is elevated in patients with CF with PI and severe mutations. The elevation of percentage predicted REE was greater in female patients than male patients and persisted for 2 years, and during pubertal maturation, independent of pulmonary and liver disease. These results highlight the need for a high-energy diet throughout childhood and adolescence, particularly in female patients with PI.

Authors+Show Affiliations

Department of Gastroenterology, The Children's Hospital at Westmead, Sydney, Australia.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18410778

Citation

Magoffin, Annabel, et al. "Longitudinal Analysis of Resting Energy Expenditure in Patients With Cystic Fibrosis." The Journal of Pediatrics, vol. 152, no. 5, 2008, pp. 703-8.
Magoffin A, Allen JR, McCauley J, et al. Longitudinal analysis of resting energy expenditure in patients with cystic fibrosis. J Pediatr. 2008;152(5):703-8.
Magoffin, A., Allen, J. R., McCauley, J., Gruca, M. A., Peat, J., Van Asperen, P., & Gaskin, K. (2008). Longitudinal analysis of resting energy expenditure in patients with cystic fibrosis. The Journal of Pediatrics, 152(5), pp. 703-8. doi:10.1016/j.jpeds.2007.10.021.
Magoffin A, et al. Longitudinal Analysis of Resting Energy Expenditure in Patients With Cystic Fibrosis. J Pediatr. 2008;152(5):703-8. PubMed PMID: 18410778.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Longitudinal analysis of resting energy expenditure in patients with cystic fibrosis. AU - Magoffin,Annabel, AU - Allen,Jane R, AU - McCauley,James, AU - Gruca,Margie A, AU - Peat,Jenny, AU - Van Asperen,Peter, AU - Gaskin,Kevin, Y1 - 2007/12/21/ PY - 2007/01/13/received PY - 2007/08/13/revised PY - 2007/10/19/accepted PY - 2008/4/16/pubmed PY - 2008/5/7/medline PY - 2008/4/16/entrez SP - 703 EP - 8 JF - The Journal of pediatrics JO - J. Pediatr. VL - 152 IS - 5 N2 - OBJECTIVE: To assess whether elevated resting energy expenditure (REE) in female patients with cystic fibrosis (CF) persists longitudinally during late childhood and puberty. STUDY DESIGN: REE and body composition were measured 3 times in 2 years in 86 children with CF. Pubertal status, bacterial colonization, liver disease, pancreatic and pulmonary function, and genotype were determined, and linear mixed model analyses were used to determine predictors and changes in REE longitudinally. RESULTS: REE did not change with time allowing for fat free mass, pancreatic insufficiency (PI), or severe mutations. Pulmonary function and liver disease were not significant predictors of REE. Percentage predicted REE compared with control data was higher (P = .002) in female patients with CF (109.5%) and lower in male patients with CF (104%) and persisted with time. In post-menarchal female patients with CF, REE adjusted for fat free mass was 366 kJ/d lower than in pre-menarchal female patients, but still 112% predicted. CONCLUSIONS: This longitudinal study demonstrates that REE is elevated in patients with CF with PI and severe mutations. The elevation of percentage predicted REE was greater in female patients than male patients and persisted for 2 years, and during pubertal maturation, independent of pulmonary and liver disease. These results highlight the need for a high-energy diet throughout childhood and adolescence, particularly in female patients with PI. SN - 1097-6833 UR - https://www.unboundmedicine.com/medline/citation/18410778/Longitudinal_analysis_of_resting_energy_expenditure_in_patients_with_cystic_fibrosis_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0022-3476(07)00984-5 DB - PRIME DP - Unbound Medicine ER -