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The benefit of daily photoprotection.
J Am Acad Dermatol. 2008 May; 58(5 Suppl 2):S160-6.JA

Abstract

BACKGROUND

It is now recognized that both ultraviolet (UV)-A and UVB wavelengths participate in the generation of photodamaged human skin during sun exposure. During usual daily activities, an appropriate protection against solar UV exposure should prevent clinical, cellular, and molecular changes potentially leading to photoaging.

OBJECTIVE

This study was designed to evaluate in human beings the protection afforded by a day cream containing a photostable combination of UVB and UVA filters and thus protect against the UV-induced skin alterations.

RESULTS

In solar-simulated radiation exposed and unprotected skin sites we observed melanization. The epidermis revealed a significant increase in stratum corneum and stratum granulosum thickness. In the dermis, an enhanced expression of tenascin and a reduced expression of type I procollagen were evidenced just below the dermoepidermal junction. Although no change in elastic fibers in exposed buttock skin was seen, a slightly increased deposit of lysozyme and alpha-1 antitrypsin on elastin fibers was observed using immunofluorescence techniques. A day cream with photoprotection properties was shown to prevent all of the above-described alterations.

LIMITATIONS

This study was performed on a limited number of patients (n = 12) with specific characteristics (20-35 years old and skin type II and III). Two dermal alterations were evaluated by visual assessment and not by computer-assisted image analysis quantification.

CONCLUSION

Our in vivo results demonstrate the benefits of daily photoprotection using a day cream containing appropriate broad-spectrum sunscreens, which prevent solar UV-induced skin damages.

Authors+Show Affiliations

L'Oréal Recherche, Clichy, France. sseite@dca.loreal.comNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18410803

Citation

Seité, Sophie, and Anny M A. Fourtanier. "The Benefit of Daily Photoprotection." Journal of the American Academy of Dermatology, vol. 58, no. 5 Suppl 2, 2008, pp. S160-6.
Seité S, Fourtanier AM. The benefit of daily photoprotection. J Am Acad Dermatol. 2008;58(5 Suppl 2):S160-6.
Seité, S., & Fourtanier, A. M. (2008). The benefit of daily photoprotection. Journal of the American Academy of Dermatology, 58(5 Suppl 2), S160-6. https://doi.org/10.1016/j.jaad.2007.04.036
Seité S, Fourtanier AM. The Benefit of Daily Photoprotection. J Am Acad Dermatol. 2008;58(5 Suppl 2):S160-6. PubMed PMID: 18410803.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The benefit of daily photoprotection. AU - Seité,Sophie, AU - Fourtanier,Anny M A, PY - 2007/01/15/received PY - 2007/04/19/revised PY - 2007/04/24/accepted PY - 2008/4/25/pubmed PY - 2008/5/16/medline PY - 2008/4/25/entrez SP - S160 EP - 6 JF - Journal of the American Academy of Dermatology JO - J Am Acad Dermatol VL - 58 IS - 5 Suppl 2 N2 - BACKGROUND: It is now recognized that both ultraviolet (UV)-A and UVB wavelengths participate in the generation of photodamaged human skin during sun exposure. During usual daily activities, an appropriate protection against solar UV exposure should prevent clinical, cellular, and molecular changes potentially leading to photoaging. OBJECTIVE: This study was designed to evaluate in human beings the protection afforded by a day cream containing a photostable combination of UVB and UVA filters and thus protect against the UV-induced skin alterations. RESULTS: In solar-simulated radiation exposed and unprotected skin sites we observed melanization. The epidermis revealed a significant increase in stratum corneum and stratum granulosum thickness. In the dermis, an enhanced expression of tenascin and a reduced expression of type I procollagen were evidenced just below the dermoepidermal junction. Although no change in elastic fibers in exposed buttock skin was seen, a slightly increased deposit of lysozyme and alpha-1 antitrypsin on elastin fibers was observed using immunofluorescence techniques. A day cream with photoprotection properties was shown to prevent all of the above-described alterations. LIMITATIONS: This study was performed on a limited number of patients (n = 12) with specific characteristics (20-35 years old and skin type II and III). Two dermal alterations were evaluated by visual assessment and not by computer-assisted image analysis quantification. CONCLUSION: Our in vivo results demonstrate the benefits of daily photoprotection using a day cream containing appropriate broad-spectrum sunscreens, which prevent solar UV-induced skin damages. SN - 1097-6787 UR - https://www.unboundmedicine.com/medline/citation/18410803/The_benefit_of_daily_photoprotection_ DB - PRIME DP - Unbound Medicine ER -