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Peripheral cannabinoid CB1 receptors inhibit evoked responses of nociceptive neurones in vivo.
Eur J Pharmacol. 2008 May 31; 586(1-3):160-3.EJ

Abstract

We investigated the effect of peripheral administration of a selective cannabinoid CB1 receptor agonist arachidonyl-2-choroethylamide (ACEA), on evoked responses of primary afferents in vivo. Extracellular recordings were made from filaments of the saphenous nerve that responded to noxious mechanical stimulation of their receptive fields and effects of ACEA (30 and 50 microg/100 microl, i.a.) were studied. ACEA significantly inhibited evoked responses, effects that were blocked by co-administration of the cannabinoid CB1 receptor antagonist AM251 (30 microg/100 microl). These results demonstrate a cannabinoid CB1 receptor-mediated inhibition of primary afferent nociceptor excitability and provide further support for a peripheral site of action of cannabinoids.

Authors+Show Affiliations

Division of Animal Physiology and Institute of Neuroscience, University of Nottingham, Sutton Bonington Campus, Loughborough, Leicestershire, LE12 5RD, United Kingdom. sara.kelly@nottingham.ac.ukNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18410918

Citation

Kelly, Sara, and Lucy F. Donaldson. "Peripheral Cannabinoid CB1 Receptors Inhibit Evoked Responses of Nociceptive Neurones in Vivo." European Journal of Pharmacology, vol. 586, no. 1-3, 2008, pp. 160-3.
Kelly S, Donaldson LF. Peripheral cannabinoid CB1 receptors inhibit evoked responses of nociceptive neurones in vivo. Eur J Pharmacol. 2008;586(1-3):160-3.
Kelly, S., & Donaldson, L. F. (2008). Peripheral cannabinoid CB1 receptors inhibit evoked responses of nociceptive neurones in vivo. European Journal of Pharmacology, 586(1-3), 160-3. https://doi.org/10.1016/j.ejphar.2008.03.003
Kelly S, Donaldson LF. Peripheral Cannabinoid CB1 Receptors Inhibit Evoked Responses of Nociceptive Neurones in Vivo. Eur J Pharmacol. 2008 May 31;586(1-3):160-3. PubMed PMID: 18410918.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Peripheral cannabinoid CB1 receptors inhibit evoked responses of nociceptive neurones in vivo. AU - Kelly,Sara, AU - Donaldson,Lucy F, Y1 - 2008/03/13/ PY - 2007/11/23/received PY - 2008/02/20/revised PY - 2008/03/03/accepted PY - 2008/4/16/pubmed PY - 2008/9/3/medline PY - 2008/4/16/entrez SP - 160 EP - 3 JF - European journal of pharmacology JO - Eur J Pharmacol VL - 586 IS - 1-3 N2 - We investigated the effect of peripheral administration of a selective cannabinoid CB1 receptor agonist arachidonyl-2-choroethylamide (ACEA), on evoked responses of primary afferents in vivo. Extracellular recordings were made from filaments of the saphenous nerve that responded to noxious mechanical stimulation of their receptive fields and effects of ACEA (30 and 50 microg/100 microl, i.a.) were studied. ACEA significantly inhibited evoked responses, effects that were blocked by co-administration of the cannabinoid CB1 receptor antagonist AM251 (30 microg/100 microl). These results demonstrate a cannabinoid CB1 receptor-mediated inhibition of primary afferent nociceptor excitability and provide further support for a peripheral site of action of cannabinoids. SN - 0014-2999 UR - https://www.unboundmedicine.com/medline/citation/18410918/Peripheral_cannabinoid_CB1_receptors_inhibit_evoked_responses_of_nociceptive_neurones_in_vivo_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0014-2999(08)00271-9 DB - PRIME DP - Unbound Medicine ER -