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Cosmetic effectiveness of topically applied hydrolysed keratin peptides and lipids derived from wool.
Skin Res Technol. 2008 May; 14(2):243-8.SR

Abstract

BACKGROUND/PURPOSE

Skin moisturisation, elasticity, feel and appearance can all be improved through the topical application of protein hydrolysates. Recent studies suggest that supplementing intercellular lipids of the stratum corneum can enhance the functioning of the skin.

METHODS

In this study, a hydrolysed keratin peptide (molecular weight <1000 Da) was prepared from wool and tested on skin in two different formulations: an aqueous solution and an internal wool lipids (IWL) liposome suspension. In vivo long-term studies were performed to evaluate the water barrier function of the skin after topical application of different formulations. During the treatment period, hydration and elasticity were determined. A sorption-desorption test was also performed to assess the hygroscopic properties and water-holding capacity of the different treated skin sites.

RESULTS

Significant differences were found between the control and treated sites, with the treated areas showing an increase in hydration and elasticity as a result of keratin peptide application. Measurements also indicated that the keratin formulations reinforce the skin barrier integrity, improving its water-holding capacity.

CONCLUSION

A combination of the keratin peptide with the IWL showed beneficial effects, indicating that this combination is suitable for designing new cosmetics products.

Authors+Show Affiliations

Department of Surfactant Technology, Chemical and Environmental Research Institute of Barcelona, Barcelona, Spain. cbaesl@iiqab.csic.esNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18412569

Citation

Barba, C, et al. "Cosmetic Effectiveness of Topically Applied Hydrolysed Keratin Peptides and Lipids Derived From Wool." Skin Research and Technology : Official Journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI), vol. 14, no. 2, 2008, pp. 243-8.
Barba C, Méndez S, Roddick-Lanzilotta A, et al. Cosmetic effectiveness of topically applied hydrolysed keratin peptides and lipids derived from wool. Skin Res Technol. 2008;14(2):243-8.
Barba, C., Méndez, S., Roddick-Lanzilotta, A., Kelly, R., Parra, J. L., & Coderch, L. (2008). Cosmetic effectiveness of topically applied hydrolysed keratin peptides and lipids derived from wool. Skin Research and Technology : Official Journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI), 14(2), 243-8. https://doi.org/10.1111/j.1600-0846.2007.00280.x
Barba C, et al. Cosmetic Effectiveness of Topically Applied Hydrolysed Keratin Peptides and Lipids Derived From Wool. Skin Res Technol. 2008;14(2):243-8. PubMed PMID: 18412569.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Cosmetic effectiveness of topically applied hydrolysed keratin peptides and lipids derived from wool. AU - Barba,C, AU - Méndez,S, AU - Roddick-Lanzilotta,A, AU - Kelly,R, AU - Parra,J L, AU - Coderch,L, PY - 2008/4/17/pubmed PY - 2008/5/7/medline PY - 2008/4/17/entrez SP - 243 EP - 8 JF - Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI) JO - Skin Res Technol VL - 14 IS - 2 N2 - BACKGROUND/PURPOSE: Skin moisturisation, elasticity, feel and appearance can all be improved through the topical application of protein hydrolysates. Recent studies suggest that supplementing intercellular lipids of the stratum corneum can enhance the functioning of the skin. METHODS: In this study, a hydrolysed keratin peptide (molecular weight <1000 Da) was prepared from wool and tested on skin in two different formulations: an aqueous solution and an internal wool lipids (IWL) liposome suspension. In vivo long-term studies were performed to evaluate the water barrier function of the skin after topical application of different formulations. During the treatment period, hydration and elasticity were determined. A sorption-desorption test was also performed to assess the hygroscopic properties and water-holding capacity of the different treated skin sites. RESULTS: Significant differences were found between the control and treated sites, with the treated areas showing an increase in hydration and elasticity as a result of keratin peptide application. Measurements also indicated that the keratin formulations reinforce the skin barrier integrity, improving its water-holding capacity. CONCLUSION: A combination of the keratin peptide with the IWL showed beneficial effects, indicating that this combination is suitable for designing new cosmetics products. SN - 1600-0846 UR - https://www.unboundmedicine.com/medline/citation/18412569/Cosmetic_effectiveness_of_topically_applied_hydrolysed_keratin_peptides_and_lipids_derived_from_wool_ L2 - https://doi.org/10.1111/j.1600-0846.2007.00280.x DB - PRIME DP - Unbound Medicine ER -