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Advanced glycation index and its association with severity of diabetic retinopathy in type 2 diabetic subjects.
J Diabetes Complications. 2008 Jul-Aug; 22(4):261-6.JD

Abstract

BACKGROUND

This study investigates the association of advanced glycation index (AGI), a simple assay to detect advanced glycation endproducts (AGEs) in serum, with severity of diabetic retinopathy (DR) in type 2 diabetic subjects.

METHODS

The study included 188 type 2 diabetic subjects without DR, 153 subjects with nonproliferative DR, 41 subjects with proliferative DR, and 188 control participants. Serum levels of AGEs were monitored with a spectrofluorimeter by recording Maillard-specific fluorescence.

RESULTS

AGI values increased with severity of DR (analysis of variance, P<.0001). Among diabetic subjects, AGI (mean+/-S.E.) was higher among subjects with nonproliferative diabetic retinopathy (NPDR; 6.7+/-0.1 U) and proliferative diabetic retinopathy (PDR; 9.1+/-0.3 U) than among subjects without DR (P<.0001). By arranging the levels of serum AGI in quartiles, the proportion of PDR subjects increased with increasing AGI values, with maximum subjects in the last quartile (trend chi(2)=60.239, P<.0001). AGI was associated with NPDR even after adjusting for age, gender, duration of diabetes, and glycated hemoglobin [odds ratio (OR)=1.33; 95% confidence interval (95% CI)=1.12-1.57; P=.001]. Similarly, AGI showed a significant association with PDR even after adjusting for various risk factors (OR=2.47; 95% CI=1.75-3.47; P<.0001). Receiver-operating-characteristics curve analysis revealed that the threshold level of 8.07 U had a 78% sensitivity, an 83.6% specificity, and an 86.1% accuracy for detecting PDR.

CONCLUSION

AGI showed a significant association with the severity of DR and, hence, could be used as a prognostic tool to predict the development and progression of DR.

Authors+Show Affiliations

Madras Diabetes Research Foundation and Dr. Mohan's Diabetes Specialities Center, Gopalapuram, Chennai, India.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

18413194

Citation

Anitha, Balaji, et al. "Advanced Glycation Index and Its Association With Severity of Diabetic Retinopathy in Type 2 Diabetic Subjects." Journal of Diabetes and Its Complications, vol. 22, no. 4, 2008, pp. 261-6.
Anitha B, Sampathkumar R, Balasubramanyam M, et al. Advanced glycation index and its association with severity of diabetic retinopathy in type 2 diabetic subjects. J Diabetes Complicat. 2008;22(4):261-6.
Anitha, B., Sampathkumar, R., Balasubramanyam, M., & Rema, M. (2008). Advanced glycation index and its association with severity of diabetic retinopathy in type 2 diabetic subjects. Journal of Diabetes and Its Complications, 22(4), 261-6. https://doi.org/10.1016/j.jdiacomp.2007.05.005
Anitha B, et al. Advanced Glycation Index and Its Association With Severity of Diabetic Retinopathy in Type 2 Diabetic Subjects. J Diabetes Complicat. 2008 Jul-Aug;22(4):261-6. PubMed PMID: 18413194.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Advanced glycation index and its association with severity of diabetic retinopathy in type 2 diabetic subjects. AU - Anitha,Balaji, AU - Sampathkumar,Rangasamy, AU - Balasubramanyam,Muthuswamy, AU - Rema,Mohan, Y1 - 2008/04/16/ PY - 2006/10/28/received PY - 2007/04/26/revised PY - 2007/05/10/accepted PY - 2008/4/17/pubmed PY - 2008/8/7/medline PY - 2008/4/17/entrez SP - 261 EP - 6 JF - Journal of diabetes and its complications JO - J. Diabetes Complicat. VL - 22 IS - 4 N2 - BACKGROUND: This study investigates the association of advanced glycation index (AGI), a simple assay to detect advanced glycation endproducts (AGEs) in serum, with severity of diabetic retinopathy (DR) in type 2 diabetic subjects. METHODS: The study included 188 type 2 diabetic subjects without DR, 153 subjects with nonproliferative DR, 41 subjects with proliferative DR, and 188 control participants. Serum levels of AGEs were monitored with a spectrofluorimeter by recording Maillard-specific fluorescence. RESULTS: AGI values increased with severity of DR (analysis of variance, P<.0001). Among diabetic subjects, AGI (mean+/-S.E.) was higher among subjects with nonproliferative diabetic retinopathy (NPDR; 6.7+/-0.1 U) and proliferative diabetic retinopathy (PDR; 9.1+/-0.3 U) than among subjects without DR (P<.0001). By arranging the levels of serum AGI in quartiles, the proportion of PDR subjects increased with increasing AGI values, with maximum subjects in the last quartile (trend chi(2)=60.239, P<.0001). AGI was associated with NPDR even after adjusting for age, gender, duration of diabetes, and glycated hemoglobin [odds ratio (OR)=1.33; 95% confidence interval (95% CI)=1.12-1.57; P=.001]. Similarly, AGI showed a significant association with PDR even after adjusting for various risk factors (OR=2.47; 95% CI=1.75-3.47; P<.0001). Receiver-operating-characteristics curve analysis revealed that the threshold level of 8.07 U had a 78% sensitivity, an 83.6% specificity, and an 86.1% accuracy for detecting PDR. CONCLUSION: AGI showed a significant association with the severity of DR and, hence, could be used as a prognostic tool to predict the development and progression of DR. SN - 1873-460X UR - https://www.unboundmedicine.com/medline/citation/18413194/Advanced_glycation_index_and_its_association_with_severity_of_diabetic_retinopathy_in_type_2_diabetic_subjects_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1056-8727(07)00060-8 DB - PRIME DP - Unbound Medicine ER -