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Pituitary and ovarian response to acute stimulation with LH-RH in normal and anovulatory women.
Int J Fertil. 1977; 22(1):6-15.IJ

Abstract

The LH FSH estradiol and progesterone responses to acute stimulation with LH-RH were studied in 12 normal women with ovulatory cycles (4 in the initial follicular phase, 4 in the mid-follicular phase and 4 in the late follicular phase) and in two castrated women, two under hormonal contraception, two with ovarian amenorrhea, twelve with central amenorrhea of no detectable origin (6 with normal and 6 with low basal gonadotrophins), eleven anovulatory patients with pseudomenstruation, two with anorexia nervosa, and two with pituitary amenorrhea. Each woman received a rapid i.v. injection of 100 microgram synthetic LH-RH at 9:00 a.m. Serum levels of LH, FSH, estradiol and progesterone were determined by radioimmunoassay in samples collected before and 60, 120, 240 and 480 minutes after injection. The findings were : 1) A significant rise in estradiol and progesterone levels, in addition to LH and FSH elevation, in normal women; 2) A lack of ovarian steroid response in the castrated women and in ovarian amenorrheas, which suggests that the source of steroid response to stimulation is not extragonadal; 3) Significant differences in the responses of the four hormones to LH-RH in the women with central amenorrhea in comparison with the normal group with great variability of results; the steroid response in the presence of a positive LH response might correlate with the severity and/or prognosis of the disorder, a point deserving further study; 4) In anovulatory women with pseudomenstruation, LH responses for the most part normal, and particularly, progesterone responses.

Authors

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Pub Type(s)

Journal Article

Language

eng

PubMed ID

18416

Citation

Aparicio, N J., et al. "Pituitary and Ovarian Response to Acute Stimulation With LH-RH in Normal and Anovulatory Women." International Journal of Fertility, vol. 22, no. 1, 1977, pp. 6-15.
Aparicio NJ, Casas PR, Galimberti DM, et al. Pituitary and ovarian response to acute stimulation with LH-RH in normal and anovulatory women. Int J Fertil. 1977;22(1):6-15.
Aparicio, N. J., Casas, P. R., Galimberti, D. M., de Laborde, N. P., Badano, A., García, E. P., Meichi, H. R., Mirkin, A., Szejner, M., Jaitt, A., Margulies, M., & Rosner, J. M. (1977). Pituitary and ovarian response to acute stimulation with LH-RH in normal and anovulatory women. International Journal of Fertility, 22(1), 6-15.
Aparicio NJ, et al. Pituitary and Ovarian Response to Acute Stimulation With LH-RH in Normal and Anovulatory Women. Int J Fertil. 1977;22(1):6-15. PubMed PMID: 18416.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Pituitary and ovarian response to acute stimulation with LH-RH in normal and anovulatory women. AU - Aparicio,N J, AU - Casas,P R, AU - Galimberti,D M, AU - de Laborde,N P, AU - Badano,A, AU - García,E P, AU - Meichi,H R, AU - Mirkin,A, AU - Szejner,M, AU - Jaitt,A, AU - Margulies,M, AU - Rosner,J M, PY - 1977/1/1/pubmed PY - 1977/1/1/medline PY - 1977/1/1/entrez KW - Amenorrhea KW - Anovulation KW - Biology KW - Castration KW - Clinical Research KW - Comparative Studies KW - Diseases KW - Endocrine System KW - Estradiol--analysis KW - Estrogens KW - Follicle Stimulating Hormone--analysis KW - Genitalia KW - Genitalia, Female KW - Gonadotropins KW - Gonadotropins, Pituitary KW - Hematological Effects KW - Hormones KW - Luteinizing Hormone--analysis KW - Menstruation Disorders KW - Ovarian Effects KW - Ovary KW - Physiology KW - Pituitary Gland KW - Pituitary Hormone Releasing Hormones--administraction and dosage KW - Pituitary Hormone Releasing Hormones--side effects KW - Pituitary Hormone Releasing Hormones--therapeutic use KW - Progestational Hormones KW - Progesterone--analysis KW - Research Methodology KW - Studies KW - Surgery KW - Treatment KW - Urogenital Surgery KW - Urogenital System SP - 6 EP - 15 JF - International journal of fertility JO - Int J Fertil VL - 22 IS - 1 N2 - The LH FSH estradiol and progesterone responses to acute stimulation with LH-RH were studied in 12 normal women with ovulatory cycles (4 in the initial follicular phase, 4 in the mid-follicular phase and 4 in the late follicular phase) and in two castrated women, two under hormonal contraception, two with ovarian amenorrhea, twelve with central amenorrhea of no detectable origin (6 with normal and 6 with low basal gonadotrophins), eleven anovulatory patients with pseudomenstruation, two with anorexia nervosa, and two with pituitary amenorrhea. Each woman received a rapid i.v. injection of 100 microgram synthetic LH-RH at 9:00 a.m. Serum levels of LH, FSH, estradiol and progesterone were determined by radioimmunoassay in samples collected before and 60, 120, 240 and 480 minutes after injection. The findings were : 1) A significant rise in estradiol and progesterone levels, in addition to LH and FSH elevation, in normal women; 2) A lack of ovarian steroid response in the castrated women and in ovarian amenorrheas, which suggests that the source of steroid response to stimulation is not extragonadal; 3) Significant differences in the responses of the four hormones to LH-RH in the women with central amenorrhea in comparison with the normal group with great variability of results; the steroid response in the presence of a positive LH response might correlate with the severity and/or prognosis of the disorder, a point deserving further study; 4) In anovulatory women with pseudomenstruation, LH responses for the most part normal, and particularly, progesterone responses. SN - 0020-725X UR - https://www.unboundmedicine.com/medline/citation/18416/Pituitary_and_ovarian_response_to_acute_stimulation_with_LH_RH_in_normal_and_anovulatory_women_ DB - PRIME DP - Unbound Medicine ER -