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Effect of variable long-term maternal feed allowance on the development of the ovine placenta and fetus.
Placenta. 2008 Jun; 29(6):539-48.P

Abstract

Maternal feed allowance during pregnancy can affect the development of the ovine placenta and fetus. The impact of variations in feed allowance prior to as well as throughout pregnancy has received less attention. Ewes were offered 0.6 (R), 1.2 (C) or 1.8 (AL) maintenance requirements from 89 days before conception until day 133 of pregnancy. Ewes were euthanised on days 50, 92 and 133 of pregnancy. Ewe live weight and body condition score, maternal and fetal metabolic and hormonal profiles, fetal body dimensions and organ weights, and the number, weight and morphology of placentomes were measured. Maternal live weight and condition score were lower in R compared to AL ewes at all stages of pregnancy (P<0.05). Plasma glucose and albumin concentrations of R ewes were significantly reduced (P<0.05) at mid and late gestation, respectively. Placental components were generally unresponsive to long term variations in maternal feed allowance. However, placental weight was significantly (P<0.05) correlated with fetal weight at days 50 (r=0.59) and 133 (r=0.69) of gestation. By late gestation growth-retarded singleton fetuses from R ewes were 19% lighter (P<0.05), with reduced abdominal (9%) and thoracic (10%) girths (P<0.05) but of similar crown-rump length compared with fetuses from AL ewes. These differences were associated with significantly reduced IGF-I concentrations in fetal plasma (P<0.05). In conclusion, maternal, placental and fetal adaptations to long established planes of variable maternal feed allowance were able to maintain fetal growth during early and mid-pregnancy while fetal growth restriction, associated with reduced fetal IGF-I levels, became apparent in late pregnancy.

Authors+Show Affiliations

South Australian Research and Development Institute, Turretfield Research Centre, Rosedale, SA 5350, Australia.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18417210

Citation

Quigley, S P., et al. "Effect of Variable Long-term Maternal Feed Allowance On the Development of the Ovine Placenta and Fetus." Placenta, vol. 29, no. 6, 2008, pp. 539-48.
Quigley SP, Kleemann DO, Walker SK, et al. Effect of variable long-term maternal feed allowance on the development of the ovine placenta and fetus. Placenta. 2008;29(6):539-48.
Quigley, S. P., Kleemann, D. O., Walker, S. K., Speck, P. A., Rudiger, S. R., Nattrass, G. S., DeBlasio, M. J., & Owens, J. A. (2008). Effect of variable long-term maternal feed allowance on the development of the ovine placenta and fetus. Placenta, 29(6), 539-48. https://doi.org/10.1016/j.placenta.2008.02.014
Quigley SP, et al. Effect of Variable Long-term Maternal Feed Allowance On the Development of the Ovine Placenta and Fetus. Placenta. 2008;29(6):539-48. PubMed PMID: 18417210.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of variable long-term maternal feed allowance on the development of the ovine placenta and fetus. AU - Quigley,S P, AU - Kleemann,D O, AU - Walker,S K, AU - Speck,P A, AU - Rudiger,S R, AU - Nattrass,G S, AU - DeBlasio,M J, AU - Owens,J A, Y1 - 2008/04/15/ PY - 2007/09/05/received PY - 2008/02/26/revised PY - 2008/02/27/accepted PY - 2008/4/18/pubmed PY - 2008/8/30/medline PY - 2008/4/18/entrez SP - 539 EP - 48 JF - Placenta JO - Placenta VL - 29 IS - 6 N2 - Maternal feed allowance during pregnancy can affect the development of the ovine placenta and fetus. The impact of variations in feed allowance prior to as well as throughout pregnancy has received less attention. Ewes were offered 0.6 (R), 1.2 (C) or 1.8 (AL) maintenance requirements from 89 days before conception until day 133 of pregnancy. Ewes were euthanised on days 50, 92 and 133 of pregnancy. Ewe live weight and body condition score, maternal and fetal metabolic and hormonal profiles, fetal body dimensions and organ weights, and the number, weight and morphology of placentomes were measured. Maternal live weight and condition score were lower in R compared to AL ewes at all stages of pregnancy (P<0.05). Plasma glucose and albumin concentrations of R ewes were significantly reduced (P<0.05) at mid and late gestation, respectively. Placental components were generally unresponsive to long term variations in maternal feed allowance. However, placental weight was significantly (P<0.05) correlated with fetal weight at days 50 (r=0.59) and 133 (r=0.69) of gestation. By late gestation growth-retarded singleton fetuses from R ewes were 19% lighter (P<0.05), with reduced abdominal (9%) and thoracic (10%) girths (P<0.05) but of similar crown-rump length compared with fetuses from AL ewes. These differences were associated with significantly reduced IGF-I concentrations in fetal plasma (P<0.05). In conclusion, maternal, placental and fetal adaptations to long established planes of variable maternal feed allowance were able to maintain fetal growth during early and mid-pregnancy while fetal growth restriction, associated with reduced fetal IGF-I levels, became apparent in late pregnancy. SN - 0143-4004 UR - https://www.unboundmedicine.com/medline/citation/18417210/Effect_of_variable_long_term_maternal_feed_allowance_on_the_development_of_the_ovine_placenta_and_fetus_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0143-4004(08)00088-X DB - PRIME DP - Unbound Medicine ER -