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Effect of vagal nerve stimulation on systemic inflammation and cardiac autonomic function in patients with refractory epilepsy.
Neuroimmunomodulation. 2007; 14(6):331-6.N

Abstract

OBJECTIVE

Recent data suggest that vagus nerve stimulation (VNS) can inhibit cytokine release by inflammatory cells. Accordingly, an association between impaired cardiac parasympathetic function, as assessed by heart rate variability (HRV), and increased markers of inflammation has recently been reported. In this study we assessed the effect of direct left VNS on inflammatory markers and HRV in patients with refractory epilepsy.

METHODS

A 24-hour electrocardiogram Holter recording was performed both at baseline and after 3 months of left VNS in 8 patients (age 32 +/- 24 years, 2 men) who underwent implantation of a VNS device because of refractory epilepsy. Tumor necrosis factor-alpha, interleukin-6 and C-reactive protein serum levels were measured, as markers of inflammation, at the same times.

RESULTS

No significant changes were found after 3 months of left VNS, compared to baseline, both for HRV variables and inflammatory markers. Also, no consistent correlation could be demonstrated between HRV parameters and inflammatory markers in these patients.

CONCLUSIONS

Our data in epileptic patients without cardiovascular disease failed to show a significant effect of left VNS on cardiac autonomic function and on systemic inflammation at short-term follow-up.

Authors+Show Affiliations

Istituto di Cardiologia, Università Cattolica del Sacro Cuore, Roma, Italia.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

18418007

Citation

Barone, Lucy, et al. "Effect of Vagal Nerve Stimulation On Systemic Inflammation and Cardiac Autonomic Function in Patients With Refractory Epilepsy." Neuroimmunomodulation, vol. 14, no. 6, 2007, pp. 331-6.
Barone L, Colicchio G, Policicchio D, et al. Effect of vagal nerve stimulation on systemic inflammation and cardiac autonomic function in patients with refractory epilepsy. Neuroimmunomodulation. 2007;14(6):331-6.
Barone, L., Colicchio, G., Policicchio, D., Di Clemente, F., Di Monaco, A., Meglio, M., Lanza, G. A., & Crea, F. (2007). Effect of vagal nerve stimulation on systemic inflammation and cardiac autonomic function in patients with refractory epilepsy. Neuroimmunomodulation, 14(6), 331-6. https://doi.org/10.1159/000127360
Barone L, et al. Effect of Vagal Nerve Stimulation On Systemic Inflammation and Cardiac Autonomic Function in Patients With Refractory Epilepsy. Neuroimmunomodulation. 2007;14(6):331-6. PubMed PMID: 18418007.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of vagal nerve stimulation on systemic inflammation and cardiac autonomic function in patients with refractory epilepsy. AU - Barone,Lucy, AU - Colicchio,Gabriella, AU - Policicchio,Domenico, AU - Di Clemente,Francesca, AU - Di Monaco,Antonio, AU - Meglio,Mario, AU - Lanza,Gaetano A, AU - Crea,Filippo, Y1 - 2008/04/16/ PY - 2007/12/05/received PY - 2008/02/08/accepted PY - 2008/4/18/pubmed PY - 2008/7/23/medline PY - 2008/4/18/entrez SP - 331 EP - 6 JF - Neuroimmunomodulation JO - Neuroimmunomodulation VL - 14 IS - 6 N2 - OBJECTIVE: Recent data suggest that vagus nerve stimulation (VNS) can inhibit cytokine release by inflammatory cells. Accordingly, an association between impaired cardiac parasympathetic function, as assessed by heart rate variability (HRV), and increased markers of inflammation has recently been reported. In this study we assessed the effect of direct left VNS on inflammatory markers and HRV in patients with refractory epilepsy. METHODS: A 24-hour electrocardiogram Holter recording was performed both at baseline and after 3 months of left VNS in 8 patients (age 32 +/- 24 years, 2 men) who underwent implantation of a VNS device because of refractory epilepsy. Tumor necrosis factor-alpha, interleukin-6 and C-reactive protein serum levels were measured, as markers of inflammation, at the same times. RESULTS: No significant changes were found after 3 months of left VNS, compared to baseline, both for HRV variables and inflammatory markers. Also, no consistent correlation could be demonstrated between HRV parameters and inflammatory markers in these patients. CONCLUSIONS: Our data in epileptic patients without cardiovascular disease failed to show a significant effect of left VNS on cardiac autonomic function and on systemic inflammation at short-term follow-up. SN - 1423-0216 UR - https://www.unboundmedicine.com/medline/citation/18418007/Effect_of_vagal_nerve_stimulation_on_systemic_inflammation_and_cardiac_autonomic_function_in_patients_with_refractory_epilepsy_ DB - PRIME DP - Unbound Medicine ER -