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Lipoprotein(a) is associated with coronary heart disease independent of metabolic syndrome.
Coron Artery Dis. 2008 May; 19(3):125-31.CA

Abstract

AIM

To assess (i) the association between lipoprotein(a) [Lp(a)] with the likelihood of coronary heart disease and metabolic syndrome (MS) and (ii) its covariates in Turkish adults.

METHODS

Cross-sectional evaluation of 1309 adults, who had serum Lp(a) determinations by Behring nephelometry, and followed for a mean 1.0 year. MS was defined by ATPIII criteria modified for male abdominal obesity.

RESULTS

Mean age of the sample was 56.8+/-11.3 years. After adjustment for sex, age, and smoking status, log-transformed Lp(a) levels were associated significantly with coronary heart disease likelihood in both sexes combined [odds ratio: 1.53 (95% confidence interval: 1.06; 2.20)]. This association persisted after additional adjustment for MS [odds ratio: 1.57 (95% confidence interval: 1.09; 2.26)]. The Lp(a) mid-tertile (5-17 mg/dl), accompanied by significantly lower serum triglycerides than the two remaining tertiles, was inversely associated significantly with MS in either sex; in women, this association was independent of waist circumference. In a linear regression comprising seven variables, excepting total cholesterol, only gamma-glutamyltransferase in women (P=0.002) and waist circumference (P=0.057) in men were inverse covariates of modest magnitude of Lp(a).

CONCLUSION

Coronary heart disease likelihood, significantly associated with Lp(a) concentrations, is independent of MS and insulin resistance. Suggestive evidence was provided that intermediary Lp(a) concentrations, when accompanied by the presence of MS, could accelerate progression of vascular disease, especially in women.

Authors+Show Affiliations

Turkish Society of Cardiology, Istanbul, Turkey. alt_onat@yahoo.com.trNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18418227

Citation

Onat, Altan, et al. "Lipoprotein(a) Is Associated With Coronary Heart Disease Independent of Metabolic Syndrome." Coronary Artery Disease, vol. 19, no. 3, 2008, pp. 125-31.
Onat A, Hergenç G, Ozhan H, et al. Lipoprotein(a) is associated with coronary heart disease independent of metabolic syndrome. Coron Artery Dis. 2008;19(3):125-31.
Onat, A., Hergenç, G., Ozhan, H., Kaya, Z., Bulur, S., Ayhan, E., & Can, G. (2008). Lipoprotein(a) is associated with coronary heart disease independent of metabolic syndrome. Coronary Artery Disease, 19(3), 125-31. https://doi.org/10.1097/MCA.0b013e3282f399cf
Onat A, et al. Lipoprotein(a) Is Associated With Coronary Heart Disease Independent of Metabolic Syndrome. Coron Artery Dis. 2008;19(3):125-31. PubMed PMID: 18418227.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Lipoprotein(a) is associated with coronary heart disease independent of metabolic syndrome. AU - Onat,Altan, AU - Hergenç,Gülay, AU - Ozhan,Hakan, AU - Kaya,Zekeriya, AU - Bulur,Serkan, AU - Ayhan,Erkan, AU - Can,Günay, PY - 2008/4/18/pubmed PY - 2008/8/15/medline PY - 2008/4/18/entrez SP - 125 EP - 31 JF - Coronary artery disease JO - Coron Artery Dis VL - 19 IS - 3 N2 - AIM: To assess (i) the association between lipoprotein(a) [Lp(a)] with the likelihood of coronary heart disease and metabolic syndrome (MS) and (ii) its covariates in Turkish adults. METHODS: Cross-sectional evaluation of 1309 adults, who had serum Lp(a) determinations by Behring nephelometry, and followed for a mean 1.0 year. MS was defined by ATPIII criteria modified for male abdominal obesity. RESULTS: Mean age of the sample was 56.8+/-11.3 years. After adjustment for sex, age, and smoking status, log-transformed Lp(a) levels were associated significantly with coronary heart disease likelihood in both sexes combined [odds ratio: 1.53 (95% confidence interval: 1.06; 2.20)]. This association persisted after additional adjustment for MS [odds ratio: 1.57 (95% confidence interval: 1.09; 2.26)]. The Lp(a) mid-tertile (5-17 mg/dl), accompanied by significantly lower serum triglycerides than the two remaining tertiles, was inversely associated significantly with MS in either sex; in women, this association was independent of waist circumference. In a linear regression comprising seven variables, excepting total cholesterol, only gamma-glutamyltransferase in women (P=0.002) and waist circumference (P=0.057) in men were inverse covariates of modest magnitude of Lp(a). CONCLUSION: Coronary heart disease likelihood, significantly associated with Lp(a) concentrations, is independent of MS and insulin resistance. Suggestive evidence was provided that intermediary Lp(a) concentrations, when accompanied by the presence of MS, could accelerate progression of vascular disease, especially in women. SN - 0954-6928 UR - https://www.unboundmedicine.com/medline/citation/18418227/Lipoprotein_a__is_associated_with_coronary_heart_disease_independent_of_metabolic_syndrome_ L2 - https://doi.org/10.1097/MCA.0b013e3282f399cf DB - PRIME DP - Unbound Medicine ER -