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Lipid and lipoprotein profile in women with polycystic ovary syndrome.
Can J Physiol Pharmacol. 2008 Apr; 86(4):199-204.CJ

Abstract

Polycystic ovary syndrome (PCOS) is a common endocrine disorder characterized by obesity-related risk factors for cardiovascular disease. The objective of our study was to determine values of key lipid and lipoprotein fractions in PCOS, and their possible relation to insulin resistance. A total of 75 women with PCOS (aged 23.1 +/- 5.1 years, BMI 24.9 +/- 4.7 kg/m(2)), and 56 age- and BMI-matched controls were investigated. In all subjects, basal glucose, cholesterol (total, HDL, and LDL), oxidized LDL (OxLDL), triglycerides, apolipoprotein (apo)A1, apoB, and apoE, nonesterified fatty acids, insulin, testosterone, sex hormone-binding globulin, homeostasis model assessment (HOMA) index, and free androgen index were determined in the follicular phase of the cycle. PCOS patients compared with controls had increased indices of insulin resistance, basal insulin (p < 0.001), and HOMA index (p < 0.001), and worsened insulin resistance-related dyslipidemia with decreased HDL cholesterol (p < 0.01), elevated triglycerides (p = 0.010), and pronounced LDL oxidation (p < 0.001). In conclusion, characteristic dyslipidemia of insulin resistance and unfavorable proatherogenic lipoprotein ratios were present only in women with PCOS and not in controls. Elevated OxLDL and the relation of apoE and nonesterified fatty acids with insulin resistance suggest that women with PCOS are at increased risk for premature atherosclerosis.

Authors+Show Affiliations

Institute of Endocrinology, Diabetes and Metabolic Diseases, Clinical Center of Serbia, Dr Subotića 13, Belgrade 11000, Serbia. macut@EUnet.rsNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18418429

Citation

Macut, Djuro, et al. "Lipid and Lipoprotein Profile in Women With Polycystic Ovary Syndrome." Canadian Journal of Physiology and Pharmacology, vol. 86, no. 4, 2008, pp. 199-204.
Macut D, Panidis D, Glisić B, et al. Lipid and lipoprotein profile in women with polycystic ovary syndrome. Can J Physiol Pharmacol. 2008;86(4):199-204.
Macut, D., Panidis, D., Glisić, B., Spanos, N., Petakov, M., Bjekić, J., Stanojlović, O., Rousso, D., Kourtis, A., Bozić, I., & Damjanović, S. (2008). Lipid and lipoprotein profile in women with polycystic ovary syndrome. Canadian Journal of Physiology and Pharmacology, 86(4), 199-204. https://doi.org/10.1139/Y08-014
Macut D, et al. Lipid and Lipoprotein Profile in Women With Polycystic Ovary Syndrome. Can J Physiol Pharmacol. 2008;86(4):199-204. PubMed PMID: 18418429.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Lipid and lipoprotein profile in women with polycystic ovary syndrome. AU - Macut,Djuro, AU - Panidis,Dimitrios, AU - Glisić,Biljana, AU - Spanos,Nikolaos, AU - Petakov,Milan, AU - Bjekić,Jelica, AU - Stanojlović,Olivera, AU - Rousso,David, AU - Kourtis,Anargyros, AU - Bozić,Ivana, AU - Damjanović,Svetozar, PY - 2008/4/18/pubmed PY - 2008/7/3/medline PY - 2008/4/18/entrez SP - 199 EP - 204 JF - Canadian journal of physiology and pharmacology JO - Can. J. Physiol. Pharmacol. VL - 86 IS - 4 N2 - Polycystic ovary syndrome (PCOS) is a common endocrine disorder characterized by obesity-related risk factors for cardiovascular disease. The objective of our study was to determine values of key lipid and lipoprotein fractions in PCOS, and their possible relation to insulin resistance. A total of 75 women with PCOS (aged 23.1 +/- 5.1 years, BMI 24.9 +/- 4.7 kg/m(2)), and 56 age- and BMI-matched controls were investigated. In all subjects, basal glucose, cholesterol (total, HDL, and LDL), oxidized LDL (OxLDL), triglycerides, apolipoprotein (apo)A1, apoB, and apoE, nonesterified fatty acids, insulin, testosterone, sex hormone-binding globulin, homeostasis model assessment (HOMA) index, and free androgen index were determined in the follicular phase of the cycle. PCOS patients compared with controls had increased indices of insulin resistance, basal insulin (p < 0.001), and HOMA index (p < 0.001), and worsened insulin resistance-related dyslipidemia with decreased HDL cholesterol (p < 0.01), elevated triglycerides (p = 0.010), and pronounced LDL oxidation (p < 0.001). In conclusion, characteristic dyslipidemia of insulin resistance and unfavorable proatherogenic lipoprotein ratios were present only in women with PCOS and not in controls. Elevated OxLDL and the relation of apoE and nonesterified fatty acids with insulin resistance suggest that women with PCOS are at increased risk for premature atherosclerosis. SN - 0008-4212 UR - https://www.unboundmedicine.com/medline/citation/18418429/Lipid_and_lipoprotein_profile_in_women_with_polycystic_ovary_syndrome_ L2 - http://www.nrcresearchpress.com/doi/full/10.1139/Y08-014?url_ver=Z39.88-2003&amp;rfr_id=ori:rid:crossref.org&amp;rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -