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Cigarette smoking is an independent predictor of nonadherence in HIV-infected individuals receiving highly active antiretroviral therapy.
Nicotine Tob Res. 2008 Apr; 10(4):731-6.NT

Abstract

Current treatment guidelines for the management of HIV-infected individuals emphasize the importance of excellent adherence to antiretroviral medications. We conducted a prospective 24-week study of adherence to lopinavir/ritonavir in a group of 64 subjects using the Medication Event Monitoring System (MEMS). A range of demographic and clinical information, including cigarette smoking status, was collected from each participant. The overall mean adherence rate of the study cohort was 72.8% (SD = 22.2%). Current smokers took 63.5% (SD = 22.1) of prescribed doses, compared with 84.8% (SD = 15.8%) in nonsmokers (p<.001). We found no difference in adherence rates between ex-smokers and subjects who had never smoked. In a multiple linear regression model, factors independently associated with lower adherence rates included current smoking (p = .001), lower CD4+ lymphocyte count at enrollment (p = .04), and lower educational attainment (p = .04). Depression and history of illicit substance use were not associated with nonadherence. In our study cohort, current cigarette smoking was an important and significant marker of inferior adherence to antiretroviral medication.

Authors+Show Affiliations

AIDS Center and Division of Infectious Diseases, Montefiore Medical Center, Bronx, NY 10467, USA. jshuter@montefiore.orgNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.

Language

eng

PubMed ID

18418794

Citation

Shuter, Jonathan, and Steven L. Bernstein. "Cigarette Smoking Is an Independent Predictor of Nonadherence in HIV-infected Individuals Receiving Highly Active Antiretroviral Therapy." Nicotine & Tobacco Research : Official Journal of the Society for Research On Nicotine and Tobacco, vol. 10, no. 4, 2008, pp. 731-6.
Shuter J, Bernstein SL. Cigarette smoking is an independent predictor of nonadherence in HIV-infected individuals receiving highly active antiretroviral therapy. Nicotine Tob Res. 2008;10(4):731-6.
Shuter, J., & Bernstein, S. L. (2008). Cigarette smoking is an independent predictor of nonadherence in HIV-infected individuals receiving highly active antiretroviral therapy. Nicotine & Tobacco Research : Official Journal of the Society for Research On Nicotine and Tobacco, 10(4), 731-6. https://doi.org/10.1080/14622200801908190
Shuter J, Bernstein SL. Cigarette Smoking Is an Independent Predictor of Nonadherence in HIV-infected Individuals Receiving Highly Active Antiretroviral Therapy. Nicotine Tob Res. 2008;10(4):731-6. PubMed PMID: 18418794.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Cigarette smoking is an independent predictor of nonadherence in HIV-infected individuals receiving highly active antiretroviral therapy. AU - Shuter,Jonathan, AU - Bernstein,Steven L, PY - 2008/4/18/pubmed PY - 2008/8/6/medline PY - 2008/4/18/entrez SP - 731 EP - 6 JF - Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco JO - Nicotine Tob. Res. VL - 10 IS - 4 N2 - Current treatment guidelines for the management of HIV-infected individuals emphasize the importance of excellent adherence to antiretroviral medications. We conducted a prospective 24-week study of adherence to lopinavir/ritonavir in a group of 64 subjects using the Medication Event Monitoring System (MEMS). A range of demographic and clinical information, including cigarette smoking status, was collected from each participant. The overall mean adherence rate of the study cohort was 72.8% (SD = 22.2%). Current smokers took 63.5% (SD = 22.1) of prescribed doses, compared with 84.8% (SD = 15.8%) in nonsmokers (p<.001). We found no difference in adherence rates between ex-smokers and subjects who had never smoked. In a multiple linear regression model, factors independently associated with lower adherence rates included current smoking (p = .001), lower CD4+ lymphocyte count at enrollment (p = .04), and lower educational attainment (p = .04). Depression and history of illicit substance use were not associated with nonadherence. In our study cohort, current cigarette smoking was an important and significant marker of inferior adherence to antiretroviral medication. SN - 1462-2203 UR - https://www.unboundmedicine.com/medline/citation/18418794/Cigarette_smoking_is_an_independent_predictor_of_nonadherence_in_HIV_infected_individuals_receiving_highly_active_antiretroviral_therapy_ L2 - https://academic.oup.com/ntr/article-lookup/doi/10.1080/14622200801908190 DB - PRIME DP - Unbound Medicine ER -