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Reduced mother-to-child transmission of HIV associated with infant but not maternal GB virus C infection.
J Infect Dis. 2008 May 15; 197(10):1369-77.JI

Abstract

BACKGROUND

Prolonged coinfection with GB virus C (GBV-C) has been associated with improved survival in human immunodeficiency virus (HIV)-infected adults. We investigated whether maternal or infant GBV-C infection was associated with mother-to-child transmission (MTCT) of HIV-1 infection.

METHODS

The study population included 1364 HIV-infected pregnant women enrolled in 3 studies of MTCT of HIV in Bangkok, Thailand (the studies were conducted from 1992-1994, 1996-1997, and 1999-2004, respectively). We tested plasma collected from pregnant women at delivery for GBV-C RNA, GBV-C antibody, and GBV-C viral genotype. If GBV-C RNA was detected in the maternal samples, the 4- or 6-month infant sample was tested for GBV-C RNA. The rates of MTCT of HIV among GBV-C-infected women and infants were compared with the rates among women and infants without GBV-C infection.

RESULTS

The prevalence of GBV-C RNA in maternal samples was 19%. Of 245 women who were GBV-C RNA positive, 101 (41%) transmitted GBV-C to their infants. Of 101 infants who were GBV-C RNA positive, 2 (2%) were infected with HIV, compared with 162 (13%) of 1232 infants who were GBV-C RNA negative (odds ratio [OR] adjusted for study, 0.13 [95% confidence interval {CI}, 0.03-0.54]). This association remained after adjustment for maternal HIV viral load, receipt of antiretroviral prophylaxis, CD4(+) count, and other covariates. MTCT of HIV was not associated with the presence of GBV-C RNA (adjusted OR [aOR], 0.94 [95% CI, 0.62-1.42]) or GBV-C antibody (aOR, 0.90 [95% CI, 0.54-1.50]) in maternal samples.

CONCLUSIONS

Reduced MTCT of HIV was significantly associated with infant acquisition of GBV-C but not with maternal GBV-C infection. The mechanism for this association remains unknown.

Authors+Show Affiliations

Department of Public Health Sciences, University of Toronto,Toronto, Canada. supapol@cogeco.caNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

18419578

Citation

Supapol, Wendy Bhanich, et al. "Reduced Mother-to-child Transmission of HIV Associated With Infant but Not Maternal GB Virus C Infection." The Journal of Infectious Diseases, vol. 197, no. 10, 2008, pp. 1369-77.
Supapol WB, Remis RS, Raboud J, et al. Reduced mother-to-child transmission of HIV associated with infant but not maternal GB virus C infection. J Infect Dis. 2008;197(10):1369-77.
Supapol, W. B., Remis, R. S., Raboud, J., Millson, M., Tappero, J., Kaul, R., Kulkarni, P., McConnell, M. S., Mock, P. A., Culnane, M., McNicholl, J., Roongpisuthipong, A., Chotpitayasunondh, T., Shaffer, N., & Butera, S. (2008). Reduced mother-to-child transmission of HIV associated with infant but not maternal GB virus C infection. The Journal of Infectious Diseases, 197(10), 1369-77. https://doi.org/10.1086/587488
Supapol WB, et al. Reduced Mother-to-child Transmission of HIV Associated With Infant but Not Maternal GB Virus C Infection. J Infect Dis. 2008 May 15;197(10):1369-77. PubMed PMID: 18419578.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Reduced mother-to-child transmission of HIV associated with infant but not maternal GB virus C infection. AU - Supapol,Wendy Bhanich, AU - Remis,Robert S, AU - Raboud,Janet, AU - Millson,Margaret, AU - Tappero,Jordan, AU - Kaul,Rupert, AU - Kulkarni,Prasad, AU - McConnell,Michelle S, AU - Mock,Philip A, AU - Culnane,Mary, AU - McNicholl,Janet, AU - Roongpisuthipong,Anuvat, AU - Chotpitayasunondh,Tawee, AU - Shaffer,Nathan, AU - Butera,Salvatore, PY - 2008/4/19/pubmed PY - 2008/6/13/medline PY - 2008/4/19/entrez SP - 1369 EP - 77 JF - The Journal of infectious diseases JO - J Infect Dis VL - 197 IS - 10 N2 - BACKGROUND: Prolonged coinfection with GB virus C (GBV-C) has been associated with improved survival in human immunodeficiency virus (HIV)-infected adults. We investigated whether maternal or infant GBV-C infection was associated with mother-to-child transmission (MTCT) of HIV-1 infection. METHODS: The study population included 1364 HIV-infected pregnant women enrolled in 3 studies of MTCT of HIV in Bangkok, Thailand (the studies were conducted from 1992-1994, 1996-1997, and 1999-2004, respectively). We tested plasma collected from pregnant women at delivery for GBV-C RNA, GBV-C antibody, and GBV-C viral genotype. If GBV-C RNA was detected in the maternal samples, the 4- or 6-month infant sample was tested for GBV-C RNA. The rates of MTCT of HIV among GBV-C-infected women and infants were compared with the rates among women and infants without GBV-C infection. RESULTS: The prevalence of GBV-C RNA in maternal samples was 19%. Of 245 women who were GBV-C RNA positive, 101 (41%) transmitted GBV-C to their infants. Of 101 infants who were GBV-C RNA positive, 2 (2%) were infected with HIV, compared with 162 (13%) of 1232 infants who were GBV-C RNA negative (odds ratio [OR] adjusted for study, 0.13 [95% confidence interval {CI}, 0.03-0.54]). This association remained after adjustment for maternal HIV viral load, receipt of antiretroviral prophylaxis, CD4(+) count, and other covariates. MTCT of HIV was not associated with the presence of GBV-C RNA (adjusted OR [aOR], 0.94 [95% CI, 0.62-1.42]) or GBV-C antibody (aOR, 0.90 [95% CI, 0.54-1.50]) in maternal samples. CONCLUSIONS: Reduced MTCT of HIV was significantly associated with infant acquisition of GBV-C but not with maternal GBV-C infection. The mechanism for this association remains unknown. SN - 0022-1899 UR - https://www.unboundmedicine.com/medline/citation/18419578/Reduced_mother_to_child_transmission_of_HIV_associated_with_infant_but_not_maternal_GB_virus_C_infection_ L2 - https://academic.oup.com/jid/article-lookup/doi/10.1086/587488 DB - PRIME DP - Unbound Medicine ER -