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[Fluindione-induced acute generalised exanthematous pustulosis confirmed by patch testing].
Ann Dermatol Venereol. 2008 Apr; 135(4):295-8.AD

Abstract

BACKGROUND

Fluindione is an oral anticoagulant belonging to the vitamin K antagonist class. Although fluindione is very widely prescribed in France, few cases of cutaneous drug reactions have been reported. Below we describe a case of acute generalised exanthematous pustulosis due to fluindione as confirmed by patch-testing.

PATIENTS AND METHODS

A 70-year-old woman was hospitalised for diffuse erythematous and pustular rash 48hours after initiation of fluindione treatment for cardiac arrhythmia. A diagnosis of fluindione-induced acute generalised exanthematous pustulosis was made. After withdrawal of fluindione, the eruption cleared up within eight days. Warfarin was then used without skin reaction. Subsequent patch-tests were positive for fluindione.

DISCUSSION

These signs were consistent with fluindione-induced acute generalised exanthematous pustulosis. A causative role of fluindione is very likely in view of the rapid onset after initiation, improvement after withdrawal and positive patch tests. Skin patch-testing, which is easily performed, can be extremely helpful in determining a causal relationship with medication.

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Publisher Full Text (DOI)

Authors+Show Affiliations

Chtioui M
Service de dermatologie, hôpital Ambroise-Paré, Assistance publique-Hôpitaux de Paris, 9, avenue Charles-de-Gaulle, 92100 Boulogne-Billancourt, France.
Cousin-Testard F
No affiliation info available
Zimmermann U
No affiliation info available
Amar A
No affiliation info available
Saiag P
No affiliation info available
Mahé E
No affiliation info available

MeSH

AgedDrug EruptionsExanthemaFemaleHumansPatch TestsPhenindioneSkin Diseases, Vesiculobullous

Pub Type(s)

Case Reports
English Abstract
Journal Article

Language

fre

PubMed ID

18420077

Citation

Chtioui, M, et al. "[Fluindione-induced Acute Generalised Exanthematous Pustulosis Confirmed By Patch Testing]." Annales De Dermatologie Et De Venereologie, vol. 135, no. 4, 2008, pp. 295-8.
Chtioui M, Cousin-Testard F, Zimmermann U, et al. [Fluindione-induced acute generalised exanthematous pustulosis confirmed by patch testing]. Ann Dermatol Venereol. 2008;135(4):295-8.
Chtioui, M., Cousin-Testard, F., Zimmermann, U., Amar, A., Saiag, P., & Mahé, E. (2008). [Fluindione-induced acute generalised exanthematous pustulosis confirmed by patch testing]. Annales De Dermatologie Et De Venereologie, 135(4), 295-8. https://doi.org/10.1016/j.annder.2007.07.004
Chtioui M, et al. [Fluindione-induced Acute Generalised Exanthematous Pustulosis Confirmed By Patch Testing]. Ann Dermatol Venereol. 2008;135(4):295-8. PubMed PMID: 18420077.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Fluindione-induced acute generalised exanthematous pustulosis confirmed by patch testing]. AU - Chtioui,M, AU - Cousin-Testard,F, AU - Zimmermann,U, AU - Amar,A, AU - Saiag,P, AU - Mahé,E, Y1 - 2008/03/11/ PY - 2007/05/15/received PY - 2007/07/20/accepted PY - 2008/4/19/pubmed PY - 2008/8/30/medline PY - 2008/4/19/entrez SP - 295 EP - 8 JF - Annales de dermatologie et de venereologie JO - Ann Dermatol Venereol VL - 135 IS - 4 N2 - BACKGROUND: Fluindione is an oral anticoagulant belonging to the vitamin K antagonist class. Although fluindione is very widely prescribed in France, few cases of cutaneous drug reactions have been reported. Below we describe a case of acute generalised exanthematous pustulosis due to fluindione as confirmed by patch-testing. PATIENTS AND METHODS: A 70-year-old woman was hospitalised for diffuse erythematous and pustular rash 48hours after initiation of fluindione treatment for cardiac arrhythmia. A diagnosis of fluindione-induced acute generalised exanthematous pustulosis was made. After withdrawal of fluindione, the eruption cleared up within eight days. Warfarin was then used without skin reaction. Subsequent patch-tests were positive for fluindione. DISCUSSION: These signs were consistent with fluindione-induced acute generalised exanthematous pustulosis. A causative role of fluindione is very likely in view of the rapid onset after initiation, improvement after withdrawal and positive patch tests. Skin patch-testing, which is easily performed, can be extremely helpful in determining a causal relationship with medication. SN - 0151-9638 UR - https://www.unboundmedicine.com/medline/citation/18420077/[Fluindione_induced_acute_generalised_exanthematous_pustulosis_confirmed_by_patch_testing]_ DB - PRIME DP - Unbound Medicine ER -