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Influence of n-3 polyunsaturated fatty acids on soluble cellular adhesion molecules as biomarkers of cardiovascular risk in young healthy subjects.
Nutr Metab Cardiovasc Dis. 2008 Dec; 18(10):664-70.NM

Abstract

BACKGROUND AND AIM

Serum levels of soluble cellular adhesion molecules (CAMs) and blood lipid parameters have been used as markers of inflammatory processes associated with cardiovascular disease (CVD) events. The present study evaluated the effects of the intake of n-3 polyunsaturated fatty acids (PUFAs) in fish and fish oil within energy-restricted diets, on soluble intercellular adhesion molecule-1 (sICAM-1) and soluble vascular adhesion molecule-1 (sVCAM-1).

METHODS AND RESULTS

Two hundred and seventy-five healthy European subjects aged between 20 and 40 years, were randomized to one of four hypocaloric dietary groups: control (sunflower oil capsules, no seafood), lean fish (3 x 150 g portions of cod/week), fatty fish (3 x 150 g portions of salmon/week), fish oil ((docosahexaenoic acid (DHA)+eicosapentaenoic acid (EPA) capsules, no seafood)). Diets rich in lean fish significantly decreased ICAM-1 levels, around 5% from baseline to endpoint (p<0.05), and had no effect on VCAM-1 levels. No significant differences were observed in sICAM-1 levels after the intervention with fatty fish or fish oils. On the other hand, these two seafood based diets were responsible for a significant increase of VCAM-1 levels [fatty fish; 16.1% and fish oil; 21.9%] respectively (p<0.05).

CONCLUSIONS

CAMs as inflammatory biomarkers in young and healthy subjects are not conclusive for the evaluation of CVD risk. Hypocaloric fish diets had a different effect on CAMs, being lean fish responsible for the highest decrease in ICAM-1. On the other hand, VCAM-1 results allow speculation that a low dose of n-3 PUFA may be anti-inflammatory contrarily to a high dose which can have a pro-inflammatory effect. CAMs mechanism is complex and affected by multiple factors such as lifestyle, gender, and n-3 dose and source.

Authors+Show Affiliations

The National Research Institute of Agriculture and Fisheries Research, Lisbon, Portugal.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18420395

Citation

Paulo, Maria C., et al. "Influence of N-3 Polyunsaturated Fatty Acids On Soluble Cellular Adhesion Molecules as Biomarkers of Cardiovascular Risk in Young Healthy Subjects." Nutrition, Metabolism, and Cardiovascular Diseases : NMCD, vol. 18, no. 10, 2008, pp. 664-70.
Paulo MC, Andrade AM, Andrade ML, et al. Influence of n-3 polyunsaturated fatty acids on soluble cellular adhesion molecules as biomarkers of cardiovascular risk in young healthy subjects. Nutr Metab Cardiovasc Dis. 2008;18(10):664-70.
Paulo, M. C., Andrade, A. M., Andrade, M. L., Morais, M. G., Kiely, M., Parra, D., Martinéz, J. A., Thorsdottir, I., & Bandarra, N. M. (2008). Influence of n-3 polyunsaturated fatty acids on soluble cellular adhesion molecules as biomarkers of cardiovascular risk in young healthy subjects. Nutrition, Metabolism, and Cardiovascular Diseases : NMCD, 18(10), 664-70. https://doi.org/10.1016/j.numecd.2007.11.007
Paulo MC, et al. Influence of N-3 Polyunsaturated Fatty Acids On Soluble Cellular Adhesion Molecules as Biomarkers of Cardiovascular Risk in Young Healthy Subjects. Nutr Metab Cardiovasc Dis. 2008;18(10):664-70. PubMed PMID: 18420395.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Influence of n-3 polyunsaturated fatty acids on soluble cellular adhesion molecules as biomarkers of cardiovascular risk in young healthy subjects. AU - Paulo,Maria C, AU - Andrade,Ana M, AU - Andrade,Maria L, AU - Morais,Maria G, AU - Kiely,Mairead, AU - Parra,Dolores, AU - Martinéz,J Alfredo, AU - Thorsdottir,Inga, AU - Bandarra,Narcisa M, Y1 - 2008/04/16/ PY - 2007/05/23/received PY - 2007/10/03/revised PY - 2007/11/19/accepted PY - 2008/4/19/pubmed PY - 2009/1/28/medline PY - 2008/4/19/entrez SP - 664 EP - 70 JF - Nutrition, metabolism, and cardiovascular diseases : NMCD JO - Nutr Metab Cardiovasc Dis VL - 18 IS - 10 N2 - BACKGROUND AND AIM: Serum levels of soluble cellular adhesion molecules (CAMs) and blood lipid parameters have been used as markers of inflammatory processes associated with cardiovascular disease (CVD) events. The present study evaluated the effects of the intake of n-3 polyunsaturated fatty acids (PUFAs) in fish and fish oil within energy-restricted diets, on soluble intercellular adhesion molecule-1 (sICAM-1) and soluble vascular adhesion molecule-1 (sVCAM-1). METHODS AND RESULTS: Two hundred and seventy-five healthy European subjects aged between 20 and 40 years, were randomized to one of four hypocaloric dietary groups: control (sunflower oil capsules, no seafood), lean fish (3 x 150 g portions of cod/week), fatty fish (3 x 150 g portions of salmon/week), fish oil ((docosahexaenoic acid (DHA)+eicosapentaenoic acid (EPA) capsules, no seafood)). Diets rich in lean fish significantly decreased ICAM-1 levels, around 5% from baseline to endpoint (p<0.05), and had no effect on VCAM-1 levels. No significant differences were observed in sICAM-1 levels after the intervention with fatty fish or fish oils. On the other hand, these two seafood based diets were responsible for a significant increase of VCAM-1 levels [fatty fish; 16.1% and fish oil; 21.9%] respectively (p<0.05). CONCLUSIONS: CAMs as inflammatory biomarkers in young and healthy subjects are not conclusive for the evaluation of CVD risk. Hypocaloric fish diets had a different effect on CAMs, being lean fish responsible for the highest decrease in ICAM-1. On the other hand, VCAM-1 results allow speculation that a low dose of n-3 PUFA may be anti-inflammatory contrarily to a high dose which can have a pro-inflammatory effect. CAMs mechanism is complex and affected by multiple factors such as lifestyle, gender, and n-3 dose and source. SN - 1590-3729 UR - https://www.unboundmedicine.com/medline/citation/18420395/Influence_of_n_3_polyunsaturated_fatty_acids_on_soluble_cellular_adhesion_molecules_as_biomarkers_of_cardiovascular_risk_in_young_healthy_subjects_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0939-4753(07)00207-4 DB - PRIME DP - Unbound Medicine ER -