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Quantification analysis of human delta-globin gene. Mutation in 5'-splice junction sequence and delta-thalassemia.

Abstract

Nucleotide sequence of the exon-intron junction in human delta-globin pre-mRNA was analyzed by quantification method proposed previously. Using sample score of 9-nucleotide sequence in the consensus region of 5'-splice site, we examined strength of 5'-splice signal, which was found to play important role in splice site selection. To demonstrate the role, we studied two mutant genes of delta-thalassemia.

Authors+Show Affiliations

Department of Chemistry, Faculty of Science, Hokkaido University, Sapporo, Japan.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

1842064

Citation

Iida, Y. "Quantification Analysis of Human Delta-globin Gene. Mutation in 5'-splice Junction Sequence and Delta-thalassemia." Nucleic Acids Symposium Series, 1991, pp. 157-8.
Iida Y. Quantification analysis of human delta-globin gene. Mutation in 5'-splice junction sequence and delta-thalassemia. Nucleic Acids Symp Ser. 1991.
Iida, Y. (1991). Quantification analysis of human delta-globin gene. Mutation in 5'-splice junction sequence and delta-thalassemia. Nucleic Acids Symposium Series, (25), 157-8.
Iida Y. Quantification Analysis of Human Delta-globin Gene. Mutation in 5'-splice Junction Sequence and Delta-thalassemia. Nucleic Acids Symp Ser. 1991;(25)157-8. PubMed PMID: 1842064.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Quantification analysis of human delta-globin gene. Mutation in 5'-splice junction sequence and delta-thalassemia. A1 - Iida,Y, PY - 1991/1/1/pubmed PY - 1991/1/1/medline PY - 1991/1/1/entrez SP - 157 EP - 8 JF - Nucleic acids symposium series JO - Nucleic Acids Symp Ser IS - 25 N2 - Nucleotide sequence of the exon-intron junction in human delta-globin pre-mRNA was analyzed by quantification method proposed previously. Using sample score of 9-nucleotide sequence in the consensus region of 5'-splice site, we examined strength of 5'-splice signal, which was found to play important role in splice site selection. To demonstrate the role, we studied two mutant genes of delta-thalassemia. SN - 0261-3166 UR - https://www.unboundmedicine.com/medline/citation/1842064/Quantification_analysis_of_human_delta_globin_gene__Mutation_in_5'_splice_junction_sequence_and_delta_thalassemia_ L2 - http://www.diseaseinfosearch.org/result/7048 DB - PRIME DP - Unbound Medicine ER -
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