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Genomic characterizations of bat coronaviruses (1A, 1B and HKU8) and evidence for co-infections in Miniopterus bats.
J Gen Virol. 2008 May; 89(Pt 5):1282-1287.JG

Abstract

We previously reported the detection of bat coronaviruses (bat CoVs 1A, 1B, HKU7, HKU8 and bat-severe acute respiratory syndrome coronavirus) in Miniopterus spp. that cohabit a cave in Hong Kong. Here, we report the full genomic sequences of bat CoVs 1A, 1B and HKU8. Bat CoVs 1A and 1B, which are commonly found in the Miniopterus, are phylogenetically closely related. Using species-specific RT-PCR assays, bat CoVs 1A and 1B were confirmed to have distinct host specificities to Miniopterus magnater and Miniopterus pusillus, respectively. Interestingly, co-infections of bat CoVs 1B and HKU8 in M. pusillus are detected in seven of 38 virus-positive specimens collected from 2004 to 2006. These findings highlight that co-infections of some coronaviruses might be common events in nature. The biological basis for the host restriction of bat coronaviruses, however, is yet to be determined.

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Publisher Full Text (DOI)

Authors+Show Affiliations

Chu DKW
State Key Laboratory of Emerging Infectious Diseases, Department of Microbiology, The University of Hong Kong, Hong Kong SAR.
Peiris JSM
HKU-Pasteur Research Centre, Hong Kong SAR. State Key Laboratory of Emerging Infectious Diseases, Department of Microbiology, The University of Hong Kong, Hong Kong SAR.
Chen H
State Key Laboratory of Emerging Infectious Diseases, Department of Microbiology, The University of Hong Kong, Hong Kong SAR.
Guan Y
State Key Laboratory of Emerging Infectious Diseases, Department of Microbiology, The University of Hong Kong, Hong Kong SAR.
Poon LLM
State Key Laboratory of Emerging Infectious Diseases, Department of Microbiology, The University of Hong Kong, Hong Kong SAR.

MeSH

AnimalsChiropteraCoronavirusCoronavirus InfectionsGenome, ViralHong KongMolecular Sequence DataPhylogenySequence Analysis, DNASequence Homology

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18420807

Citation

Chu, D K W., et al. "Genomic Characterizations of Bat Coronaviruses (1A, 1B and HKU8) and Evidence for Co-infections in Miniopterus Bats." The Journal of General Virology, vol. 89, no. Pt 5, 2008, pp. 1282-1287.
Chu DKW, Peiris JSM, Chen H, et al. Genomic characterizations of bat coronaviruses (1A, 1B and HKU8) and evidence for co-infections in Miniopterus bats. J Gen Virol. 2008;89(Pt 5):1282-1287.
Chu, D. K. W., Peiris, J. S. M., Chen, H., Guan, Y., & Poon, L. L. M. (2008). Genomic characterizations of bat coronaviruses (1A, 1B and HKU8) and evidence for co-infections in Miniopterus bats. The Journal of General Virology, 89(Pt 5), 1282-1287. https://doi.org/10.1099/vir.0.83605-0
Chu DKW, et al. Genomic Characterizations of Bat Coronaviruses (1A, 1B and HKU8) and Evidence for Co-infections in Miniopterus Bats. J Gen Virol. 2008;89(Pt 5):1282-1287. PubMed PMID: 18420807.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Genomic characterizations of bat coronaviruses (1A, 1B and HKU8) and evidence for co-infections in Miniopterus bats. AU - Chu,D K W, AU - Peiris,J S M, AU - Chen,H, AU - Guan,Y, AU - Poon,L L M, PY - 2008/4/19/pubmed PY - 2008/6/6/medline PY - 2008/4/19/entrez SP - 1282 EP - 1287 JF - The Journal of general virology JO - J Gen Virol VL - 89 IS - Pt 5 N2 - We previously reported the detection of bat coronaviruses (bat CoVs 1A, 1B, HKU7, HKU8 and bat-severe acute respiratory syndrome coronavirus) in Miniopterus spp. that cohabit a cave in Hong Kong. Here, we report the full genomic sequences of bat CoVs 1A, 1B and HKU8. Bat CoVs 1A and 1B, which are commonly found in the Miniopterus, are phylogenetically closely related. Using species-specific RT-PCR assays, bat CoVs 1A and 1B were confirmed to have distinct host specificities to Miniopterus magnater and Miniopterus pusillus, respectively. Interestingly, co-infections of bat CoVs 1B and HKU8 in M. pusillus are detected in seven of 38 virus-positive specimens collected from 2004 to 2006. These findings highlight that co-infections of some coronaviruses might be common events in nature. The biological basis for the host restriction of bat coronaviruses, however, is yet to be determined. SN - 0022-1317 UR - https://www.unboundmedicine.com/medline/citation/18420807/Genomic_characterizations_of_bat_coronaviruses__1A_1B_and_HKU8__and_evidence_for_co_infections_in_Miniopterus_bats_ DB - PRIME DP - Unbound Medicine ER -