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Haloperidol versus ondansetron for prophylaxis of postoperative nausea and vomiting.
Anesth Analg. 2008 May; 106(5):1407-9, table of contents.A&A

Abstract

BACKGROUND

Haloperidol is effective for postoperative nausea and vomiting prophylaxis, but there are almost no data comparing it to 5-HT(3) antagonists.

METHODS

Two hundred forty-four adults were randomized to receive i.v. haloperidol 1 mg or ondansetron 4 mg, during general anesthesia. Nausea, vomiting, need for rescue, sedation, extrapyramidal effects, QTc intervals, and time to postanesthesia care unit discharge were evaluated with a third-party blind design.

RESULTS

There was no intergroup difference in any measure of efficacy or toxicity. Haloperidol and ondansetron subjects (78.2% and 76.8%) had complete response. Postoperatively, prolonged QTc occurred in 28.9% and 22.1% (N.S.).

CONCLUSIONS

In a mixed surgical population, the efficacy and toxicity of postoperative nausea and vomiting prophylaxis with haloperidol 1 mg was not significantly different from ondansetron 4 mg.

Authors+Show Affiliations

Department of Anesthesia and Critical Care, Massachusetts General Hospital, 55 Fruit St., Boston, MA 02114, USA. crosow@partners.orgNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18420852

Citation

Rosow, Carl E., et al. "Haloperidol Versus Ondansetron for Prophylaxis of Postoperative Nausea and Vomiting." Anesthesia and Analgesia, vol. 106, no. 5, 2008, 1407-9, table of contents.
Rosow CE, Haspel KL, Smith SE, et al. Haloperidol versus ondansetron for prophylaxis of postoperative nausea and vomiting. Anesth Analg. 2008;106(5):1407-9, table of contents.
Rosow, C. E., Haspel, K. L., Smith, S. E., Grecu, L., & Bittner, E. A. (2008). Haloperidol versus ondansetron for prophylaxis of postoperative nausea and vomiting. Anesthesia and Analgesia, 106(5), 1407-9, table of contents. https://doi.org/10.1213/ane.0b013e3181609022
Rosow CE, et al. Haloperidol Versus Ondansetron for Prophylaxis of Postoperative Nausea and Vomiting. Anesth Analg. 2008;106(5):1407-9, table of contents. PubMed PMID: 18420852.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Haloperidol versus ondansetron for prophylaxis of postoperative nausea and vomiting. AU - Rosow,Carl E, AU - Haspel,Kenneth L, AU - Smith,Sarah E, AU - Grecu,Loreta, AU - Bittner,Edward A, PY - 2008/4/19/pubmed PY - 2008/5/2/medline PY - 2008/4/19/entrez SP - 1407-9, table of contents JF - Anesthesia and analgesia JO - Anesth Analg VL - 106 IS - 5 N2 - BACKGROUND: Haloperidol is effective for postoperative nausea and vomiting prophylaxis, but there are almost no data comparing it to 5-HT(3) antagonists. METHODS: Two hundred forty-four adults were randomized to receive i.v. haloperidol 1 mg or ondansetron 4 mg, during general anesthesia. Nausea, vomiting, need for rescue, sedation, extrapyramidal effects, QTc intervals, and time to postanesthesia care unit discharge were evaluated with a third-party blind design. RESULTS: There was no intergroup difference in any measure of efficacy or toxicity. Haloperidol and ondansetron subjects (78.2% and 76.8%) had complete response. Postoperatively, prolonged QTc occurred in 28.9% and 22.1% (N.S.). CONCLUSIONS: In a mixed surgical population, the efficacy and toxicity of postoperative nausea and vomiting prophylaxis with haloperidol 1 mg was not significantly different from ondansetron 4 mg. SN - 1526-7598 UR - https://www.unboundmedicine.com/medline/citation/18420852/Haloperidol_versus_ondansetron_for_prophylaxis_of_postoperative_nausea_and_vomiting_ DB - PRIME DP - Unbound Medicine ER -