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Haloperidol plus ondansetron versus ondansetron alone for prophylaxis of postoperative nausea and vomiting.
Anesth Analg. 2008 May; 106(5):1410-3, table of contents.A&A

Abstract

INTRODUCTION

Haloperidol 1 mg and ondansetron 4 mg are equally safe and effective for postoperative nausea and vomiting prophylaxis. We compared the combination to ondansetron alone in a mixed surgical population.

METHODS

Two-hundred and sixty-eight adults undergoing general anesthesia received 4 mg ondansetron plus 1 mg haloperidol or saline in this randomized, double-blind protocol. Efficacy and safety data were obtained until 480 min after postanesthesia care unit entry.

RESULTS

The combination had more complete responders (76.2% vs 59.2%), less nausea, less rescue, and longer time to rescue. Sedation, time to postanesthesia care unit discharge, and QTc prolongation were not different. No subject had dystonia, akathisia, or serious dysrhythmias.

CONCLUSIONS

Postoperative nausea and vomiting prophylaxis with both drugs is significantly more effective and longer lasting than ondansetron alone. There is no detectable increase in side effects.

Authors+Show Affiliations

Department of Anesthesia and Critical Care, Massachusetts General Hospital, 55 Fruit St., Boston, MA 02114, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18420853

Citation

Grecu, Loreta, et al. "Haloperidol Plus Ondansetron Versus Ondansetron Alone for Prophylaxis of Postoperative Nausea and Vomiting." Anesthesia and Analgesia, vol. 106, no. 5, 2008, 1410-3, table of contents.
Grecu L, Bittner EA, Kher J, et al. Haloperidol plus ondansetron versus ondansetron alone for prophylaxis of postoperative nausea and vomiting. Anesth Analg. 2008;106(5):1410-3, table of contents.
Grecu, L., Bittner, E. A., Kher, J., Smith, S. E., & Rosow, C. E. (2008). Haloperidol plus ondansetron versus ondansetron alone for prophylaxis of postoperative nausea and vomiting. Anesthesia and Analgesia, 106(5), 1410-3, table of contents. https://doi.org/10.1213/ane.0b013e31816091f0
Grecu L, et al. Haloperidol Plus Ondansetron Versus Ondansetron Alone for Prophylaxis of Postoperative Nausea and Vomiting. Anesth Analg. 2008;106(5):1410-3, table of contents. PubMed PMID: 18420853.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Haloperidol plus ondansetron versus ondansetron alone for prophylaxis of postoperative nausea and vomiting. AU - Grecu,Loreta, AU - Bittner,Edward A, AU - Kher,Jay, AU - Smith,Sarah E, AU - Rosow,Carl E, PY - 2008/4/19/pubmed PY - 2008/5/2/medline PY - 2008/4/19/entrez SP - 1410-3, table of contents JF - Anesthesia and analgesia JO - Anesth Analg VL - 106 IS - 5 N2 - INTRODUCTION: Haloperidol 1 mg and ondansetron 4 mg are equally safe and effective for postoperative nausea and vomiting prophylaxis. We compared the combination to ondansetron alone in a mixed surgical population. METHODS: Two-hundred and sixty-eight adults undergoing general anesthesia received 4 mg ondansetron plus 1 mg haloperidol or saline in this randomized, double-blind protocol. Efficacy and safety data were obtained until 480 min after postanesthesia care unit entry. RESULTS: The combination had more complete responders (76.2% vs 59.2%), less nausea, less rescue, and longer time to rescue. Sedation, time to postanesthesia care unit discharge, and QTc prolongation were not different. No subject had dystonia, akathisia, or serious dysrhythmias. CONCLUSIONS: Postoperative nausea and vomiting prophylaxis with both drugs is significantly more effective and longer lasting than ondansetron alone. There is no detectable increase in side effects. SN - 1526-7598 UR - https://www.unboundmedicine.com/medline/citation/18420853/Haloperidol_plus_ondansetron_versus_ondansetron_alone_for_prophylaxis_of_postoperative_nausea_and_vomiting_ DB - PRIME DP - Unbound Medicine ER -