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[Effect of vitamin C and E on antioxidative enzyme, NOS activity and NO contents in hippocampus of rats with lead poisoning].
Zhejiang Da Xue Xue Bao Yi Xue Ban. 2008 Mar; 37(2):189-92.ZD

Abstract

OBJECTIVE

To observe the effect of vitamin C and E on blood lead (Pb) levels and SOD, GSH-Px, NOS activity and NO, MDA content in hippocampus of rats with lead poisoning.

METHODS

Rat lead poisoning model was established by oral administration of 0.615 mmol/L lead acetate in drinking water for 4 weeks; and animals were fed with vitamin C 100 mg/kg. bw and/or vitamin E 100 mg/kg. bw for 1 week. Then blood Pb levels and SOD, GSH-Px, NOS activity and MDA, NO contents in hippocampus of rats were determined by corresponding kits.

RESULT

Compared with control group, blood Pb level was decreased significantly (P<0.05) after given vitamin C, vitamin E or combination of vitamin C and E. The concentrations of SOD, GSH-Px, NO and NOS were significantly higher in vitamin C and/or E groups than those in control group (P<0.05). The concentration of MDA in vitamin treatment groups was significantly lower than that in lead control group (P<0.05); furthermore concentration of MDA in combination of vitamin C and E group was significantly higher than that in vitamin C alone group (P<0.05).

CONCLUSION

Administration of vitamin C and E can decrease blood lead level, alleviate damage of lipid peroxidation in hippocampus by lead toxicity and reverse NO, NOS levels in rats with lead poisoning.

Authors+Show Affiliations

Department of Pharmacy, City College, Zhejiang University, Hangzhou 310015, China.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article
Research Support, Non-U.S. Gov't

Language

chi

PubMed ID

18422281

Citation

Li, Xiang-rong, et al. "[Effect of Vitamin C and E On Antioxidative Enzyme, NOS Activity and NO Contents in Hippocampus of Rats With Lead Poisoning]." Zhejiang Da Xue Xue Bao. Yi Xue Ban = Journal of Zhejiang University. Medical Sciences, vol. 37, no. 2, 2008, pp. 189-92.
Li XR, Long YH, Fang X, et al. [Effect of vitamin C and E on antioxidative enzyme, NOS activity and NO contents in hippocampus of rats with lead poisoning]. Zhejiang Da Xue Xue Bao Yi Xue Ban. 2008;37(2):189-92.
Li, X. R., Long, Y. H., Fang, X., & Liu, X. G. (2008). [Effect of vitamin C and E on antioxidative enzyme, NOS activity and NO contents in hippocampus of rats with lead poisoning]. Zhejiang Da Xue Xue Bao. Yi Xue Ban = Journal of Zhejiang University. Medical Sciences, 37(2), 189-92.
Li XR, et al. [Effect of Vitamin C and E On Antioxidative Enzyme, NOS Activity and NO Contents in Hippocampus of Rats With Lead Poisoning]. Zhejiang Da Xue Xue Bao Yi Xue Ban. 2008;37(2):189-92. PubMed PMID: 18422281.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Effect of vitamin C and E on antioxidative enzyme, NOS activity and NO contents in hippocampus of rats with lead poisoning]. AU - Li,Xiang-rong, AU - Long,Yu-hong, AU - Fang,Xiao, AU - Liu,Xiao-guang, PY - 2008/4/22/pubmed PY - 2010/3/31/medline PY - 2008/4/22/entrez SP - 189 EP - 92 JF - Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences JO - Zhejiang Da Xue Xue Bao Yi Xue Ban VL - 37 IS - 2 N2 - OBJECTIVE: To observe the effect of vitamin C and E on blood lead (Pb) levels and SOD, GSH-Px, NOS activity and NO, MDA content in hippocampus of rats with lead poisoning. METHODS: Rat lead poisoning model was established by oral administration of 0.615 mmol/L lead acetate in drinking water for 4 weeks; and animals were fed with vitamin C 100 mg/kg. bw and/or vitamin E 100 mg/kg. bw for 1 week. Then blood Pb levels and SOD, GSH-Px, NOS activity and MDA, NO contents in hippocampus of rats were determined by corresponding kits. RESULT: Compared with control group, blood Pb level was decreased significantly (P<0.05) after given vitamin C, vitamin E or combination of vitamin C and E. The concentrations of SOD, GSH-Px, NO and NOS were significantly higher in vitamin C and/or E groups than those in control group (P<0.05). The concentration of MDA in vitamin treatment groups was significantly lower than that in lead control group (P<0.05); furthermore concentration of MDA in combination of vitamin C and E group was significantly higher than that in vitamin C alone group (P<0.05). CONCLUSION: Administration of vitamin C and E can decrease blood lead level, alleviate damage of lipid peroxidation in hippocampus by lead toxicity and reverse NO, NOS levels in rats with lead poisoning. SN - 1008-9292 UR - https://www.unboundmedicine.com/medline/citation/18422281/[Effect_of_vitamin_C_and_E_on_antioxidative_enzyme_NOS_activity_and_NO_contents_in_hippocampus_of_rats_with_lead_poisoning]_ L2 - https://medlineplus.gov/vitaminc.html DB - PRIME DP - Unbound Medicine ER -