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A review of irritable bowel syndrome and an update on therapeutic approaches.

Abstract

BACKGROUND

Irritable bowel syndrome is a common disorder that is associated with a significant impact on both affected individuals and society. While the pathophysiology of irritable bowel syndrome remains unknown, knowledge regarding the normal and abnormal functions of the gut and its complex interactions with the body's nervous systems continue to shed light on the multifactiorial origins of irritable bowel syndrome symptoms.

OBJECTIVE

This article provides an overview of the current knowledge on the therapeutic approaches to irritable bowel syndrome.

METHODS

A search of the online bibliographic databases MEDLINE and EMBASE was performed in order to identify all relevant articles published between 1980 and 2008. The search was enhanced with the use of a medical librarian. Bibliographies from potentially relevant articles were manually searched.

RESULTS/CONCLUSIONS

The therapeutic options for irritable bowel syndrome are rapidly evolving beyond traditional symptom-based therapies, such as fiber, antispasmodics, antidiarrheals and laxatives and are moving towards agents with organ-specific receptor selectivity directed, in many cases, at specific gastrointestinal functions.

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  • Publisher Full Text
  • Authors+Show Affiliations

    ,

    Uniformed Services University of the Health Sciences, National Naval Medical Center, Department of Gastroenterology, 8901 Wisconsin Avenue, Bethesda, MD 20889, USA.

    Source

    Expert opinion on pharmacotherapy 9:7 2008 May pg 1129-43

    MeSH

    Antidiarrheals
    Dietary Fiber
    Drug Delivery Systems
    Gastrointestinal Agents
    Humans
    Irritable Bowel Syndrome
    Laxatives
    Parasympatholytics

    Pub Type(s)

    Journal Article
    Review

    Language

    eng

    PubMed ID

    18422471

    Citation

    Bassett, John T., and Brooks D. Cash. "A Review of Irritable Bowel Syndrome and an Update On Therapeutic Approaches." Expert Opinion On Pharmacotherapy, vol. 9, no. 7, 2008, pp. 1129-43.
    Bassett JT, Cash BD. A review of irritable bowel syndrome and an update on therapeutic approaches. Expert Opin Pharmacother. 2008;9(7):1129-43.
    Bassett, J. T., & Cash, B. D. (2008). A review of irritable bowel syndrome and an update on therapeutic approaches. Expert Opinion On Pharmacotherapy, 9(7), pp. 1129-43. doi:10.1517/14656566.9.7.1129.
    Bassett JT, Cash BD. A Review of Irritable Bowel Syndrome and an Update On Therapeutic Approaches. Expert Opin Pharmacother. 2008;9(7):1129-43. PubMed PMID: 18422471.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - A review of irritable bowel syndrome and an update on therapeutic approaches. AU - Bassett,John T, AU - Cash,Brooks D, PY - 2008/4/22/pubmed PY - 2008/5/10/medline PY - 2008/4/22/entrez SP - 1129 EP - 43 JF - Expert opinion on pharmacotherapy JO - Expert Opin Pharmacother VL - 9 IS - 7 N2 - BACKGROUND: Irritable bowel syndrome is a common disorder that is associated with a significant impact on both affected individuals and society. While the pathophysiology of irritable bowel syndrome remains unknown, knowledge regarding the normal and abnormal functions of the gut and its complex interactions with the body's nervous systems continue to shed light on the multifactiorial origins of irritable bowel syndrome symptoms. OBJECTIVE: This article provides an overview of the current knowledge on the therapeutic approaches to irritable bowel syndrome. METHODS: A search of the online bibliographic databases MEDLINE and EMBASE was performed in order to identify all relevant articles published between 1980 and 2008. The search was enhanced with the use of a medical librarian. Bibliographies from potentially relevant articles were manually searched. RESULTS/CONCLUSIONS: The therapeutic options for irritable bowel syndrome are rapidly evolving beyond traditional symptom-based therapies, such as fiber, antispasmodics, antidiarrheals and laxatives and are moving towards agents with organ-specific receptor selectivity directed, in many cases, at specific gastrointestinal functions. SN - 1744-7666 UR - https://www.unboundmedicine.com/medline/citation/18422471/A_review_of_irritable_bowel_syndrome_and_an_update_on_therapeutic_approaches_ L2 - http://www.tandfonline.com/doi/full/10.1517/14656566.9.7.1129 DB - PRIME DP - Unbound Medicine ER -