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Relationship between low ultraviolet B irradiance and higher breast cancer risk in 107 countries.
Breast J. 2008 May-Jun; 14(3):255-60.BJ

Abstract

Epidemiological data show an inverse relationship between vitamin D levels and breast cancer incidence. This study investigates the relationship of modeled and measured serum 25-hydroxyvitamin D [25(OH)D] levels with age-standardized incidence rates of breast cancer in 107 countries. The hypothesis being tested is that breast cancer incidence is inversely related to geographically-dependent cutaneous sunlight exposure. A multiple regression approach was used to examine the contributions of ultraviolet B (UVB) irradiance to age-standardized incidence rates of breast cancer in the 107 countries with data on these covariates-total column ozone thickness, per capita intake of alcohol and energy from animal and vegetable sources, cigarettes, proportion of female population overweight, and total fertility. Age-standardized incidence rates were substantially higher at latitudes distant from the equator (R2 = 0.43, p < 0.0001). The dose-response gradient between modeled serum 25(OH)D levels and incidence rates of breast cancer followed a standard inverse dose-response curve. Increasing increments in serum 25(OH)D in the range above 22 ng/mL were associated with incrementally lower incidence rates of breast cancer. According to multiple regression, UVB irradiance adjusted for cloud cover was inversely associated with incidence rates (p = 0.04) after controlling for covariates. Intake of energy from animal sources was also positively associated with incidence rates (p < 0.01). The overall coefficient of determination, R2, was 0.81 (p < 0.0001). There was a protective effect of UVB irradiance on risk of breast cancer that was independent of fertility rate, proportion of the population overweight, alcohol intake, animal energy intake, and other covariates.

Authors+Show Affiliations

Department of Family and Preventive Medicine, University of California San Diego, La Jolla, California 92093-0631, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, Non-P.H.S.

Language

eng

PubMed ID

18422861

Citation

Mohr, Sharif B., et al. "Relationship Between Low Ultraviolet B Irradiance and Higher Breast Cancer Risk in 107 Countries." The Breast Journal, vol. 14, no. 3, 2008, pp. 255-60.
Mohr SB, Garland CF, Gorham ED, et al. Relationship between low ultraviolet B irradiance and higher breast cancer risk in 107 countries. Breast J. 2008;14(3):255-60.
Mohr, S. B., Garland, C. F., Gorham, E. D., Grant, W. B., & Garland, F. C. (2008). Relationship between low ultraviolet B irradiance and higher breast cancer risk in 107 countries. The Breast Journal, 14(3), 255-60. https://doi.org/10.1111/j.1524-4741.2008.00571.x
Mohr SB, et al. Relationship Between Low Ultraviolet B Irradiance and Higher Breast Cancer Risk in 107 Countries. Breast J. 2008 May-Jun;14(3):255-60. PubMed PMID: 18422861.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Relationship between low ultraviolet B irradiance and higher breast cancer risk in 107 countries. AU - Mohr,Sharif B, AU - Garland,Cedric F, AU - Gorham,Edward D, AU - Grant,William B, AU - Garland,Frank C, Y1 - 2008/04/17/ PY - 2008/4/22/pubmed PY - 2008/6/18/medline PY - 2008/4/22/entrez SP - 255 EP - 60 JF - The breast journal JO - Breast J VL - 14 IS - 3 N2 - Epidemiological data show an inverse relationship between vitamin D levels and breast cancer incidence. This study investigates the relationship of modeled and measured serum 25-hydroxyvitamin D [25(OH)D] levels with age-standardized incidence rates of breast cancer in 107 countries. The hypothesis being tested is that breast cancer incidence is inversely related to geographically-dependent cutaneous sunlight exposure. A multiple regression approach was used to examine the contributions of ultraviolet B (UVB) irradiance to age-standardized incidence rates of breast cancer in the 107 countries with data on these covariates-total column ozone thickness, per capita intake of alcohol and energy from animal and vegetable sources, cigarettes, proportion of female population overweight, and total fertility. Age-standardized incidence rates were substantially higher at latitudes distant from the equator (R2 = 0.43, p < 0.0001). The dose-response gradient between modeled serum 25(OH)D levels and incidence rates of breast cancer followed a standard inverse dose-response curve. Increasing increments in serum 25(OH)D in the range above 22 ng/mL were associated with incrementally lower incidence rates of breast cancer. According to multiple regression, UVB irradiance adjusted for cloud cover was inversely associated with incidence rates (p = 0.04) after controlling for covariates. Intake of energy from animal sources was also positively associated with incidence rates (p < 0.01). The overall coefficient of determination, R2, was 0.81 (p < 0.0001). There was a protective effect of UVB irradiance on risk of breast cancer that was independent of fertility rate, proportion of the population overweight, alcohol intake, animal energy intake, and other covariates. SN - 1524-4741 UR - https://www.unboundmedicine.com/medline/citation/18422861/Relationship_between_low_ultraviolet_B_irradiance_and_higher_breast_cancer_risk_in_107_countries_ L2 - https://doi.org/10.1111/j.1524-4741.2008.00571.x DB - PRIME DP - Unbound Medicine ER -