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Antioxidant therapy in male infertility.

Abstract

Although reports have suggested the benefit of antioxidant treatment of infertile men, many studies also show no effect. Most studies in the literature are not randomized, placebo controlled, or double blinded in design, which makes it difficult to differentiate regression toward the mean from true positive treatment effects. The small patient sample sizes and varying male populations also add to the difficulty in comparing studies. Pregnancy, the most relevant outcome parameter, is rarely reported. Ideally, patients would be selected based on oxidative stress levels, and improvement in these levels would be correlated to improvement in pregnancy rates. Until those studies are performed, the use of antioxidants for the treatment of male infertility remains empiric.

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  • Authors+Show Affiliations

    ,

    The Warren Alpert Medical School of Brown University, Division of Urology, Rhode Island Hospital, Box G-A Providence, RI 02912, USA.

    Source

    The Urologic clinics of North America 35:2 2008 May pg 319-30, x

    MeSH

    Antioxidants
    Humans
    Infertility, Male
    Male
    Oxidative Stress

    Pub Type(s)

    Journal Article
    Review

    Language

    eng

    PubMed ID

    18423251

    Citation

    Patel, Sutchin R., and Mark Sigman. "Antioxidant Therapy in Male Infertility." The Urologic Clinics of North America, vol. 35, no. 2, 2008, pp. 319-30, x.
    Patel SR, Sigman M. Antioxidant therapy in male infertility. Urol Clin North Am. 2008;35(2):319-30, x.
    Patel, S. R., & Sigman, M. (2008). Antioxidant therapy in male infertility. The Urologic Clinics of North America, 35(2), pp. 319-30, x. doi:10.1016/j.ucl.2008.01.009.
    Patel SR, Sigman M. Antioxidant Therapy in Male Infertility. Urol Clin North Am. 2008;35(2):319-30, x. PubMed PMID: 18423251.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Antioxidant therapy in male infertility. AU - Patel,Sutchin R, AU - Sigman,Mark, PY - 2008/4/22/pubmed PY - 2008/7/17/medline PY - 2008/4/22/entrez SP - 319-30, x JF - The Urologic clinics of North America JO - Urol. Clin. North Am. VL - 35 IS - 2 N2 - Although reports have suggested the benefit of antioxidant treatment of infertile men, many studies also show no effect. Most studies in the literature are not randomized, placebo controlled, or double blinded in design, which makes it difficult to differentiate regression toward the mean from true positive treatment effects. The small patient sample sizes and varying male populations also add to the difficulty in comparing studies. Pregnancy, the most relevant outcome parameter, is rarely reported. Ideally, patients would be selected based on oxidative stress levels, and improvement in these levels would be correlated to improvement in pregnancy rates. Until those studies are performed, the use of antioxidants for the treatment of male infertility remains empiric. SN - 0094-0143 UR - https://www.unboundmedicine.com/medline/citation/18423251/Antioxidant_therapy_in_male_infertility_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0094-0143(08)00011-6 DB - PRIME DP - Unbound Medicine ER -