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A life course of adiposity and dementia.

Abstract

Adiposity, commonly measured as body mass index (BMI), may influence or be influenced by brain structures and functions involved in dementia processes. Adipose tissue changes in degree and intensity over the lifespan, and has been shown to influence brain development in relationship to early and late measures of cognitive function, intelligence, and disorders of cognition such as dementia. A lower BMI is associated with prevalent dementia, potentially due to underlying brain pathologies and correspondingly greater rates of BMI or weight decline observed during the years immediately preceding clinical dementia onset. However, high BMI during mid-life or at least approximately 5-10 years preceding clinical dementia onset may increase risk. The interplay of adiposity and the brain occurring over the course of the lifespan will be discussed in relationship to developmental origins, mid-life sequelae, disruptions in brain structure and function, and late-life changes in cognition and dementia. Characterizing the life course of adiposity among those who do and do not become demented enhances understanding of biological underpinnings relevant for understanding the etiologies of both dementia and obesity and their co-existence.

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  • Publisher Full Text
  • Authors+Show Affiliations

    Institute of Neuroscience and Physiology, Section for Psychiatry and Neurochemistry, Sahlgrenska Academy at Göteborg University, Sweden. deb.gustafson@neuro.gu.se

    Source

    European journal of pharmacology 585:1 2008 May 06 pg 163-75

    MeSH

    Adipose Tissue
    Adiposity
    Adult
    Age Factors
    Aged
    Body Mass Index
    Dementia
    Humans
    Middle Aged
    Obesity
    Risk Factors

    Pub Type(s)

    Journal Article
    Research Support, N.I.H., Extramural
    Research Support, Non-U.S. Gov't
    Review

    Language

    eng

    PubMed ID

    18423446

    Citation

    Gustafson, Deborah. "A Life Course of Adiposity and Dementia." European Journal of Pharmacology, vol. 585, no. 1, 2008, pp. 163-75.
    Gustafson D. A life course of adiposity and dementia. Eur J Pharmacol. 2008;585(1):163-75.
    Gustafson, D. (2008). A life course of adiposity and dementia. European Journal of Pharmacology, 585(1), pp. 163-75. doi:10.1016/j.ejphar.2008.01.052.
    Gustafson D. A Life Course of Adiposity and Dementia. Eur J Pharmacol. 2008 May 6;585(1):163-75. PubMed PMID: 18423446.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - A life course of adiposity and dementia. A1 - Gustafson,Deborah, Y1 - 2008/03/04/ PY - 2007/10/23/received PY - 2007/12/11/revised PY - 2008/01/21/accepted PY - 2008/4/22/pubmed PY - 2008/11/1/medline PY - 2008/4/22/entrez SP - 163 EP - 75 JF - European journal of pharmacology JO - Eur. J. Pharmacol. VL - 585 IS - 1 N2 - Adiposity, commonly measured as body mass index (BMI), may influence or be influenced by brain structures and functions involved in dementia processes. Adipose tissue changes in degree and intensity over the lifespan, and has been shown to influence brain development in relationship to early and late measures of cognitive function, intelligence, and disorders of cognition such as dementia. A lower BMI is associated with prevalent dementia, potentially due to underlying brain pathologies and correspondingly greater rates of BMI or weight decline observed during the years immediately preceding clinical dementia onset. However, high BMI during mid-life or at least approximately 5-10 years preceding clinical dementia onset may increase risk. The interplay of adiposity and the brain occurring over the course of the lifespan will be discussed in relationship to developmental origins, mid-life sequelae, disruptions in brain structure and function, and late-life changes in cognition and dementia. Characterizing the life course of adiposity among those who do and do not become demented enhances understanding of biological underpinnings relevant for understanding the etiologies of both dementia and obesity and their co-existence. SN - 0014-2999 UR - https://www.unboundmedicine.com/medline/citation/18423446/A_life_course_of_adiposity_and_dementia_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0014-2999(08)00232-X DB - PRIME DP - Unbound Medicine ER -