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Posttraumatic stress disorder, cognitive function and quality of life in patients with schizophrenia.
Psychiatry Res. 2008 May 30; 159(1-2):140-6.PR

Abstract

The purpose of the present study was to assess posttraumatic stress disorder (PTSD), cognitive function, and quality of life in patients with schizophrenia who had a self-reported history of trauma exposure. Outpatients diagnosed with schizophrenia or schizoaffective disorder were referred to the study. Each patient was assessed with the Positive and Negative Syndrome Scale (PANSS), the Harvard Trauma Questionnaire (HTQ), a cognitive assessment battery, Heinrich's Quality of Life Scale (QLS), and the Behavior and Symptom Identification Scale (BASIS). Eighty-seven subjects who reported experiencing at least one traumatic event were included in the study. Fifteen of 87 (17%) met the DSM-IV criteria for PTSD. The PTSD group had significantly worse overall cognitive performance than the non-PTSD group, especially in the domains of attention, working memory and executive function. In addition, the PTSD group showed significantly worse self-rated quality of life as measured by the BASIS total score. The development of PTSD is associated with poor cognitive function and subjectively, but not objectively, rated low quality of life in patients with schizophrenia. Evaluating PTSD in patients with schizophrenia could have important implications from both clinical and research perspectives.

Authors+Show Affiliations

Schizophrenia Program, Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA. xfan@partners.orgNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

18423611

Citation

Fan, Xiaoduo, et al. "Posttraumatic Stress Disorder, Cognitive Function and Quality of Life in Patients With Schizophrenia." Psychiatry Research, vol. 159, no. 1-2, 2008, pp. 140-6.
Fan X, Henderson DC, Nguyen DD, et al. Posttraumatic stress disorder, cognitive function and quality of life in patients with schizophrenia. Psychiatry Res. 2008;159(1-2):140-6.
Fan, X., Henderson, D. C., Nguyen, D. D., Cather, C., Freudenreich, O., Evins, A. E., Borba, C. P., & Goff, D. C. (2008). Posttraumatic stress disorder, cognitive function and quality of life in patients with schizophrenia. Psychiatry Research, 159(1-2), 140-6. https://doi.org/10.1016/j.psychres.2007.10.012
Fan X, et al. Posttraumatic Stress Disorder, Cognitive Function and Quality of Life in Patients With Schizophrenia. Psychiatry Res. 2008 May 30;159(1-2):140-6. PubMed PMID: 18423611.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Posttraumatic stress disorder, cognitive function and quality of life in patients with schizophrenia. AU - Fan,Xiaoduo, AU - Henderson,David C, AU - Nguyen,Dana D, AU - Cather,Corinne, AU - Freudenreich,Oliver, AU - Evins,A Eden, AU - Borba,Christina P, AU - Goff,Donald C, Y1 - 2008/04/21/ PY - 2006/12/25/received PY - 2007/10/17/revised PY - 2007/10/22/accepted PY - 2008/4/22/pubmed PY - 2008/7/26/medline PY - 2008/4/22/entrez SP - 140 EP - 6 JF - Psychiatry research JO - Psychiatry Res VL - 159 IS - 1-2 N2 - The purpose of the present study was to assess posttraumatic stress disorder (PTSD), cognitive function, and quality of life in patients with schizophrenia who had a self-reported history of trauma exposure. Outpatients diagnosed with schizophrenia or schizoaffective disorder were referred to the study. Each patient was assessed with the Positive and Negative Syndrome Scale (PANSS), the Harvard Trauma Questionnaire (HTQ), a cognitive assessment battery, Heinrich's Quality of Life Scale (QLS), and the Behavior and Symptom Identification Scale (BASIS). Eighty-seven subjects who reported experiencing at least one traumatic event were included in the study. Fifteen of 87 (17%) met the DSM-IV criteria for PTSD. The PTSD group had significantly worse overall cognitive performance than the non-PTSD group, especially in the domains of attention, working memory and executive function. In addition, the PTSD group showed significantly worse self-rated quality of life as measured by the BASIS total score. The development of PTSD is associated with poor cognitive function and subjectively, but not objectively, rated low quality of life in patients with schizophrenia. Evaluating PTSD in patients with schizophrenia could have important implications from both clinical and research perspectives. SN - 0165-1781 UR - https://www.unboundmedicine.com/medline/citation/18423611/Posttraumatic_stress_disorder_cognitive_function_and_quality_of_life_in_patients_with_schizophrenia_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0165-1781(07)00367-8 DB - PRIME DP - Unbound Medicine ER -