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Normal sublingual microcirculation during painful crisis in sickle cell disease.
Microvasc Res. 2008 May; 76(1):57-60.MR

Abstract

Obstruction of the microcirculation is the most important cause of painful crisis in sickle cell disease (SCD). Extensive microvascular obstruction has been observed in mouse models of SCD. A technique to determine the extent of the microcirculatory obstructions in humans may be helpful in the clinical setting and for research purposes. Therefore, we measured sublingual microcirculation longitudinally in patients with SCD admitted with painful crisis. Sublingual microcirculation was recorded with side-stream darkfield (SDF) imaging and semi-quantified with a microvascular flow index (MFI) on a range from 0 to 4 (arbitrary units; from 0 (no flow) to 4 (hyperdynamic flow)). Thirteen consecutive adult sickle cell patients admitted with painful crises were included and provided 47 measurements of MFI in 14 episodes of painful crisis. Seven patients provided baseline measurements and seven healthy controls were studied. The mean (+/-standard error of the mean) MFI during painful crisis was 2.6+/-0.1 and did not change during the painful crisis. The mean MFI of patients with SCD during steady state (2.7+/-0.1) and the mean MFI of the controls (2.7+/-0.1) were not different from the mean MFI during painful crisis. During painful crisis irregular microvascular perfusion, expressed by the distribution width of the microvascular blood flow velocity, correlated negatively (r=-0.484; P=0.002) with hemoglobin concentration. We conclude that sublingual microcirculatory blood flow velocity is not disturbed in sickle cell patients during painful crisis.

Authors+Show Affiliations

Department of Hematology, Academic Medical Center, Amsterdam, The Netherlands.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

18423765

Citation

van Beers, Eduard J., et al. "Normal Sublingual Microcirculation During Painful Crisis in Sickle Cell Disease." Microvascular Research, vol. 76, no. 1, 2008, pp. 57-60.
van Beers EJ, Goedhart PT, Unger M, et al. Normal sublingual microcirculation during painful crisis in sickle cell disease. Microvasc Res. 2008;76(1):57-60.
van Beers, E. J., Goedhart, P. T., Unger, M., Biemond, B. J., & Ince, C. (2008). Normal sublingual microcirculation during painful crisis in sickle cell disease. Microvascular Research, 76(1), 57-60. https://doi.org/10.1016/j.mvr.2008.02.001
van Beers EJ, et al. Normal Sublingual Microcirculation During Painful Crisis in Sickle Cell Disease. Microvasc Res. 2008;76(1):57-60. PubMed PMID: 18423765.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Normal sublingual microcirculation during painful crisis in sickle cell disease. AU - van Beers,Eduard J, AU - Goedhart,Peter T, AU - Unger,Michiel, AU - Biemond,Bart J, AU - Ince,Can, Y1 - 2008/03/12/ PY - 2007/07/10/received PY - 2008/01/19/revised PY - 2008/02/13/accepted PY - 2008/4/22/pubmed PY - 2008/11/4/medline PY - 2008/4/22/entrez SP - 57 EP - 60 JF - Microvascular research JO - Microvasc. Res. VL - 76 IS - 1 N2 - Obstruction of the microcirculation is the most important cause of painful crisis in sickle cell disease (SCD). Extensive microvascular obstruction has been observed in mouse models of SCD. A technique to determine the extent of the microcirculatory obstructions in humans may be helpful in the clinical setting and for research purposes. Therefore, we measured sublingual microcirculation longitudinally in patients with SCD admitted with painful crisis. Sublingual microcirculation was recorded with side-stream darkfield (SDF) imaging and semi-quantified with a microvascular flow index (MFI) on a range from 0 to 4 (arbitrary units; from 0 (no flow) to 4 (hyperdynamic flow)). Thirteen consecutive adult sickle cell patients admitted with painful crises were included and provided 47 measurements of MFI in 14 episodes of painful crisis. Seven patients provided baseline measurements and seven healthy controls were studied. The mean (+/-standard error of the mean) MFI during painful crisis was 2.6+/-0.1 and did not change during the painful crisis. The mean MFI of patients with SCD during steady state (2.7+/-0.1) and the mean MFI of the controls (2.7+/-0.1) were not different from the mean MFI during painful crisis. During painful crisis irregular microvascular perfusion, expressed by the distribution width of the microvascular blood flow velocity, correlated negatively (r=-0.484; P=0.002) with hemoglobin concentration. We conclude that sublingual microcirculatory blood flow velocity is not disturbed in sickle cell patients during painful crisis. SN - 1095-9319 UR - https://www.unboundmedicine.com/medline/citation/18423765/Normal_sublingual_microcirculation_during_painful_crisis_in_sickle_cell_disease_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0026-2862(08)00028-9 DB - PRIME DP - Unbound Medicine ER -