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14-3-3 regulates life span by both DAF-16-dependent and -independent mechanisms in Caenorhabditis elegans.
Exp Gerontol. 2008 Jun; 43(6):505-19.EG

Abstract

Caenorhabditis elegans life span, stress resistance and metabolism are regulated by the Insulin/IGF-1/DAF-2/DAF-16 pathway. DAF-16, a member of FOXO/Forkhead transcription factor family, can be targeted by 14-3-3 proteins to promote stress resistance. We have identified a 14-3-3 C. elegans homolog which promotes life span by both DAF-2-dependent and -independent mechanisms and by an unexpected DAF-16-independent mechanism. Our results demonstrate that C. elegans 14-3-3 proteins modulate stress-responsive genes throughout adulthood. In conclusion, 14-3-3 can be considered as an acute stress-responsive regulator as well as a sustained modulator of the Insulin/IGF-1/DAF-2/DAF-16 regulatory pathway in promoting life expectancy of growing old worms.

Authors+Show Affiliations

CRBM-CNRS, 1919 route de Mende, F34293 Montpellier cedex 5, France.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18423931

Citation

Araiz, Caroline, et al. "14-3-3 Regulates Life Span By Both DAF-16-dependent and -independent Mechanisms in Caenorhabditis Elegans." Experimental Gerontology, vol. 43, no. 6, 2008, pp. 505-19.
Araiz C, Château MT, Galas S. 14-3-3 regulates life span by both DAF-16-dependent and -independent mechanisms in Caenorhabditis elegans. Exp Gerontol. 2008;43(6):505-19.
Araiz, C., Château, M. T., & Galas, S. (2008). 14-3-3 regulates life span by both DAF-16-dependent and -independent mechanisms in Caenorhabditis elegans. Experimental Gerontology, 43(6), 505-19. https://doi.org/10.1016/j.exger.2008.03.001
Araiz C, Château MT, Galas S. 14-3-3 Regulates Life Span By Both DAF-16-dependent and -independent Mechanisms in Caenorhabditis Elegans. Exp Gerontol. 2008;43(6):505-19. PubMed PMID: 18423931.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - 14-3-3 regulates life span by both DAF-16-dependent and -independent mechanisms in Caenorhabditis elegans. AU - Araiz,Caroline, AU - Château,Marie-Thérèse, AU - Galas,Simon, Y1 - 2008/03/18/ PY - 2007/05/04/received PY - 2008/02/13/revised PY - 2008/03/04/accepted PY - 2008/4/22/pubmed PY - 2008/12/17/medline PY - 2008/4/22/entrez SP - 505 EP - 19 JF - Experimental gerontology JO - Exp. Gerontol. VL - 43 IS - 6 N2 - Caenorhabditis elegans life span, stress resistance and metabolism are regulated by the Insulin/IGF-1/DAF-2/DAF-16 pathway. DAF-16, a member of FOXO/Forkhead transcription factor family, can be targeted by 14-3-3 proteins to promote stress resistance. We have identified a 14-3-3 C. elegans homolog which promotes life span by both DAF-2-dependent and -independent mechanisms and by an unexpected DAF-16-independent mechanism. Our results demonstrate that C. elegans 14-3-3 proteins modulate stress-responsive genes throughout adulthood. In conclusion, 14-3-3 can be considered as an acute stress-responsive regulator as well as a sustained modulator of the Insulin/IGF-1/DAF-2/DAF-16 regulatory pathway in promoting life expectancy of growing old worms. SN - 0531-5565 UR - https://www.unboundmedicine.com/medline/citation/18423931/14_3_3_regulates_life_span_by_both_DAF_16_dependent_and__independent_mechanisms_in_Caenorhabditis_elegans_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0531-5565(08)00083-1 DB - PRIME DP - Unbound Medicine ER -