Tags

Type your tag names separated by a space and hit enter

First isolation of EBLV-2 in Germany.
Vet Microbiol. 2008 Sep 18; 131(1-2):26-34.VM

Abstract

In Europe, rabies in bats is caused by European Bat Lyssavirus (EBLV) type 1 (EBLV-1) or type 2 (EBLV-2) which form two distinct genotypes (gt 5 and 6) within the genus Lyssavirus of the family of Rhadoviridae. Spill-over infections of EBLV in humans have caused fatal rabies encephalitis and highlighted the relevance of this wildlife disease for public health. The vast majority of the 831 European bat rabies cases reported between 1977 and 2006 were identified as EBLV-1. Only few virus isolates originating from Switzerland, The Netherlands and the United Kingdom were characterized as EBLV-2. Here we report the first EBLV-2 case detected in Germany in a Daubenton's bat (Myotis daubentonii) in August 2007. The bat showed clinical signs of disorders of the central nervous system and subsequently tested positive for rabies. The virus was isolated and characterized as EBLV-2 based on its antigen pattern and by nucleotide sequencing. Phylogenetic analysis indicated an association to EBLV-2 isolates from Switzerland which correlates with the origin of the bat close to the Swiss border.

Authors+Show Affiliations

Friedrich-Loeffler-Institute, Federal Research Institute for Animal Health, WHO Collaborating Centre for Rabies Surveillance and Research, 16868 Wusterhausen, Germany. Conrad.Freuling@fli.bund.deNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

18424021

Citation

Freuling, Conrad, et al. "First Isolation of EBLV-2 in Germany." Veterinary Microbiology, vol. 131, no. 1-2, 2008, pp. 26-34.
Freuling C, Grossmann E, Conraths FJ, et al. First isolation of EBLV-2 in Germany. Vet Microbiol. 2008;131(1-2):26-34.
Freuling, C., Grossmann, E., Conraths, F. J., Schameitat, A., Kliemt, J., Auer, E., Greiser-Wilke, I., & Müller, T. (2008). First isolation of EBLV-2 in Germany. Veterinary Microbiology, 131(1-2), 26-34. https://doi.org/10.1016/j.vetmic.2008.02.028
Freuling C, et al. First Isolation of EBLV-2 in Germany. Vet Microbiol. 2008 Sep 18;131(1-2):26-34. PubMed PMID: 18424021.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - First isolation of EBLV-2 in Germany. AU - Freuling,Conrad, AU - Grossmann,Ernst, AU - Conraths,Franz J, AU - Schameitat,Astrid, AU - Kliemt,Jeannette, AU - Auer,Ernst, AU - Greiser-Wilke,Irene, AU - Müller,Thomas, Y1 - 2008/03/07/ PY - 2007/12/12/received PY - 2008/02/14/revised PY - 2008/02/26/accepted PY - 2008/4/22/pubmed PY - 2009/2/6/medline PY - 2008/4/22/entrez SP - 26 EP - 34 JF - Veterinary microbiology JO - Vet Microbiol VL - 131 IS - 1-2 N2 - In Europe, rabies in bats is caused by European Bat Lyssavirus (EBLV) type 1 (EBLV-1) or type 2 (EBLV-2) which form two distinct genotypes (gt 5 and 6) within the genus Lyssavirus of the family of Rhadoviridae. Spill-over infections of EBLV in humans have caused fatal rabies encephalitis and highlighted the relevance of this wildlife disease for public health. The vast majority of the 831 European bat rabies cases reported between 1977 and 2006 were identified as EBLV-1. Only few virus isolates originating from Switzerland, The Netherlands and the United Kingdom were characterized as EBLV-2. Here we report the first EBLV-2 case detected in Germany in a Daubenton's bat (Myotis daubentonii) in August 2007. The bat showed clinical signs of disorders of the central nervous system and subsequently tested positive for rabies. The virus was isolated and characterized as EBLV-2 based on its antigen pattern and by nucleotide sequencing. Phylogenetic analysis indicated an association to EBLV-2 isolates from Switzerland which correlates with the origin of the bat close to the Swiss border. SN - 0378-1135 UR - https://www.unboundmedicine.com/medline/citation/18424021/First_isolation_of_EBLV_2_in_Germany_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0378-1135(08)00088-6 DB - PRIME DP - Unbound Medicine ER -