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Potential ergogenic effects of L-arginine against oxidative and inflammatory stress induced by acute exercise in aging rats.
Exp Gerontol. 2008 Jun; 43(6):571-7.EG

Abstract

In this study, we report protective effects of dietary L-arginine (L-Arg) supplementation against oxidative stress and inflammation in aging rats during exhaustive exercise. Thirty 18-month-old male Sprague-Dawley rats were randomly divided into four groups: sedentary control (SC); sedentary control with L-Arg treatment (SC+Arg); exhaustive exercise (E); and exhaustive exercise with L-Arg treatment (E+Arg). Rats in groups SC+Arg and E+Arg received a 2% L-Arg diet. Rats in groups E and E+Arg performed an exhaustive running test on a treadmill. The mean duration of exercise differed significantly between groups E and E+Arg (51+/-6 versus 63+/-3min). Results showed significant increases in xanthine oxidase (XO) and myeloperoxidase (MPO) activities and in lipid peroxidation end-product (malondialdehyde, MDA) levels of myocardial, muscular, hepatic, pulmonary, and renal tissues of exercised rats compared with SC and SC+Arg rats. The increased XO and MPO activities and MDA levels significantly decreased in exercised rats that were fed a diet supplemented with L-Arg. We also found that L-Arg supplementation prevented exhaustive exercise-induced elevations of plasma aminotransferase activity, and lactate and uric acid levels in aging rats. These findings suggest that L-Arg supplementation enhances exercise capacity and protects against oxidative damage and inflammatory responses caused by exhaustive exercise in aging rats.

Authors+Show Affiliations

Agricultural Biotechnology Research Center, Academia Sinica, Taipei 115, Taiwan, Republic of China.No affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18424033

Citation

Huang, Chi-Chang, et al. "Potential Ergogenic Effects of L-arginine Against Oxidative and Inflammatory Stress Induced By Acute Exercise in Aging Rats." Experimental Gerontology, vol. 43, no. 6, 2008, pp. 571-7.
Huang CC, Tsai SC, Lin WT. Potential ergogenic effects of L-arginine against oxidative and inflammatory stress induced by acute exercise in aging rats. Exp Gerontol. 2008;43(6):571-7.
Huang, C. C., Tsai, S. C., & Lin, W. T. (2008). Potential ergogenic effects of L-arginine against oxidative and inflammatory stress induced by acute exercise in aging rats. Experimental Gerontology, 43(6), 571-7. https://doi.org/10.1016/j.exger.2008.03.002
Huang CC, Tsai SC, Lin WT. Potential Ergogenic Effects of L-arginine Against Oxidative and Inflammatory Stress Induced By Acute Exercise in Aging Rats. Exp Gerontol. 2008;43(6):571-7. PubMed PMID: 18424033.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Potential ergogenic effects of L-arginine against oxidative and inflammatory stress induced by acute exercise in aging rats. AU - Huang,Chi-Chang, AU - Tsai,Shiow-Chwen, AU - Lin,Wan-Teng, Y1 - 2008/03/12/ PY - 2007/11/10/received PY - 2008/02/19/revised PY - 2008/03/04/accepted PY - 2008/4/22/pubmed PY - 2008/12/17/medline PY - 2008/4/22/entrez SP - 571 EP - 7 JF - Experimental gerontology JO - Exp Gerontol VL - 43 IS - 6 N2 - In this study, we report protective effects of dietary L-arginine (L-Arg) supplementation against oxidative stress and inflammation in aging rats during exhaustive exercise. Thirty 18-month-old male Sprague-Dawley rats were randomly divided into four groups: sedentary control (SC); sedentary control with L-Arg treatment (SC+Arg); exhaustive exercise (E); and exhaustive exercise with L-Arg treatment (E+Arg). Rats in groups SC+Arg and E+Arg received a 2% L-Arg diet. Rats in groups E and E+Arg performed an exhaustive running test on a treadmill. The mean duration of exercise differed significantly between groups E and E+Arg (51+/-6 versus 63+/-3min). Results showed significant increases in xanthine oxidase (XO) and myeloperoxidase (MPO) activities and in lipid peroxidation end-product (malondialdehyde, MDA) levels of myocardial, muscular, hepatic, pulmonary, and renal tissues of exercised rats compared with SC and SC+Arg rats. The increased XO and MPO activities and MDA levels significantly decreased in exercised rats that were fed a diet supplemented with L-Arg. We also found that L-Arg supplementation prevented exhaustive exercise-induced elevations of plasma aminotransferase activity, and lactate and uric acid levels in aging rats. These findings suggest that L-Arg supplementation enhances exercise capacity and protects against oxidative damage and inflammatory responses caused by exhaustive exercise in aging rats. SN - 0531-5565 UR - https://www.unboundmedicine.com/medline/citation/18424033/Potential_ergogenic_effects_of_L_arginine_against_oxidative_and_inflammatory_stress_induced_by_acute_exercise_in_aging_rats_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0531-5565(08)00082-X DB - PRIME DP - Unbound Medicine ER -