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Potential ergogenic effects of L-arginine against oxidative and inflammatory stress induced by acute exercise in aging rats.
Exp Gerontol. 2008 Jun; 43(6):571-7.EG

Abstract

In this study, we report protective effects of dietary L-arginine (L-Arg) supplementation against oxidative stress and inflammation in aging rats during exhaustive exercise. Thirty 18-month-old male Sprague-Dawley rats were randomly divided into four groups: sedentary control (SC); sedentary control with L-Arg treatment (SC+Arg); exhaustive exercise (E); and exhaustive exercise with L-Arg treatment (E+Arg). Rats in groups SC+Arg and E+Arg received a 2% L-Arg diet. Rats in groups E and E+Arg performed an exhaustive running test on a treadmill. The mean duration of exercise differed significantly between groups E and E+Arg (51+/-6 versus 63+/-3min). Results showed significant increases in xanthine oxidase (XO) and myeloperoxidase (MPO) activities and in lipid peroxidation end-product (malondialdehyde, MDA) levels of myocardial, muscular, hepatic, pulmonary, and renal tissues of exercised rats compared with SC and SC+Arg rats. The increased XO and MPO activities and MDA levels significantly decreased in exercised rats that were fed a diet supplemented with L-Arg. We also found that L-Arg supplementation prevented exhaustive exercise-induced elevations of plasma aminotransferase activity, and lactate and uric acid levels in aging rats. These findings suggest that L-Arg supplementation enhances exercise capacity and protects against oxidative damage and inflammatory responses caused by exhaustive exercise in aging rats.

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Authors+Show Affiliations

Huang CC
Agricultural Biotechnology Research Center, Academia Sinica, Taipei 115, Taiwan, Republic of China.
Tsai SC
No affiliation info available
Lin WT
No affiliation info available

MeSH

AgingAnimalsArginineBiomarkersDietary SupplementsInflammationKidneyLactic AcidLiverLungMaleMuscle, SkeletalMyocardiumOxidation-ReductionPeroxidasePhysical Conditioning, AnimalRatsRats, Sprague-DawleyXanthine Oxidase

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18424033

Citation

Huang, Chi-Chang, et al. "Potential Ergogenic Effects of L-arginine Against Oxidative and Inflammatory Stress Induced By Acute Exercise in Aging Rats." Experimental Gerontology, vol. 43, no. 6, 2008, pp. 571-7.
Huang CC, Tsai SC, Lin WT. Potential ergogenic effects of L-arginine against oxidative and inflammatory stress induced by acute exercise in aging rats. Exp Gerontol. 2008;43(6):571-7.
Huang, C. C., Tsai, S. C., & Lin, W. T. (2008). Potential ergogenic effects of L-arginine against oxidative and inflammatory stress induced by acute exercise in aging rats. Experimental Gerontology, 43(6), 571-7. https://doi.org/10.1016/j.exger.2008.03.002
Huang CC, Tsai SC, Lin WT. Potential Ergogenic Effects of L-arginine Against Oxidative and Inflammatory Stress Induced By Acute Exercise in Aging Rats. Exp Gerontol. 2008;43(6):571-7. PubMed PMID: 18424033.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Potential ergogenic effects of L-arginine against oxidative and inflammatory stress induced by acute exercise in aging rats. AU - Huang,Chi-Chang, AU - Tsai,Shiow-Chwen, AU - Lin,Wan-Teng, Y1 - 2008/03/12/ PY - 2007/11/10/received PY - 2008/02/19/revised PY - 2008/03/04/accepted PY - 2008/4/22/pubmed PY - 2008/12/17/medline PY - 2008/4/22/entrez SP - 571 EP - 7 JF - Experimental gerontology JO - Exp Gerontol VL - 43 IS - 6 N2 - In this study, we report protective effects of dietary L-arginine (L-Arg) supplementation against oxidative stress and inflammation in aging rats during exhaustive exercise. Thirty 18-month-old male Sprague-Dawley rats were randomly divided into four groups: sedentary control (SC); sedentary control with L-Arg treatment (SC+Arg); exhaustive exercise (E); and exhaustive exercise with L-Arg treatment (E+Arg). Rats in groups SC+Arg and E+Arg received a 2% L-Arg diet. Rats in groups E and E+Arg performed an exhaustive running test on a treadmill. The mean duration of exercise differed significantly between groups E and E+Arg (51+/-6 versus 63+/-3min). Results showed significant increases in xanthine oxidase (XO) and myeloperoxidase (MPO) activities and in lipid peroxidation end-product (malondialdehyde, MDA) levels of myocardial, muscular, hepatic, pulmonary, and renal tissues of exercised rats compared with SC and SC+Arg rats. The increased XO and MPO activities and MDA levels significantly decreased in exercised rats that were fed a diet supplemented with L-Arg. We also found that L-Arg supplementation prevented exhaustive exercise-induced elevations of plasma aminotransferase activity, and lactate and uric acid levels in aging rats. These findings suggest that L-Arg supplementation enhances exercise capacity and protects against oxidative damage and inflammatory responses caused by exhaustive exercise in aging rats. SN - 0531-5565 UR - https://www.unboundmedicine.com/medline/citation/18424033/Potential_ergogenic_effects_of_L_arginine_against_oxidative_and_inflammatory_stress_induced_by_acute_exercise_in_aging_rats_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0531-5565(08)00082-X DB - PRIME DP - Unbound Medicine ER -