Tags

Type your tag names separated by a space and hit enter

Dietary fats, cholesterol and iron as risk factors for Parkinson's disease.
Parkinsonism Relat Disord. 2009 Jan; 15(1):47-52.PR

Abstract

BACKGROUND

Epidemiologic findings suggest that dietary components may contribute to the etiology of Parkinson's disease (PD). This population-based case-control study evaluated PD risk and dietary intake of fats, cholesterol and iron.

METHODS

Newly diagnosed case (n=420) and age/gender/ethnicity-matched unrelated controls (n=560) were identified between 1992 and 2006 from the Group Health Cooperative health maintenance organization in western Washington State, and the University of Washington Neurology Clinic. In-person interviews elicited data on food frequency habits during most of adult life. Nutritional intakes were calculated and analyzed, with adjustments made for total energy intake (the 'nutrition density' technique).

RESULTS

Cholesterol intake in the highest quartile compared with the lowest quartile was associated with a decreased risk of PD in men (odds ratio (OR)=0.53, 95%CI: 0.33, 0.86). The highest versus the lowest quartile of dietary iron increased PD risk in men (OR=1.82, 95%CI: 1.11, 2.99). When the lowest quartile of cholesterol and the highest quartile for iron were compared to the highest quartile of cholesterol and the lowest quartile of iron, no association was seen in women, but for men PD risk was increased (OR=2.70, 95%CI: 1.26, 5.76). Saturated fat intake below the median in combination with iron intake above the median also increased the PD risk (OR=1.50, 95%CI: 1.07, 2.11) in both genders combined.

CONCLUSIONS

A low intake of cholesterol, particularly in the presence of high iron, may be associated with an increased risk for PD.

Authors+Show Affiliations

Department of Environmental and Occupational Health Sciences, University of Washington, Seattle, WA 98195-7234, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

18424169

Citation

Powers, Karen M., et al. "Dietary Fats, Cholesterol and Iron as Risk Factors for Parkinson's Disease." Parkinsonism & Related Disorders, vol. 15, no. 1, 2009, pp. 47-52.
Powers KM, Smith-Weller T, Franklin GM, et al. Dietary fats, cholesterol and iron as risk factors for Parkinson's disease. Parkinsonism Relat Disord. 2009;15(1):47-52.
Powers, K. M., Smith-Weller, T., Franklin, G. M., Longstreth, W. T., Swanson, P. D., & Checkoway, H. (2009). Dietary fats, cholesterol and iron as risk factors for Parkinson's disease. Parkinsonism & Related Disorders, 15(1), 47-52. https://doi.org/10.1016/j.parkreldis.2008.03.002
Powers KM, et al. Dietary Fats, Cholesterol and Iron as Risk Factors for Parkinson's Disease. Parkinsonism Relat Disord. 2009;15(1):47-52. PubMed PMID: 18424169.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Dietary fats, cholesterol and iron as risk factors for Parkinson's disease. AU - Powers,Karen M, AU - Smith-Weller,Terri, AU - Franklin,Gary M, AU - Longstreth,W T,Jr AU - Swanson,Phillip D, AU - Checkoway,Harvey, Y1 - 2008/04/18/ PY - 2007/11/19/received PY - 2008/01/31/revised PY - 2008/03/03/accepted PY - 2008/4/22/pubmed PY - 2009/3/27/medline PY - 2008/4/22/entrez SP - 47 EP - 52 JF - Parkinsonism & related disorders JO - Parkinsonism Relat Disord VL - 15 IS - 1 N2 - BACKGROUND: Epidemiologic findings suggest that dietary components may contribute to the etiology of Parkinson's disease (PD). This population-based case-control study evaluated PD risk and dietary intake of fats, cholesterol and iron. METHODS: Newly diagnosed case (n=420) and age/gender/ethnicity-matched unrelated controls (n=560) were identified between 1992 and 2006 from the Group Health Cooperative health maintenance organization in western Washington State, and the University of Washington Neurology Clinic. In-person interviews elicited data on food frequency habits during most of adult life. Nutritional intakes were calculated and analyzed, with adjustments made for total energy intake (the 'nutrition density' technique). RESULTS: Cholesterol intake in the highest quartile compared with the lowest quartile was associated with a decreased risk of PD in men (odds ratio (OR)=0.53, 95%CI: 0.33, 0.86). The highest versus the lowest quartile of dietary iron increased PD risk in men (OR=1.82, 95%CI: 1.11, 2.99). When the lowest quartile of cholesterol and the highest quartile for iron were compared to the highest quartile of cholesterol and the lowest quartile of iron, no association was seen in women, but for men PD risk was increased (OR=2.70, 95%CI: 1.26, 5.76). Saturated fat intake below the median in combination with iron intake above the median also increased the PD risk (OR=1.50, 95%CI: 1.07, 2.11) in both genders combined. CONCLUSIONS: A low intake of cholesterol, particularly in the presence of high iron, may be associated with an increased risk for PD. SN - 1353-8020 UR - https://www.unboundmedicine.com/medline/citation/18424169/Dietary_fats_cholesterol_and_iron_as_risk_factors_for_Parkinson's_disease_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1353-8020(08)00097-7 DB - PRIME DP - Unbound Medicine ER -