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Gastro-oesophageal reflux symptoms, oesophagitis and Barrett's oesophagus in the general population: the Loiano-Monghidoro study.
Gut 2008; 57(10):1354-9Gut

Abstract

OBJECTIVE

Existing endoscopy-based data on gastro-oesophageal reflux disease (GORD) in the general population are scarce. This study aimed to evaluate typical symptoms and complications of GORD, and their associated risk factors, in a representative sample of the Italian population.

METHODS

1533 adults from two Italian villages were approached to undergo symptom assessment using a validated questionnaire and upper gastrointestinal endoscopy. Data were obtained from 1033 individuals (67.4% response rate).

RESULTS

The prevalence of reflux symptoms was 44.3%; 23.7% of the population experienced such symptoms on at least 2 days per week (frequent symptoms). The prevalence rates of oesophagitis and Barrett's oesophagus in the population were 11.8% and 1.3%, respectively. Both frequent (relative risk (RR) 2.6; 95% confidence interval (CI) 1.7 to 3.9) and infrequent (RR 1.9; 95% CI 1.2 to 3.0) reflux symptoms were associated with the presence of oesophagitis. No reflux symptoms were reported by 32.8% of individuals with oesophagitis and 46.2% of those with Barrett's oesophagus. Hiatus hernia was associated with frequent reflux symptoms and oesophagitis, and was present in 76.9% of those with Barrett's oesophagus. We found no association between body mass index and reflux symptoms or oesophagitis.

CONCLUSIONS

GORD is common in Italy, but the prevalence of Barrett's oesophagus in the community is lower than has been reported in selected populations. Both frequent and infrequent reflux symptoms are associated with an increased risk of oesophagitis. Individuals with oesophagitis and Barrett's oesophagus often have no reflux symptoms.

Authors+Show Affiliations

Department of Internal Medicine and Gastroenterology, Bologna University, Policlinico Sant'Orsola, Via Massarenti n. 9, 40138 Bologna, Italy.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Evaluation Studies
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18424568

Citation

Zagari, R M., et al. "Gastro-oesophageal Reflux Symptoms, Oesophagitis and Barrett's Oesophagus in the General Population: the Loiano-Monghidoro Study." Gut, vol. 57, no. 10, 2008, pp. 1354-9.
Zagari RM, Fuccio L, Wallander MA, et al. Gastro-oesophageal reflux symptoms, oesophagitis and Barrett's oesophagus in the general population: the Loiano-Monghidoro study. Gut. 2008;57(10):1354-9.
Zagari, R. M., Fuccio, L., Wallander, M. A., Johansson, S., Fiocca, R., Casanova, S., ... Bazzoli, F. (2008). Gastro-oesophageal reflux symptoms, oesophagitis and Barrett's oesophagus in the general population: the Loiano-Monghidoro study. Gut, 57(10), pp. 1354-9. doi:10.1136/gut.2007.145177.
Zagari RM, et al. Gastro-oesophageal Reflux Symptoms, Oesophagitis and Barrett's Oesophagus in the General Population: the Loiano-Monghidoro Study. Gut. 2008;57(10):1354-9. PubMed PMID: 18424568.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Gastro-oesophageal reflux symptoms, oesophagitis and Barrett's oesophagus in the general population: the Loiano-Monghidoro study. AU - Zagari,R M, AU - Fuccio,L, AU - Wallander,M-A, AU - Johansson,S, AU - Fiocca,R, AU - Casanova,S, AU - Farahmand,B Y, AU - Winchester,C C, AU - Roda,E, AU - Bazzoli,F, Y1 - 2008/04/18/ PY - 2008/4/22/pubmed PY - 2008/10/17/medline PY - 2008/4/22/entrez SP - 1354 EP - 9 JF - Gut JO - Gut VL - 57 IS - 10 N2 - OBJECTIVE: Existing endoscopy-based data on gastro-oesophageal reflux disease (GORD) in the general population are scarce. This study aimed to evaluate typical symptoms and complications of GORD, and their associated risk factors, in a representative sample of the Italian population. METHODS: 1533 adults from two Italian villages were approached to undergo symptom assessment using a validated questionnaire and upper gastrointestinal endoscopy. Data were obtained from 1033 individuals (67.4% response rate). RESULTS: The prevalence of reflux symptoms was 44.3%; 23.7% of the population experienced such symptoms on at least 2 days per week (frequent symptoms). The prevalence rates of oesophagitis and Barrett's oesophagus in the population were 11.8% and 1.3%, respectively. Both frequent (relative risk (RR) 2.6; 95% confidence interval (CI) 1.7 to 3.9) and infrequent (RR 1.9; 95% CI 1.2 to 3.0) reflux symptoms were associated with the presence of oesophagitis. No reflux symptoms were reported by 32.8% of individuals with oesophagitis and 46.2% of those with Barrett's oesophagus. Hiatus hernia was associated with frequent reflux symptoms and oesophagitis, and was present in 76.9% of those with Barrett's oesophagus. We found no association between body mass index and reflux symptoms or oesophagitis. CONCLUSIONS: GORD is common in Italy, but the prevalence of Barrett's oesophagus in the community is lower than has been reported in selected populations. Both frequent and infrequent reflux symptoms are associated with an increased risk of oesophagitis. Individuals with oesophagitis and Barrett's oesophagus often have no reflux symptoms. SN - 1468-3288 UR - https://www.unboundmedicine.com/medline/citation/18424568/Gastro_oesophageal_reflux_symptoms_oesophagitis_and_Barrett's_oesophagus_in_the_general_population:_the_Loiano_Monghidoro_study_ L2 - http://gut.bmj.com/cgi/pmidlookup?view=long&pmid=18424568 DB - PRIME DP - Unbound Medicine ER -