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Dietary phytoestrogens are not associated with risk of overall breast cancer but diets rich in coumestrol are inversely associated with risk of estrogen receptor and progesterone receptor negative breast tumors in Swedish women.

Abstract

Results from epidemiological and experimental studies indicate that phytoestrogens may protect against breast cancer. Because one of the biological effects of phytoestrogens is probably estrogenic, it's possible that the preventive effect on breast cancer differs by estrogen receptor (ER) or progesterone receptor (PR) status of the tumor. We evaluated the associations between dietary phytoestrogen (isoflavonoids, lignans, and coumestrol) intake and risk of breast cancer and whether the ER/PR statuses of the tumor influence this relationship. In 1991-2 a prospective population-based cohort study among Swedish pre- and postmenopausal women was performed, making questionnaire data available for 45,448 women. A total of 1014 invasive breast cancers were diagnosed until December 2004. Cox proportional hazards models were performed to estimate multivariate risk ratios, 95% CI for associations with risk of breast cancer. Intakes of lignan, isoflavonoid, or coumestrol were not associated with breast cancer risk overall or before or after 50 y of age. The effects of lignans or isoflavonoids were independent of receptor status. However, intake of coumestrol was associated with decreased risk of receptor negative tumors (ER-PR-) but not positive tumors. The risk of ER-PR- tumors was significantly lower (50%) in women with intermediate coumestrol intake compared with those who did not consume any. In conclusion, we found no association between intake of isoflavonoids or lignans and breast cancer risk. Our results of a decreased risk of ER-PR- tumors in women with intermediate intake of coumestrol could be due to chance because of the low intake. The results should be confirmed in other studies.

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  • Authors+Show Affiliations

    ,

    Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, SE-171 77 Stockholm, Sweden. maria.hedelin@ki.se

    , , , ,

    Source

    The Journal of nutrition 138:5 2008 May pg 938-45

    MeSH

    Adult
    Breast Neoplasms
    Cohort Studies
    Coumestrol
    Diet
    Dietary Fiber
    Female
    Flavonoids
    Humans
    Lignans
    Middle Aged
    Phytoestrogens
    Prospective Studies
    Receptors, Estrogen
    Receptors, Progesterone
    Risk Factors
    Surveys and Questionnaires
    Sweden

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    18424605

    Citation

    Hedelin, Maria, et al. "Dietary Phytoestrogens Are Not Associated With Risk of Overall Breast Cancer but Diets Rich in Coumestrol Are Inversely Associated With Risk of Estrogen Receptor and Progesterone Receptor Negative Breast Tumors in Swedish Women." The Journal of Nutrition, vol. 138, no. 5, 2008, pp. 938-45.
    Hedelin M, Löf M, Olsson M, et al. Dietary phytoestrogens are not associated with risk of overall breast cancer but diets rich in coumestrol are inversely associated with risk of estrogen receptor and progesterone receptor negative breast tumors in Swedish women. J Nutr. 2008;138(5):938-45.
    Hedelin, M., Löf, M., Olsson, M., Adlercreutz, H., Sandin, S., & Weiderpass, E. (2008). Dietary phytoestrogens are not associated with risk of overall breast cancer but diets rich in coumestrol are inversely associated with risk of estrogen receptor and progesterone receptor negative breast tumors in Swedish women. The Journal of Nutrition, 138(5), pp. 938-45.
    Hedelin M, et al. Dietary Phytoestrogens Are Not Associated With Risk of Overall Breast Cancer but Diets Rich in Coumestrol Are Inversely Associated With Risk of Estrogen Receptor and Progesterone Receptor Negative Breast Tumors in Swedish Women. J Nutr. 2008;138(5):938-45. PubMed PMID: 18424605.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Dietary phytoestrogens are not associated with risk of overall breast cancer but diets rich in coumestrol are inversely associated with risk of estrogen receptor and progesterone receptor negative breast tumors in Swedish women. AU - Hedelin,Maria, AU - Löf,Marie, AU - Olsson,Marita, AU - Adlercreutz,Herman, AU - Sandin,Sven, AU - Weiderpass,Elisabete, PY - 2008/4/22/pubmed PY - 2008/5/2/medline PY - 2008/4/22/entrez SP - 938 EP - 45 JF - The Journal of nutrition JO - J. Nutr. VL - 138 IS - 5 N2 - Results from epidemiological and experimental studies indicate that phytoestrogens may protect against breast cancer. Because one of the biological effects of phytoestrogens is probably estrogenic, it's possible that the preventive effect on breast cancer differs by estrogen receptor (ER) or progesterone receptor (PR) status of the tumor. We evaluated the associations between dietary phytoestrogen (isoflavonoids, lignans, and coumestrol) intake and risk of breast cancer and whether the ER/PR statuses of the tumor influence this relationship. In 1991-2 a prospective population-based cohort study among Swedish pre- and postmenopausal women was performed, making questionnaire data available for 45,448 women. A total of 1014 invasive breast cancers were diagnosed until December 2004. Cox proportional hazards models were performed to estimate multivariate risk ratios, 95% CI for associations with risk of breast cancer. Intakes of lignan, isoflavonoid, or coumestrol were not associated with breast cancer risk overall or before or after 50 y of age. The effects of lignans or isoflavonoids were independent of receptor status. However, intake of coumestrol was associated with decreased risk of receptor negative tumors (ER-PR-) but not positive tumors. The risk of ER-PR- tumors was significantly lower (50%) in women with intermediate coumestrol intake compared with those who did not consume any. In conclusion, we found no association between intake of isoflavonoids or lignans and breast cancer risk. Our results of a decreased risk of ER-PR- tumors in women with intermediate intake of coumestrol could be due to chance because of the low intake. The results should be confirmed in other studies. SN - 1541-6100 UR - https://www.unboundmedicine.com/medline/citation/18424605/Dietary_phytoestrogens_are_not_associated_with_risk_of_overall_breast_cancer_but_diets_rich_in_coumestrol_are_inversely_associated_with_risk_of_estrogen_receptor_and_progesterone_receptor_negative_breast_tumors_in_Swedish_women_ L2 - https://academic.oup.com/jn/article-lookup/doi/10.1093/jn/138.5.938 DB - PRIME DP - Unbound Medicine ER -