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Cardiothoracic ratio, malnutrition, inflammation, and two-year mortality in non-diabetic patients on maintenance hemodialysis.
Kidney Blood Press Res. 2008; 31(3):143-51.KB

Abstract

BACKGROUND/AIMS

Cardiothoracic ratio (CTR) is associated with left ventricular mass, left ventricular systolic dysfunction and mortality in patients with hypertension or chronic cardiovascular disease. The clinical significance of CTR in non-diabetic maintenance hemodialysis (MHD) patients remains unclear.

METHODS

468 non-diabetic MHD patients were enrolled. Geographic, hematological, biochemical and dialysis-related data were obtained. The patients were analyzed for nutritional and inflammatory markers as well as CTR. All patients were followed up for 2 years to investigate the risks for mortality.

RESULTS

Chi-square analysis showed that the incidence of malnutrition and inflammation was significantly higher in patients with CTR >60% than in patients with CTR <or=60%. CTR positively correlated with high-sensitivity C-reactive protein (hsCRP) levels but negatively correlated with albumin levels. 29 patients (6.2%) had expired by the end of the study. Cox multivariate analysis revealed that CTR significantly predicts both all-cause and cardiovascular-cause 2-year mortality in non-diabetic MHD patients.

CONCLUSION

CTR is an indicator of inflammation and nutritional status in non-diabetic MHD patients and can predict 2-year mortality in these patients. The analytical results of this study support continued efforts to reduce CTR and treat underlying causes in patients with CTR >50%.

Authors+Show Affiliations

Department of Nephrology, Chang Gung Memorial Hospital, Chang Gung University, School of Medicine, Taoyuan, Taiwan, ROC.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Evaluation Study
Journal Article
Multicenter Study

Language

eng

PubMed ID

18424899

Citation

Chen, Kuan-Hsing, et al. "Cardiothoracic Ratio, Malnutrition, Inflammation, and Two-year Mortality in Non-diabetic Patients On Maintenance Hemodialysis." Kidney & Blood Pressure Research, vol. 31, no. 3, 2008, pp. 143-51.
Chen KH, Lin-Tan DT, Huang WH, et al. Cardiothoracic ratio, malnutrition, inflammation, and two-year mortality in non-diabetic patients on maintenance hemodialysis. Kidney Blood Press Res. 2008;31(3):143-51.
Chen, K. H., Lin-Tan, D. T., Huang, W. H., Hung, C. C., Chang, C. T., Huang, J. Y., & Lin, J. L. (2008). Cardiothoracic ratio, malnutrition, inflammation, and two-year mortality in non-diabetic patients on maintenance hemodialysis. Kidney & Blood Pressure Research, 31(3), 143-51. https://doi.org/10.1159/000127388
Chen KH, et al. Cardiothoracic Ratio, Malnutrition, Inflammation, and Two-year Mortality in Non-diabetic Patients On Maintenance Hemodialysis. Kidney Blood Press Res. 2008;31(3):143-51. PubMed PMID: 18424899.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Cardiothoracic ratio, malnutrition, inflammation, and two-year mortality in non-diabetic patients on maintenance hemodialysis. AU - Chen,Kuan-Hsing, AU - Lin-Tan,Dan-Tzu, AU - Huang,Wen-Hung, AU - Hung,Cheng-Chieh, AU - Chang,Chiz-Tzung, AU - Huang,Jeng-Yi, AU - Lin,Ja-Liang, Y1 - 2008/04/21/ PY - 2007/10/23/received PY - 2008/02/11/accepted PY - 2008/4/22/pubmed PY - 2008/8/8/medline PY - 2008/4/22/entrez SP - 143 EP - 51 JF - Kidney & blood pressure research JO - Kidney Blood Press Res VL - 31 IS - 3 N2 - BACKGROUND/AIMS: Cardiothoracic ratio (CTR) is associated with left ventricular mass, left ventricular systolic dysfunction and mortality in patients with hypertension or chronic cardiovascular disease. The clinical significance of CTR in non-diabetic maintenance hemodialysis (MHD) patients remains unclear. METHODS: 468 non-diabetic MHD patients were enrolled. Geographic, hematological, biochemical and dialysis-related data were obtained. The patients were analyzed for nutritional and inflammatory markers as well as CTR. All patients were followed up for 2 years to investigate the risks for mortality. RESULTS: Chi-square analysis showed that the incidence of malnutrition and inflammation was significantly higher in patients with CTR >60% than in patients with CTR <or=60%. CTR positively correlated with high-sensitivity C-reactive protein (hsCRP) levels but negatively correlated with albumin levels. 29 patients (6.2%) had expired by the end of the study. Cox multivariate analysis revealed that CTR significantly predicts both all-cause and cardiovascular-cause 2-year mortality in non-diabetic MHD patients. CONCLUSION: CTR is an indicator of inflammation and nutritional status in non-diabetic MHD patients and can predict 2-year mortality in these patients. The analytical results of this study support continued efforts to reduce CTR and treat underlying causes in patients with CTR >50%. SN - 1423-0143 UR - https://www.unboundmedicine.com/medline/citation/18424899/Cardiothoracic_ratio_malnutrition_inflammation_and_two_year_mortality_in_non_diabetic_patients_on_maintenance_hemodialysis_ L2 - https://www.karger.com?DOI=10.1159/000127388 DB - PRIME DP - Unbound Medicine ER -