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Prevalence of celiac disease among first degree relatives of Brazilian celiac patients.
Arq Gastroenterol 2008 Jan-Mar; 45(1):69-72AG

Abstract

BACKGROUND

Several studies have shown that celiac disease, an autoimmune disorder that occurs in genetically susceptible individuals, is highly prevalent among relatives of celiac patients.

AIM

To determine the prevalence of celiac disease in a group of first degree relatives of Brazilian celiac patients.

METHODS

First degree relatives of celiac patients attending the Brasilia University Hospital Pediatric Gastroenterology Outpatient Clinic or the Celiac Disease Investigation Center, Brasília, DF, Brazil, between March 2001 and November 2004 were invited to undergo serological screening for celiac disease applying the IgA anti-endomysium antibody test (IgA-EMA). All positive IgA-EMA sera underwent a second screening using the IgA anti-tissue transglutaminase antibodies test. Duodenal or small intestinal biopsies were performed in all subjects positive to serological testing. Biopsy samples were classified as type (O) normal, (I) infiltrative, (II) infiltrative hyperplastic, (III) flat destructive, and (IV) atrophic hypoplastic. The final diagnosis was ascertained in subjects showing positive serological tests and a grade I to III small intestinal lesion.

RESULTS

Nine new cases of celiac disease were found among the 188 first degree relatives tested (4.8%).

CONCLUSION

The present study confirms the high prevalence of celiac disease among first degree celiac patients relatives and reinforces the need of extensive diagnostic screening in this specific group.

Authors+Show Affiliations

Graduate Program in Health Sciences, University of Brasília School of Health Sciences, Brazil.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

18425232

Citation

Almeida, Patrícia Lopes de, et al. "Prevalence of Celiac Disease Among First Degree Relatives of Brazilian Celiac Patients." Arquivos De Gastroenterologia, vol. 45, no. 1, 2008, pp. 69-72.
Almeida PL, Gandolfi L, Modelli IC, et al. Prevalence of celiac disease among first degree relatives of Brazilian celiac patients. Arq Gastroenterol. 2008;45(1):69-72.
Almeida, P. L., Gandolfi, L., Modelli, I. C., Martins, R. d. e. . C., Almeida, R. C., & Pratesi, R. (2008). Prevalence of celiac disease among first degree relatives of Brazilian celiac patients. Arquivos De Gastroenterologia, 45(1), pp. 69-72.
Almeida PL, et al. Prevalence of Celiac Disease Among First Degree Relatives of Brazilian Celiac Patients. Arq Gastroenterol. 2008;45(1):69-72. PubMed PMID: 18425232.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Prevalence of celiac disease among first degree relatives of Brazilian celiac patients. AU - Almeida,Patrícia Lopes de, AU - Gandolfi,Lenora, AU - Modelli,Inês Cristina, AU - Martins,Rita de Cássia, AU - Almeida,Rodrigo Coutinho de, AU - Pratesi,Riccardo, PY - 2007/03/26/received PY - 2007/09/10/accepted PY - 2008/4/22/pubmed PY - 2008/12/30/medline PY - 2008/4/22/entrez SP - 69 EP - 72 JF - Arquivos de gastroenterologia JO - Arq Gastroenterol VL - 45 IS - 1 N2 - BACKGROUND: Several studies have shown that celiac disease, an autoimmune disorder that occurs in genetically susceptible individuals, is highly prevalent among relatives of celiac patients. AIM: To determine the prevalence of celiac disease in a group of first degree relatives of Brazilian celiac patients. METHODS: First degree relatives of celiac patients attending the Brasilia University Hospital Pediatric Gastroenterology Outpatient Clinic or the Celiac Disease Investigation Center, Brasília, DF, Brazil, between March 2001 and November 2004 were invited to undergo serological screening for celiac disease applying the IgA anti-endomysium antibody test (IgA-EMA). All positive IgA-EMA sera underwent a second screening using the IgA anti-tissue transglutaminase antibodies test. Duodenal or small intestinal biopsies were performed in all subjects positive to serological testing. Biopsy samples were classified as type (O) normal, (I) infiltrative, (II) infiltrative hyperplastic, (III) flat destructive, and (IV) atrophic hypoplastic. The final diagnosis was ascertained in subjects showing positive serological tests and a grade I to III small intestinal lesion. RESULTS: Nine new cases of celiac disease were found among the 188 first degree relatives tested (4.8%). CONCLUSION: The present study confirms the high prevalence of celiac disease among first degree celiac patients relatives and reinforces the need of extensive diagnostic screening in this specific group. SN - 0004-2803 UR - https://www.unboundmedicine.com/medline/citation/18425232/Prevalence_of_celiac_disease_among_first_degree_relatives_of_Brazilian_celiac_patients_ L2 - http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-28032008000100013&lng=en&nrm=iso&tlng=en DB - PRIME DP - Unbound Medicine ER -