Tags

Type your tag names separated by a space and hit enter

Effect of Coenzyme Q(10), Riboflavin and Niacin on Tamoxifen treated postmenopausal breast cancer women with special reference to blood chemistry profiles.
Breast Cancer Res Treat. 2009 Mar; 114(2):377-84.BC

Abstract

BACKGROUND

Tamoxifen (TAM) a non-steroidal antiestrogen, is widely used in adjuvant therapy for all stages of breast carcinomas and in chemoprevention of high-risk group. TAM also has estrogenic activity on liver and endometrium causing severe oxidative stress with various biochemical derangements. Coenzyme Q(10), Riboflavin and Niacin (CoRN) are well-known potent antioxidants and protective agents against many diseases including cancer. In this context, this study was undertaken to find if co-administration of TAM along with CoRN could alleviate the sole TAM-induced biochemical derangements in postmenopausal women with breast cancer.

METHOD

The vitamin supplementation with TAM was given for a period of 90 days. Blood samples were collected at the base line, 45th and 90th day during the course of treatment. Various blood chemistry profiles were assessed in 78 untreated, sole TAM treated and combinatorial treated group along with 46 age- and sex-matched controls.

RESULTS

A statistically significant alteration in various blood chemistry parameters, such as serum total bilirubin (S. BIL), serum glutamate oxaloacetate transaminase (SGOT), serum glutamate pyruvate transaminase (SGPT), gamma glutamyl transpeptidase (gamma-GT), uric acid (UA), lipoprotein lipase (LPL), lecithin: cholesterol acyl transferases (LCAT), potassium, calcium and Na(+), K(+)-ATPase in sole TAM-treated group, was favorably reverted back to near normal levels on combinatorial therapy with CoRN.

CONCLUSION

TAM on co-administration with CoRN has a favorable impact on various blood chemistry profiles. However, large scale randomized studies over a longer time span are required to ascertain the safety and efficacy of co-administrating antioxidants with conventional chemotherapy.

Authors+Show Affiliations

Department of Medical Biochemistry, Dr ALMP-GIBMS, University of Madras, Taramani Campus, Chennai, Tamil Nadu, India.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

18427979

Citation

Yuvaraj, Srinivasan, et al. "Effect of Coenzyme Q(10), Riboflavin and Niacin On Tamoxifen Treated Postmenopausal Breast Cancer Women With Special Reference to Blood Chemistry Profiles." Breast Cancer Research and Treatment, vol. 114, no. 2, 2009, pp. 377-84.
Yuvaraj S, Premkumar VG, Shanthi P, et al. Effect of Coenzyme Q(10), Riboflavin and Niacin on Tamoxifen treated postmenopausal breast cancer women with special reference to blood chemistry profiles. Breast Cancer Res Treat. 2009;114(2):377-84.
Yuvaraj, S., Premkumar, V. G., Shanthi, P., Vijayasarathy, K., Gangadaran, S. G., & Sachdanandam, P. (2009). Effect of Coenzyme Q(10), Riboflavin and Niacin on Tamoxifen treated postmenopausal breast cancer women with special reference to blood chemistry profiles. Breast Cancer Research and Treatment, 114(2), 377-84. https://doi.org/10.1007/s10549-008-0012-7
Yuvaraj S, et al. Effect of Coenzyme Q(10), Riboflavin and Niacin On Tamoxifen Treated Postmenopausal Breast Cancer Women With Special Reference to Blood Chemistry Profiles. Breast Cancer Res Treat. 2009;114(2):377-84. PubMed PMID: 18427979.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of Coenzyme Q(10), Riboflavin and Niacin on Tamoxifen treated postmenopausal breast cancer women with special reference to blood chemistry profiles. AU - Yuvaraj,Srinivasan, AU - Premkumar,Vummidi Gridhar, AU - Shanthi,Palanivel, AU - Vijayasarathy,Kothandaraman, AU - Gangadaran,Sitthu Govindaswamy Dinakaran, AU - Sachdanandam,Panchanatham, Y1 - 2008/04/22/ PY - 2008/04/03/received PY - 2008/04/04/accepted PY - 2008/4/23/pubmed PY - 2009/4/8/medline PY - 2008/4/23/entrez SP - 377 EP - 84 JF - Breast cancer research and treatment JO - Breast Cancer Res. Treat. VL - 114 IS - 2 N2 - BACKGROUND: Tamoxifen (TAM) a non-steroidal antiestrogen, is widely used in adjuvant therapy for all stages of breast carcinomas and in chemoprevention of high-risk group. TAM also has estrogenic activity on liver and endometrium causing severe oxidative stress with various biochemical derangements. Coenzyme Q(10), Riboflavin and Niacin (CoRN) are well-known potent antioxidants and protective agents against many diseases including cancer. In this context, this study was undertaken to find if co-administration of TAM along with CoRN could alleviate the sole TAM-induced biochemical derangements in postmenopausal women with breast cancer. METHOD: The vitamin supplementation with TAM was given for a period of 90 days. Blood samples were collected at the base line, 45th and 90th day during the course of treatment. Various blood chemistry profiles were assessed in 78 untreated, sole TAM treated and combinatorial treated group along with 46 age- and sex-matched controls. RESULTS: A statistically significant alteration in various blood chemistry parameters, such as serum total bilirubin (S. BIL), serum glutamate oxaloacetate transaminase (SGOT), serum glutamate pyruvate transaminase (SGPT), gamma glutamyl transpeptidase (gamma-GT), uric acid (UA), lipoprotein lipase (LPL), lecithin: cholesterol acyl transferases (LCAT), potassium, calcium and Na(+), K(+)-ATPase in sole TAM-treated group, was favorably reverted back to near normal levels on combinatorial therapy with CoRN. CONCLUSION: TAM on co-administration with CoRN has a favorable impact on various blood chemistry profiles. However, large scale randomized studies over a longer time span are required to ascertain the safety and efficacy of co-administrating antioxidants with conventional chemotherapy. SN - 1573-7217 UR - https://www.unboundmedicine.com/medline/citation/18427979/Effect_of_Coenzyme_Q_10__Riboflavin_and_Niacin_on_Tamoxifen_treated_postmenopausal_breast_cancer_women_with_special_reference_to_blood_chemistry_profiles_ L2 - https://doi.org/10.1007/s10549-008-0012-7 DB - PRIME DP - Unbound Medicine ER -