Tags

Type your tag names separated by a space and hit enter

Efficacy of Hylan G-F 20 and Sodium Hyaluronate in the treatment of osteoarthritis of the knee -- a prospective randomized clinical trial.
Knee. 2008 Aug; 15(4):318-24.KNEE

Abstract

In this independent prospective randomized trial, we compared the clinical effectiveness, functional outcome and patient satisfaction following intra articular injection with two viscosupplementation agents - Hylan G-F-20 (n=199) and Sodium Hyaluronate (n=193) in patients with osteoarthritis (OA) of the knee. All patients were prospectively reviewed by blinded independent assessors at pre injection, 6 weeks, 3, 6, 12 months. Knee pain and patient satisfaction were measured on a visual analogue scale. Functional outcome was assessed using WOMAC, Oxford knee score and EuroQol EQ-5D scores. Knee pain on VAS improved from 6.7 to 3.2 by 6 weeks (p=0.02) and was sustained until 12 months (3.7, p=0.04) with Hylan G-F 20. In the Sodium Hyaluronate group, pain improved from 6.6 to 5.7 at 6 weeks (p>0.05) and to 4.1 at 3 months (p=0.04) but was sustained only until 6 months (5.9, p>0.05). Improvement in the WOMAC pain subscale was significantly superior in the Hylan G-F 20 group at 3 months (p=0.02), 6 months (p=0.01) and 12 months (p=0.007). There was no significant difference in the EQ-5D scores at 6 weeks and 3 months between the two groups. The numbers of treatment related adverse events were higher (39 vs. 30) in the Hylan G-F 20 group. One patient in the Hylan G-F 20 group who had a serious adverse event was also included in the final analysis. Although both treatments offered significant pain reduction, it was achieved earlier and sustained for a longer period with Hylan G-F 20. From this study, it appeared that the clinical effectiveness and general patient satisfaction are better amongst patients who received Hylan G-F 20.

Authors+Show Affiliations

Department of Trauma and Orthopaedics, Hull Royal Infirmary, Hull, HU2 3JZ, United Kingdom. raghu1177@yahoo.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

18430574

Citation

Raman, R, et al. "Efficacy of Hylan G-F 20 and Sodium Hyaluronate in the Treatment of Osteoarthritis of the Knee -- a Prospective Randomized Clinical Trial." The Knee, vol. 15, no. 4, 2008, pp. 318-24.
Raman R, Dutta A, Day N, et al. Efficacy of Hylan G-F 20 and Sodium Hyaluronate in the treatment of osteoarthritis of the knee -- a prospective randomized clinical trial. Knee. 2008;15(4):318-24.
Raman, R., Dutta, A., Day, N., Sharma, H. K., Shaw, C. J., & Johnson, G. V. (2008). Efficacy of Hylan G-F 20 and Sodium Hyaluronate in the treatment of osteoarthritis of the knee -- a prospective randomized clinical trial. The Knee, 15(4), 318-24. https://doi.org/10.1016/j.knee.2008.02.012
Raman R, et al. Efficacy of Hylan G-F 20 and Sodium Hyaluronate in the Treatment of Osteoarthritis of the Knee -- a Prospective Randomized Clinical Trial. Knee. 2008;15(4):318-24. PubMed PMID: 18430574.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Efficacy of Hylan G-F 20 and Sodium Hyaluronate in the treatment of osteoarthritis of the knee -- a prospective randomized clinical trial. AU - Raman,R, AU - Dutta,A, AU - Day,N, AU - Sharma,H K, AU - Shaw,C J, AU - Johnson,G V, Y1 - 2008/04/21/ PY - 2008/01/26/received PY - 2008/02/24/revised PY - 2008/02/25/accepted PY - 2008/4/24/pubmed PY - 2008/12/17/medline PY - 2008/4/24/entrez SP - 318 EP - 24 JF - The Knee JO - Knee VL - 15 IS - 4 N2 - In this independent prospective randomized trial, we compared the clinical effectiveness, functional outcome and patient satisfaction following intra articular injection with two viscosupplementation agents - Hylan G-F-20 (n=199) and Sodium Hyaluronate (n=193) in patients with osteoarthritis (OA) of the knee. All patients were prospectively reviewed by blinded independent assessors at pre injection, 6 weeks, 3, 6, 12 months. Knee pain and patient satisfaction were measured on a visual analogue scale. Functional outcome was assessed using WOMAC, Oxford knee score and EuroQol EQ-5D scores. Knee pain on VAS improved from 6.7 to 3.2 by 6 weeks (p=0.02) and was sustained until 12 months (3.7, p=0.04) with Hylan G-F 20. In the Sodium Hyaluronate group, pain improved from 6.6 to 5.7 at 6 weeks (p>0.05) and to 4.1 at 3 months (p=0.04) but was sustained only until 6 months (5.9, p>0.05). Improvement in the WOMAC pain subscale was significantly superior in the Hylan G-F 20 group at 3 months (p=0.02), 6 months (p=0.01) and 12 months (p=0.007). There was no significant difference in the EQ-5D scores at 6 weeks and 3 months between the two groups. The numbers of treatment related adverse events were higher (39 vs. 30) in the Hylan G-F 20 group. One patient in the Hylan G-F 20 group who had a serious adverse event was also included in the final analysis. Although both treatments offered significant pain reduction, it was achieved earlier and sustained for a longer period with Hylan G-F 20. From this study, it appeared that the clinical effectiveness and general patient satisfaction are better amongst patients who received Hylan G-F 20. SN - 0968-0160 UR - https://www.unboundmedicine.com/medline/citation/18430574/Efficacy_of_Hylan_G_F_20_and_Sodium_Hyaluronate_in_the_treatment_of_osteoarthritis_of_the_knee____a_prospective_randomized_clinical_trial_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0968-0160(08)00043-4 DB - PRIME DP - Unbound Medicine ER -