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Transcriptional control of mitochondrial biogenesis: the central role of PGC-1alpha.
Cardiovasc Res. 2008 Jul 15; 79(2):208-17.CR

Abstract

Although the concept of energy starvation in the failing heart was proposed decades ago, still very little is known about the origin of energetic failure. Recent advances in molecular biology have started to elucidate the transcriptional events governing mitochondrial biogenesis. In particular, a great step was taken with the discovery that peroxisome proliferator-activated receptor gamma co-activator (PGC-1alpha) is the master regulator of mitochondrial biogenesis. The molecular mechanisms underlying the downregulation of PGC-1alpha and the consequent decrease in mitochondrial function in heart failure are, however, still poorly understood. Indeed, the main pathways involved in mitochondrial biogenesis are thought to be up- rather than down-regulated in pathological hypertrophy and heart failure. The current review summarizes recent advances in this field and is restricted to the heart when cardiac data are available.

Authors+Show Affiliations

Faculté de Pharmacie, INSERM U-769, F-92296 Châtenay-Malabry, France. renee.ventura@u-psud.frNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

18430751

Citation

Ventura-Clapier, Renée, et al. "Transcriptional Control of Mitochondrial Biogenesis: the Central Role of PGC-1alpha." Cardiovascular Research, vol. 79, no. 2, 2008, pp. 208-17.
Ventura-Clapier R, Garnier A, Veksler V. Transcriptional control of mitochondrial biogenesis: the central role of PGC-1alpha. Cardiovasc Res. 2008;79(2):208-17.
Ventura-Clapier, R., Garnier, A., & Veksler, V. (2008). Transcriptional control of mitochondrial biogenesis: the central role of PGC-1alpha. Cardiovascular Research, 79(2), 208-17. https://doi.org/10.1093/cvr/cvn098
Ventura-Clapier R, Garnier A, Veksler V. Transcriptional Control of Mitochondrial Biogenesis: the Central Role of PGC-1alpha. Cardiovasc Res. 2008 Jul 15;79(2):208-17. PubMed PMID: 18430751.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Transcriptional control of mitochondrial biogenesis: the central role of PGC-1alpha. AU - Ventura-Clapier,Renée, AU - Garnier,Anne, AU - Veksler,Vladimir, Y1 - 2008/04/22/ PY - 2008/4/24/pubmed PY - 2008/9/24/medline PY - 2008/4/24/entrez SP - 208 EP - 17 JF - Cardiovascular research JO - Cardiovasc. Res. VL - 79 IS - 2 N2 - Although the concept of energy starvation in the failing heart was proposed decades ago, still very little is known about the origin of energetic failure. Recent advances in molecular biology have started to elucidate the transcriptional events governing mitochondrial biogenesis. In particular, a great step was taken with the discovery that peroxisome proliferator-activated receptor gamma co-activator (PGC-1alpha) is the master regulator of mitochondrial biogenesis. The molecular mechanisms underlying the downregulation of PGC-1alpha and the consequent decrease in mitochondrial function in heart failure are, however, still poorly understood. Indeed, the main pathways involved in mitochondrial biogenesis are thought to be up- rather than down-regulated in pathological hypertrophy and heart failure. The current review summarizes recent advances in this field and is restricted to the heart when cardiac data are available. SN - 0008-6363 UR - https://www.unboundmedicine.com/medline/citation/18430751/Transcriptional_control_of_mitochondrial_biogenesis:_the_central_role_of_PGC_1alpha_ L2 - https://academic.oup.com/cardiovascres/article-lookup/doi/10.1093/cvr/cvn098 DB - PRIME DP - Unbound Medicine ER -